| Tag |
Content |
| dbPAF ID |
dbPAF-0001379 |
| Uniprot Accession |
O42832; SPB1_SCHPO;
|
| Genbank Protein ID |
NP_593129.1;
|
| Genbank Nucleotide ID |
NM_001018525.2;
|
| Protein Name |
AdoMet-dependent rRNA methyltransferase spb1 |
| Protein Synonyms/Alias |
2'-O-ribose RNA methyltransferase;S-adenosyl-L-methionine-dependent methyltransferase; |
| Gene Name |
spb1 |
| Gene Synonyms/Alias |
pmt2;SPAC1687.11; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.Functional Description
Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MGKSQKKTAK GRLDKWYKLA KEQGYRSRAA FKLVQLNQKY SFLEKAKVII DLCAAPGGWL 60
QVASKTCKPG SLIVGVDLAP IKPIPNCHTF VEDITSDKCR SQLRGYLKTW KADVVLHDGA 120
PNVGSAWLQD AYGQAQLVLM SMKLACEFLV AGGTFVTKVF RSRDYNNLLW VFKQLFNKVE 180
ATKPPSSRNV SAEIFVVCRG YKAPKKLDPR FTDPRTVFEE VQEPVTNVDA KVFHPEKRKR 240
SREGYADDDY TLHKTVLASE FVTANDPIQI LGTSAEIVFP KDDEECQRLY NLDVTTEEIL 300
LCCSDLQVLG KKEFRDILRW RLKIRDEMGI GKKVEDEQKT VVEEIPEMDE EERLDQELQD 360
LSEAERVKLK RERRKANQRK QREIVRMQMG MLAPMDIGLE HEAMGEDSLF GLATAEKHGL 420
KELENGTLPV TESVDEEVST DNEVEYDSDD ERDRLEADLD SMYSDYTKRK AESDVKYRVK 480
KARGDLDDEE WNGIDNGTES DDSQIAETNF ATPDKDRLTT SLLDKGSTKD GLSRKARMFF 540
DQDIFDGIED ADADVEIMSM NRAAIKKREA ELASQNNDDG SKGDQSEDSN DHIEVVPVAS 600
AHDEDDDWNS DSDNDENNVE IVTAEAMTLA QDIASRRKSK ADLIDEGYNR WSFQSKEGLP 660
DWFLDEETTV NKPNKPITKE AVLALREKMK ALNARPIKKV LEAQGRKKMR TIKRLQRVAK 720
KAEGISESGD MTESEKAKEI SRLVSRATKS KPKAKPTLVV AKGPNKGLKS RPKGVKGKYK 780
MVDSRMKKDL RAQKRLAKKG RR
803Fasta Sequence
>O42832|spb1|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MGKSQKKTAKGRLDKWYKLAKEQGYRSRAAFKLVQLNQKYSFLEKAKVIIDLCAAPGGWLQVASKTCKPGSLIVGVDLAPIKPIPNCHTFVEDITSDKCRSQLRGYLKTWKADVVLHDGAPNVGSAWLQDAYGQAQLVLMSMKLACEFLVAGGTFVTKVFRSRDYNNLLWVFKQLFNKVEATKPPSSRNVSAEIFVVCRGYKAPKKLDPRFTDPRTVFEEVQEPVTNVDAKVFHPEKRKRSREGYADDDYTLHKTVLASEFVTANDPIQILGTSAEIVFPKDDEECQRLYNLDVTTEEILLCCSDLQVLGKKEFRDILRWRLKIRDEMGIGKKVEDEQKTVVEEIPEMDEEERLDQELQDLSEAERVKLKRERRKANQRKQREIVRMQMGMLAPMDIGLEHEAMGEDSLFGLATAEKHGLKELENGTLPVTESVDEEVSTDNEVEYDSDDERDRLEADLDSMYSDYTKRKAESDVKYRVKKARGDLDDEEWNGIDNGTESDDSQIAETNFATPDKDRLTTSLLDKGSTKDGLSRKARMFFDQDIFDGIEDADADVEIMSMNRAAIKKREAELASQNNDDGSKGDQSEDSNDHIEVVPVASAHDEDDDWNSDSDNDENNVEIVTAEAMTLAQDIASRRKSKADLIDEGYNRWSFQSKEGLPDWFLDEETTVNKPNKPITKEAVLALREKMKALNARPIKKVLEAQGRKKMRTIKRLQRVAKKAEGISESGDMTESEKAKEISRLVSRATKSKPKAKPTLVVAKGPNKGLKSRPKGVKGKYKMVDSRMKKDLRAQKRLAKKGRR
|
| Keyword |
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
|
| Interpro |
IPR015507--rRNA-MeTfrase_E
IPR012920--rRNA_MeTfrase_Spb1_C
IPR024576--rRNA_MeTfrase_Spb1_DUF3381
IPR002877--rRNA_MeTrfase_FtsJ_dom
IPR029063--SAM-dependent_MTases
IPR028589--Spb1
|
| PROSITE |
|
| Pfam |
PF11861--DUF3381
PF01728--FtsJ
PF07780--Spb1_C
|
| Gene Ontology |
GO:0044732--C:mitotic spindle pole body
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0030687--C:preribosome, large subunit precursor
GO:0016435--F:rRNA (guanine) methyltransferase activity
GO:0070039--F:rRNA (guanosine-2'-O-)-methyltransferase activity
GO:0008650--F:rRNA (uridine-2'-O-)-methyltransferase activity
GO:0008649--F:rRNA methyltransferase activity
GO:0000453--P:enzyme-directed rRNA 2'-O-methylation
GO:0000466--P:maturation of 5
8S rRNA fr--m tricistronic rRNA transcript (SSU-rRNA, 5
8S rRNA, L--U-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5
8S rRNA, L--U-rRNA)
GO:0031167--P:rRNA methylation
|
