dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001400
Uniprot Accession O42931; PRS7_SCHPO;
Genbank Protein ID NP_596805.1;
Genbank Nucleotide ID NM_001023826.2;
Protein Name 26S protease regulatory subunit 7 homolog
Protein Synonyms/Alias
Gene Name rpt1
Gene Synonyms/Alias SPBC16C6.07c;
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
NCBI Taxa ID 284812
Functional Description
(View all)
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
90AADRQRMSEEQPLQVdbPTM 3.0;SysPTM 2.0;UniProt;curated18257517; 16381945; 23193290; 19366988; 22817900
Sequence
(Fasta)
MPPKEDWEKY QKPVDTEEEN DKNPPPLDEG DIELLKSYAT GPYARELAAI KEDTEAVLKR 60
INDTVGIKES DTGLAPISFW DVAADRQRMS EEQPLQVARC TKIIENEQSA EKNAYVINLK 120
QIAKFVVSLG ERVSPTDIEE GMRVGCDRNK YAIQLPLPPK IDPSVTMMQV EEKPDVTYGD 180
VGGCKEQIER LREVVELPLL SPERFVKLGI DPPKGIMLYG PPGTGKTLCA RAVANRTDAT 240
FIRVIGSELV QKYVGEGARM VRELFEMART KKACIIFFDE IDAIGGARFD DGAGGDNEVQ 300
RTMLELITQL DGFDPRGNIK VLFATNRPNT LDEALMRPGR IDRKVEFGLP DLEGRAHILR 360
IHAKSMAIDK DIRWELIARL CPSQTGAELR SVCTEAGMFA IRARRRVATE KDFLDAVQKV 420
VKGNQKFSST ADYMNMSS 439
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome

Interpro

IPR005937--26S_Psome_P45
IPR003593--AAA+_ATPase
IPR003959--ATPase_AAA_core
IPR003960--ATPase_AAA_CS
IPR027417--P-loop_NTPase

PROSITE

PS00674--AAA

Pfam

PF00004--AAA

Gene Ontology

GO:0005829--C:cytosol
GO:0031597--C:cytosolic proteasome complex
GO:0031595--C:nuclear proteasome complex
GO:0005634--C:nucleus
GO:0008540--C:proteasome regulatory particle, base subcomplex
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0004175--F:endopeptidase activity
GO:0036402--F:proteasome-activating ATPase activity
GO:0017025--F:TBP-class protein binding
GO:0030433--P:ER-associated ubiquitin-dependent protein catabolic process
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0045899--P:positive regulation of RNA polymerase II transcriptional preinitiation complex assembly