dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0001404 |
| Uniprot Accession | O42939; UBA2_SCHPO; |
| Genbank Protein ID | NP_595945.1; |
| Genbank Nucleotide ID | NM_001021853.2; |
| Protein Name | Ubiquitin-activating enzyme E1-like |
| Protein Synonyms/Alias | Pmt3-activating enzyme subunit 2; |
| Gene Name | uba2 |
| Gene Synonyms/Alias | SPBC16H5.03c; |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID | 284812 |
| Functional Description (View all) |
The dimeric enzyme acts as a SUMO/pmt3 E1 ligase. It mediates ATP-dependent activation of pmt3 and formation of a thioester with a conserved cysteine residue on aos1 (By similarity). |
| Phosphorylation Sites |
dbPAF PTMs: 3 |
| Sequence (Fasta) | MPTLMQLSND MKPLTFVEAL RNFKSAKVLL VGAGGIGCEL LKNLLMSGVK EVHIIDLDTI 60 DLSNLNRQFL FRKKHVKQPK AIVAAKTASS FNPNVKLEAY HANIKEDRFN VAWFRQFDLV 120 FNALDNLDAR RHVNKQCLLA SVPLIESGTT GFLGQVQVII HGKTECYDCN PKEPPKTYPV 180 CTIRSTPSQP IHCVVWAKSY FFPQLFSNDQ ESDGIIDNVS ANEMERREIA ELARETTELN 240 ELRSSIGQSD NGFEKIFTKM FTKDIVRLRE VPDAWTYRSP PKELSYSELL ENAEKATSPW 300 LNEQNVWNVA ESFAVLRDSI RRLALRSKSS KDDLSFDKDD KDTLDFVAAA ANLRAHVFGI 360 QQLSEFDIKQ MAGNIIPAIA TTNAVIAGLC ITQAIKVLQG DLNDLKNIYL AKRPTRVLHC 420 EKTCKPNPYC PTCSFVLLQL GVNDKNMTLR VLVDDILKSR LHYSEEVSVL NDKLIYDPDF 480 DDNLDKTFDD LGINPAKNTI LTVLGDSAVE KDDDGEEATR VPLLIEVTFI DSNSTEGLPY 540 QILSNATSIP LKQQPPSNSP EDSQVLTDEI NEVNDFSSSE RIVINLDEYD IIVDSKTSSH 600 NKQLKRRPSN DTLTQEAKSK KQAKIHTM 629 |
| Keyword | KW-0067--ATP-binding |
| Interpro | IPR016040--NAD(P)-bd_dom |
| PROSITE | PS00865--UBIQUITIN_ACTIVAT_2 |
| Pfam | |
| Gene Ontology | GO:0005634--C:nucleus |