Tag |
Content |
dbPAF ID |
dbPAF-0001377 |
Uniprot Accession |
O42709; MCM10_SCHPO; |
Genbank Protein ID |
NP_596702.1; |
Genbank Nucleotide ID |
NM_001022626.2; |
Protein Name |
DNA replication licensing factor mcm10 |
Protein Synonyms/Alias |
Cdc23 protein;Minichromosome maintenance protein 10; |
Gene Name |
mcm10 |
Gene Synonyms/Alias |
cdc23;SPBC1347.10; |
Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
NCBI Taxa ID |
284812 |
Functional Description (View all) |
Required for DNA synthesis. Required for entry into or completion of S phase. Involved in DNA replication and seems to participate in the activation of the pre-replication complex (pre-RC) and in transcription elongation. May play a role as key coordinator in assembling the replication fork. Proposed to function at replication origins following the binding of the mcm2-7 complex prior to the recruitment of sna41. Probably is required to stimulate phosphorylation of the mcm2-7 complex by the dfp1-hsk1 kinase complex. May recruit the DNA polymerase alpha:primase complex to replication origins and is required to maintain it on chromatin independently of sna41. May have primase activity. Binds to single-stranded DNA.Functional Description
Required for DNA synthesis. Required for entry into or completion of S phase. Involved in DNA replication and seems to participate in the activation of the pre-replication complex (pre-RC) and in transcription elongation. May play a role as key coordinator in assembling the replication fork. Proposed to function at replication origins following the binding of the mcm2-7 complex prior to the recruitment of sna41. Probably is required to stimulate phosphorylation of the mcm2-7 complex by the dfp1-hsk1 kinase complex. May recruit the DNA polymerase alpha:primase complex to replication origins and is required to maintain it on chromatin independently of sna41. May have primase activity. Binds to single-stranded DNA.
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Phosphorylation Sites
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dbPAF PTMs: 1 Position | Peptides | Source | References ( PMIDs ) |
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64 | VRVLTVSSPSKLKSP | curated | 22817900 |
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Sequence (Fasta) | MHDPFIAEEN DLDLEEKRLQ RQLNEIQEKK RLRSAQKEAS SENAEVIQVP RSPPQQVRVL 60 TVSSPSKLKS PKRLILGIDK GKTGKDVSLG KGPRGPLPKP FHERLAEARN QERKRSDKLK 120 TMKKNRKQSF QRKRNILEDG KSEEEKFPMK CDEIDPYSRQ AIVIRYISDE VAKENIGGNQ 180 VYLIHQLLKL VRAPKFEAPE VDNYVVMGIV ASNSGTRETV NGNKYCMLTL TDLKWQLECF 240 LFGKAFERYW KIQSGTVIAL LNPEVLKPKN PDIGRFSLKL DSEYDVLLEI GRSKHLGYCS 300 SRRKSGELCK HWLDKRAGDV CEYHVDLAVQ RSMSTRTEFA SSMATMHEPR ARREKRFRGQ 360 GFQGYFAGEK YSAIPNAVAG LYDAEDAVQT ERERKERYKK QRAQAERERE ILVRLSKRCC 420 ASSSSSSNSN NLSTGMSMRT LGHQYLNLQG SGVKNLHDKG NPTALSKDSE IDSSTKKPSV 480 LASFNASIMN PKSSLPSFSN SAILGTNDAA SGTPVPQDTT STKVSPAVVF TSSPRIFSPQ 540 SLRKIGFDPT HSADASTTHS TATGLSRSGS LKNIKFRYEF TESDDEDDLE IVP
594Fasta Sequence
>O42709|mcm10|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) MHDPFIAEENDLDLEEKRLQRQLNEIQEKKRLRSAQKEASSENAEVIQVPRSPPQQVRVLTVSSPSKLKSPKRLILGIDKGKTGKDVSLGKGPRGPLPKPFHERLAEARNQERKRSDKLKTMKKNRKQSFQRKRNILEDGKSEEEKFPMKCDEIDPYSRQAIVIRYISDEVAKENIGGNQVYLIHQLLKLVRAPKFEAPEVDNYVVMGIVASNSGTRETVNGNKYCMLTLTDLKWQLECFLFGKAFERYWKIQSGTVIALLNPEVLKPKNPDIGRFSLKLDSEYDVLLEIGRSKHLGYCSSRRKSGELCKHWLDKRAGDVCEYHVDLAVQRSMSTRTEFASSMATMHEPRARREKRFRGQGFQGYFAGEKYSAIPNAVAGLYDAEDAVQTERERKERYKKQRAQAEREREILVRLSKRCCASSSSSSNSNNLSTGMSMRTLGHQYLNLQGSGVKNLHDKGNPTALSKDSEIDSSTKKPSVLASFNASIMNPKSSLPSFSNSAILGTNDAASGTPVPQDTTSTKVSPAVVFTSSPRIFSPQSLRKIGFDPTHSADASTTHSTATGLSRSGSLKNIKFRYEFTESDDEDDLEIVP
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Keyword |
KW-0131--Cell cycle KW-0132--Cell division KW-0181--Complete proteome KW-0235--DNA replication KW-0238--DNA-binding KW-0479--Metal-binding KW-0539--Nucleus KW-1185--Reference proteome KW-0862--Zinc KW-0863--Zinc-finger
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Interpro |
IPR015408--Znf_Mcm10/DnaG
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PROSITE |
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Pfam |
PF09329--zf-primase
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Gene Ontology |
GO:0005737--C:cytoplasm GO:0072686--C:mitotic spindle GO:0000790--C:nuclear chromatin GO:0043596--C:nuclear replication fork GO:0031298--C:replication fork protection complex GO:0035861--C:site of double-strand break GO:0003896--F:DNA primase activity GO:0003688--F:DNA replication origin binding GO:0003690--F:double-stranded DNA binding GO:0046872--F:metal ion binding GO:0003697--F:single-stranded DNA binding GO:0007049--P:cell cycle GO:0051301--P:cell division GO:0006270--P:DNA replication initiation GO:0006269--P:DNA replication, synthesis of RNA primer GO:1903934--P:positive regulation of DNA primase activity GO:1900264--P:positive regulation of DNA-directed DNA polymerase activity
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