dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001456
Uniprot Accession O43155; FLRT2_HUMAN; A0AV84; B7ZLP3;
Genbank Protein ID NP_037363.1; XP_005267547.1; XP_011534913.1;
Genbank Nucleotide ID NM_013231.4; XM_005267490.2; XM_011536611.1;
Protein Name Leucine-rich repeat transmembrane protein FLRT2
Protein Synonyms/Alias Fibronectin-like domain-containing leucine-rich transmembrane protein 2;
Gene Name FLRT2
Gene Synonyms/Alias KIAA0405;UNQ232/PRO265;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
10LQTTKWPSHGAFFLKPhosphoSitePlus22135298
284KLERLDISNNQLRMLPhosphoSitePlus22135298
292NNQLRMLTQGVFDNLPhosphoSitePlus22135298
300QGVFDNLSNLKQLTAPhosphoSitePlus22135298
395IPNPSRSYTPPTPTTPhosphoSitePlus22135298
418WDGRERVTPPISERIPhosphoSitePlus22135298
422ERVTPPISERIQLSIPhosphoSitePlus22135298
593DDYCEAGTKKDNSILPhosphoSitePlus22135298
628DFRLQPIYTPNGGINPhosphoSitePlus22135298
636TPNGGINYTDCHIPNPhosphoSitePlus22135298
651NMRYCNSSVPDLEHCcurated23898821; 24961811
Sequence
(Fasta)		MGLQTTKWPS HGAFFLKSWL IISLGLYSQV SKLLACPSVC RCDRNFVYCN ERSLTSVPLG 60
IPEGVTVLYL HNNQINNAGF PAELHNVQSV HTVYLYGNQL DEFPMNLPKN VRVLHLQENN 120
IQTISRAALA QLLKLEELHL DDNSISTVGV EDGAFREAIS LKLLFLSKNH LSSVPVGLPV 180
DLQELRVDEN RIAVISDMAF QNLTSLERLI VDGNLLTNKG IAEGTFSHLT KLKEFSIVRN 240
SLSHPPPDLP GTHLIRLYLQ DNQINHIPLT AFSNLRKLER LDISNNQLRM LTQGVFDNLS 300
NLKQLTARNN PWFCDCSIKW VTEWLKYIPS SLNVRGFMCQ GPEQVRGMAV RELNMNLLSC 360
PTTTPGLPLF TPAPSTASPT TQPPTLSIPN PSRSYTPPTP TTSKLPTIPD WDGRERVTPP 420
ISERIQLSIH FVNDTSIQVS WLSLFTVMAY KLTWVKMGHS LVGGIVQERI VSGEKQHLSL 480
VNLEPRSTYR ICLVPLDAFN YRAVEDTICS EATTHASYLN NGSNTASSHE QTTSHSMGSP 540
FLLAGLIGGA VIFVLVVLLS VFCWHMHKKG RYTSQKWKYN RGRRKDDYCE AGTKKDNSIL 600
EMTETSFQIV SLNNDQLLKG DFRLQPIYTP NGGINYTDCH IPNNMRYCNS SVPDLEHCHT 660
661
Keyword

KW-0130--Cell adhesion
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0256--Endoplasmic reticulum
KW-0272--Extracellular matrix
KW-0325--Glycoprotein
KW-0433--Leucine-rich repeat
KW-0472--Membrane
KW-0492--Microsome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal
KW-0770--Synapse
KW-0771--Synaptosome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR000483--Cys-rich_flank_reg_C
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR001611--Leu-rich_rpt
IPR003591--Leu-rich_rpt_typical-subtyp
IPR000372--LRRNT
PROSITE

PS50853--FN3
Pfam

PF13855--LRR_8
PF01463--LRRCT
Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005789--C:endoplasmic reticulum membrane
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0005925--C:focal adhesion
GO:0005887--C:integral component of plasma membrane
GO:0043005--C:neuron projection
GO:0005578--C:proteinaceous extracellular matrix
GO:0045202--C:synapse
GO:0045499--F:chemorepellent activity
GO:0030674--F:protein binding, bridging
GO:0005057--F:receptor signaling protein activity
GO:0007411--P:axon guidance
GO:0071711--P:basement membrane organization
GO:0061343--P:cell adhesion involved in heart morphogenesis
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0003007--P:heart morphogenesis
GO:0035556--P:intracellular signal transduction
GO:0051965--P:positive regulation of synapse assembly
GO:2001222--P:regulation of neuron migration