dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0001385 |
| Uniprot Accession | O42861; FFT3_SCHPO; Q9US92; |
| Genbank Protein ID | NP_593617.1; |
| Genbank Nucleotide ID | NM_001019048.2; |
| Protein Name | ATP-dependent helicase fft3 |
| Protein Synonyms/Alias | Fun thirty-related protein 3; |
| Gene Name | fft3 |
| Gene Synonyms/Alias | snf2SR;SPAC25A8.01c; |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID | 284812 |
| Functional Description (View all) |
DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization. Required for maintaining a heterochromatin chromatin structure at centromeres and subtelomeres by protecting these regions from euchromatin assembly. Enhances the nucleotide exchange activity of the pim1 guanine nucleotide exchange factor and abolishes histone-H3-mediated RanGAP inhibition. Involved in the construction of the centromeres. |
| Phosphorylation Sites |
dbPAF PTMs: 3 |
| Sequence (Fasta) | MDGKRKIEHT ADGTHYDATS NVKRKPIFPP FIADSLSEAT EKANVMGGGM NSRLQILSEM 60 SKRVQATAPI SSLEHFKQLS DISPSFTSSA NSINQPYNYS GSLENLVPTP SAGTPSQFMD 120 AQNPYGAVYN ALSQFSETEP KMPSYMDDEE ASDSLPLSLS SQSLSSQVTN QKPAPHRLTM 180 RERYAANNLT NGLQFTLPLS SRKTYEPEAD DDSNDDMYSD DDSNADRWAS RIDTAALKEE 240 VLKYMNRCST QDLADMTGCT LAEAEFMVAK RPFPDLESAL VVKQPRPVIP KGRRGRREKT 300 PLGPRLVGIC MEIMRGYFVV DALIRQCEQL GGKIQRGIEA WGLSNTATSD EGETSLVNFD 360 QMKSFGTPAN SSFITTPPAS FSPDIKLQDY QIIGINWLYL LYELKLAGIL ADEMGLGKTC 420 QTIAFFSLLM DKNINGPHLV IAPASTMENW LREFAKFCPK LKIELYYGSQ VEREEIRERI 480 NSNKDSYNVM LTTYRLAATS KADRLFLRNQ KFNVCVYDEG HYLKNRASER YRHLMSIPAD 540 FRVLLTGTPL QNNLKELISL LAFILPHVFD YGLKSLDVIF TMKKSPESDF ERALLSEQRV 600 SRAKMMMAPF VLRRKKSQVL DALPKKTRII EFCEFSEEER RRYDDFASKQ SVNSLLDENV 660 MKTNLDTNAN LAKKKSTAGF VLVQLRKLAD HPMLFRIHYK DDILRQMAKA IMNEPQYKKA 720 NELYIFEDMQ YMSDIELHNL CCKFPSINSF QLKDEPWMDA TKVRKLKKLL TNAVENGDRV 780 VLFSQFTQVL DILQLVMKSL NLKFLRFDGS TQVDFRQDLI DQFYADESIN VFLLSTKAGG 840 FGINLACANM VILYDVSFNP FDDLQAEDRA HRVGQKKEVT VYKFVVKDTI EEHIQRLANA 900 KIALDATLSG NAETVEAEDD DD 923 |
| Keyword | KW-0067--ATP-binding |
| Interpro | IPR014001--Helicase_ATP-bd |
| PROSITE | |
| Pfam | |
| Gene Ontology | GO:0000790--C:nuclear chromatin |