dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001454
Uniprot Accession O43150; ASAP2_HUMAN; D6W4Y8;
Genbank Protein ID NP_001128663.1; NP_003878.1;
Genbank Nucleotide ID NM_001135191.1; NM_003887.2;
Protein Name Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
Protein Synonyms/Alias Development and differentiation-enhancing factor 2;Paxillin-associated protein with ARF GAP activity 3;PAG3;Pyk2 C-terminus-associated protein;PAP;
Gene Name ASAP2
Gene Synonyms/Alias DDEF2;KIAA0400;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration.
Phosphorylation Sites
 dbPAF PTMs: 25 (View all)
PositionPeptidesSourceReferences ( PMIDs )
201FQLQMCEYLLKVNEIPhosphoSitePlus22135298
249KPSIETLSTDLHTIKPHOSIDA21081558
250PSIETLSTDLHTIKQPHOSIDA21081558
254TLSTDLHTIKQAQDEPHOSIDA21081558
293QIRQSTAYSLHQPQGdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 25627689; 22817900
294IRQSTAYSLHQPQGNPhosphoSitePlus22135298
329VWQKRKCSVKNGFLTPhosphoSitePlus;curated22135298; 22817900
336SVKNGFLTISHGTANPhosphoSitePlus;curated22135298; 22817900
338KNGFLTISHGTANRPPhosphoSitePlus;curated22135298; 22817900
556SLCEAVKTRDIFGLLPhosphoSitePlus22135298
689NSHVHVEYEWRLLHEPhosphoSitePlus22135298
701LHEDLDESDDDMDEKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18088087; 18669648; 16381945; 23193290; 18707149;
722RREDRPISFYQLGSNPhosphoSitePlus22135298
724EDRPISFYQLGSNQLPhosphoSitePlus;curated22135298; 22817900
728ISFYQLGSNQLQSNAPhosphoSitePlus22135298
756KQRAFMPSILQNETYPhosphoPep 2.019060867
762PSILQNETYGALLSGPhosphoPep 2.019060867
763SILQNETYGALLSGSdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
770YGALLSGSPPPAQPAcurated25850435
809NTLWKTNSVSVDGGSPhosphoSitePlus22135298
Sequence
(Fasta)		MPDQISVSEF VAETHEDYKA PTASSFTTRT AQCRNTVAAI EEALDVDRMV LYKMKKSVKA 60
INSSGLAHVE NEEQYTQALE KFGGNCVCRD DPDLGSAFLK FSVFTKELTA LFKNLIQNMN 120
NIISFPLDSL LKGDLKGVKG DLKKPFDKAW KDYETKITKI EKEKKEHAKL HGMIRTEISG 180
AEIAEEMEKE RRFFQLQMCE YLLKVNEIKI KKGVDLLQNL IKYFHAQCNF FQDGLKAVES 240
LKPSIETLST DLHTIKQAQD EERRQLIQLR DILKSALQVE QKEDSQIRQS TAYSLHQPQG 300
NKEHGTERNG SLYKKSDGIR KVWQKRKCSV KNGFLTISHG TANRPPAKLN LLTCQVKTNP 360
EEKKCFDLIS HDRTYHFQAE DEQECQIWMS VLQNSKEEAL NNAFKGDDNT GENNIVQELT 420
KEIISEVQRM TGNDVCCDCG APDPTWLSTN LGILTCIECS GIHRELGVHY SRMQSLTLDV 480
LGTSELLLAK NIGNAGFNEI MECCLPAEDS VKPNPGSDMN ARKDYITAKY IERRYARKKH 540
ADNAAKLHSL CEAVKTRDIF GLLQAYADGV DLTEKIPLAN GHEPDETALH LAVRSVDRTS 600
LHIVDFLVQN SGNLDKQTGK GSTALHYCCL TDNAECLKLL LRGKASIEIA NESGETPLDI 660
AKRLKHEHCE ELLTQALSGR FNSHVHVEYE WRLLHEDLDE SDDDMDEKLQ PSPNRREDRP 720
ISFYQLGSNQ LQSNAVSLAR DAANLAKEKQ RAFMPSILQN ETYGALLSGS PPPAQPAAPS 780
TTSAPPLPPR NVGKVQTASS ANTLWKTNSV SVDGGSRQRS SSDPPAVHPP LPPLRVTSTN 840
PLTPTPPPPV AKTPSVMEAL SQPSKPAPPG ISQIRPPPLP PQPPSRLPQK KPAPGADKST 900
PLTNKGQPRG PVDLSATEAL GPLSNAMVLQ PPAPMPRKSQ ATKLKPKRVK ALYNCVADNP 960
DELTFSEGDV IIVDGEEDQE WWIGHIDGDP GRKGAFPVSF VHFIAD 1007
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0343--GTPase activation
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0862--Zinc
Interpro

IPR027267--AH/BAR-dom
IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001164--ArfGAP
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR001452--SH3_domain
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50115--ARFGAP
PS50003--PH_DOMAIN
PS50002--SH3
Pfam

PF12796--Ank_2
PF01412--ArfGap
PF00169--PH
PF14604--SH3_9
Gene Ontology

GO:0032580--C:Golgi cisterna membrane
GO:0005886--C:plasma membrane
GO:0008047--F:enzyme activator activity
GO:0005096--F:GTPase activator activity
GO:0046872--F:metal ion binding
GO:0043085--P:positive regulation of catalytic activity