dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001452
Uniprot Accession O43148; MCES_HUMAN; B0YJ90; D3DUJ5; O94996; Q9UIJ9;
Genbank Protein ID NP_001295192.1; NP_003790.1; XP_005258219.1;
Genbank Nucleotide ID NM_001308263.1; NM_003799.2; XM_005258162.1;
Protein Name mRNA cap guanine-N7 methyltransferase
Protein Synonyms/Alias RG7MT1;mRNA (guanine-N(7)-)-methyltransferase;mRNA cap methyltransferase;hCMT1;hMet;hcm1p;
Gene Name RNMT
Gene Synonyms/Alias KIAA0398;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.
Phosphorylation Sites
 dbPAF PTMs: 16
PositionPeptidesSourceReferences ( PMIDs )
10NSAKAEEYEKMSLEQPhosphoSitePlus22135298
21SLEQAKASVNSETEScurated25627689
44TASGTGLSEKTSVCRPhosphoSitePlus22135298
72DLVKESSSCGKDTPScurated25849741
77SSSCGKDTPSKKRKLPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 26074081; 25849741
79SCGKDTPSKKRKLDPcurated26074081
153SSTVAAHYNELQEVGPhosphoSitePlus22135298
181NFNNWMKSVLIGEFLPHOSIDA21081558
232CTDIADVSVKQCQQRdbPTM 3.0;HPRD 9;PHOSIDA;curated20068231; 16381945; 23193290; 18988627; 21081558; 22817900
313ERLSPGGYFIGTTPNcurated25262027
317PGGYFIGTTPNSFELcurated25262027
318GGYFIGTTPNSFELIcurated25262027
321FIGTTPNSFELIRRLcurated25262027
385LNEMAKKYNMKLVYKPhosphoSitePlus22135298
447AAKYMKNSQVRLPLGPhosphoSitePlus22135298
455QVRLPLGTLSKSEWEdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MANSAKAEEY EKMSLEQAKA SVNSETESSF NINENTTASG TGLSEKTSVC RQVDIARKRK 60
EFEDDLVKES SSCGKDTPSK KRKLDPEIVP EEKDCGDAEG NSKKRKRETE DVPKDKSSTG 120
DGTQNKRKIA LEDVPEKQKN LEEGHSSTVA AHYNELQEVG LEKRSQSRIF YLRNFNNWMK 180
SVLIGEFLEK VRQKKKRDIT VLDLGCGKGG DLLKWKKGRI NKLVCTDIAD VSVKQCQQRY 240
EDMKNRRDSE YIFSAEFITA DSSKELLIDK FRDPQMCFDI CSCQFVCHYS FESYEQADMM 300
LRNACERLSP GGYFIGTTPN SFELIRRLEA SETESFGNEI YTVKFQKKGD YPLFGCKYDF 360
NLEGVVDVPE FLVYFPLLNE MAKKYNMKLV YKKTFLEFYE EKIKNNENKM LLKRMQALEP 420
YPANESSKLV SEKVDDYEHA AKYMKNSQVR LPLGTLSKSE WEATSIYLVF AFEKQQ 477
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0506--mRNA capping
KW-0507--mRNA processing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
Interpro

IPR016899--mRNA_G-N7_MeTrfase
IPR004971--mRNA_G-N7_MeTrfase_dom
IPR029063--SAM-dependent_MTases
PROSITE

PS51562--RNA_CAP0_MT
Pfam

PF03291--Pox_MCEL
Gene Ontology

GO:0005845--C:mRNA cap binding complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043235--C:receptor complex
GO:0004482--F:mRNA (guanine-N7-)-methyltransferase activity
GO:0003723--F:RNA binding
GO:0006370--P:7-methylguanosine mRNA capping
GO:0010467--P:gene expression
GO:0036265--P:RNA (guanine-N7)-methylation
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0016032--P:viral process