dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001403
Uniprot Accession O42938; PFKA_SCHPO; P78762;
Genbank Protein ID NP_595946.1;
Genbank Nucleotide ID NM_001021854.2;
Protein Name ATP-dependent 6-phosphofructokinase
Protein Synonyms/Alias
Gene Name pfk1
Gene Synonyms/Alias SPBC16H5.02;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)		 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. May also have a role in cell cycle regulation.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
43KVASFGTSDSDNARVdbPTM 3.0;UniProt18257517; 16381945; 23193290
45ASFGTSDSDNARVCNdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
85VPGELSLSPAAEDSEdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
160AHANLKKSEESGAASdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
163NLKKSEESGAASNLEdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
167SEESGAASNLESGLAdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
171GAASNLESGLATPVVdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
175NLESGLATPVVETLKdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
180LATPVVETLKKATTScurated22817900
600APAGGMNSATRAAVRdbPTM 3.0;UniProt18257517; 16381945; 23193290
602AGGMNSATRAAVRYCdbPTM 3.0;UniProt18257517; 16381945; 23193290
Sequence
(Fasta)		MSGETVHGIS CYSVVANTED TYNQTLDFYQ KLGFKKVASF GTSDSDNARV CNESLREDWM 60
HVAGNNSAES VTIKFRLVPG ELSLSPAAED SEWRGQKSSL VFYYPNLLDL LKQLSADAIK 120
YQAFPNEKKP DEVYVEDPLG NLIGFSDRYN PFAHANLKKS EESGAASNLE SGLATPVVET 180
LKKATTSDKP AGVKKKIAVM TSGGDSPGMN AVVRAVARIA IHRGCDAFAI YEGYEGLVQG 240
GDMIKQLQWG DVRGWLAEGG TLIGTARCMA FRERPGRLRA AKNLISAGID SIIVCGGDGS 300
LTGADIFRSD WPGLVKELED TKAITPEQAK LYRHLTIVGL VGSIDNDMSS TDVTIGAFSS 360
LHRICEAVDS ISSTAISHSR AFIVEVMGRH CGWLAVLAAL ATGADFVFIP ERPAEVGKWQ 420
DELCNSLSSV RKLGKRKSIV IVAEGAIDSE LNHISPEDIK NLLVERLHLD TRVTTLGHVQ 480
RGGIPCAYDR MLATLQGVDA VDAVLASTPD TPSPMIAING NKINRKPLME AVKLTHEVAD 540
AIEKKQFAHA MELRDPEFAD YLHTWEGTTF IEDESHFVPK DERMRVAIIH VGAPAGGMNS 600
ATRAAVRYCL NRGHTPLAID NGFSGFLRHD SIHELSWIDV DEWCIRGGSE IGTNRDTPDL 660
DMGFTAFKFQ QHKIDALIII GGFEAFTALS QLESARVNYP SFRIPMAIIP ATISNNVPGT 720
EFSLGCDTCL NAVMEYCDTI KQSASASRRR VFVCEVQGGR SGYIATVGGL ITGASAIYTP 780
EDGISLDMLR KDIDHLKATF ALEAGRNRAG QLILRNECAS KVYTTEVIGN IISEEAHKRF 840
SARTAVPGHV QQGGNPTPMD RARAARLAMR AIRFFETCRA NDLGNDPSSA VVIGIRGTGV 900
SFSSVADVEN NETEIEMRRP KNAWWRDMHN LVNILAGKTF AD 943
Keyword

KW-0021--Allosteric enzyme
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0324--Glycolysis
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR009161--6-Pfructokinase_euk
IPR022953--ATP_PFK
IPR029068--Glyas_Bleomycin-R_OHBP_Dase
IPR015912--Phosphofructokinase_CS
IPR000023--Phosphofructokinase_dom
PROSITE

PS00433--PHOSPHOFRUCTOKINASE
Pfam

PF00365--PFK
Gene Ontology

GO:0005945--C:6-phosphofructokinase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0003872--F:6-phosphofructokinase activity
GO:0005524--F:ATP binding
GO:0070095--F:fructose-6-phosphate binding
GO:0046872--F:metal ion binding
GO:0061621--P:canonical glycolysis
GO:0030388--P:fructose 1,6-bisphosphate metabolic process
GO:0006002--P:fructose 6-phosphate metabolic process