| Tag |
Content |
| dbPAF ID |
dbPAF-0001367 |
| Uniprot Accession |
O36019; ATG13_SCHPO; Q9USA3;
|
| Genbank Protein ID |
NP_594750.1;
|
| Genbank Nucleotide ID |
NM_001020177.2;
|
| Protein Name |
Autophagy protein 13 |
| Protein Synonyms/Alias |
Meiotically up-regulated gene 78 protein; |
| Gene Name |
atg13 |
| Gene Synonyms/Alias |
mug78;SPAC4F10.07c; |
| Organism |
Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast) |
| NCBI Taxa ID |
284812 |
Functional Description
(View all) |
Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Autophagy functions to supply nitrogen and is activated when cells cannot access exogenous nitrogen, thus ensuring that they can adapt and subsequently propagate. Finally, atg13 is also required for glycogen storage during stationary phase and has a role in meiosis and sporulation.Functional Description
Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Autophagy functions to supply nitrogen and is activated when cells cannot access exogenous nitrogen, thus ensuring that they can adapt and subsequently propagate. Finally, atg13 is also required for glycogen storage during stationary phase and has a role in meiosis and sporulation. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 648 | QSPICARSATSAGLP | curated | 22817900 |
|
Sequence
(Fasta) | MPRLNTQLPR MYSAPPGHSK AVSTELNKDL SSVGGRSAKL GQVIHHCFYK TGLIILESRL 60
NVFGTSRPRE SSKNNKWFNL EIVETELYAE QFKIWKNIEL SPSRKIPPMV LHTYLDISDL 120
SKNQTLSVSD GTHSHAINFN NMSTMKIVLE RWIVNLDGEA LSTPLELAVL YKKLVVLFRS 180
LYTYTHLMPL WKLKSKIHKL RAHGTSLKVG CALSTDDVLS NDFLPISAPI SSSLGSSIAT 240
FSFSPVGTPA GDFRISVQYR KNCHFEVHDS DALLSNQLLS ADKHQLAASN NSQDFEDGKQ 300
YDQPPPSFAT RLAKQSDPNS LLQSEIQHLA SIESITAQAA PLVTIHPFKS PSLSASPGSN 360
FDNMSISPKV AVNRYIHRGP SATSLNKFSM ISDAASKSRA KLPPLTSGSL KLNTLDISNT 420
PNLRRFSSSF GPRERKESFS SRNRLPLVNH PIRSIFKHNV SENPITDHSE HAVYDSEFAS 480
KDDLSGFIQL LDSHAHHLNA SEGSKSSGSF PGKVQTLTSG ISPVAHPHNS LGSSNEIFDI 540
DTYNHSIDNS GSRFTEAVKH NLGNSSHSIM RHHTLGTLRS RPSFSEKSTF PAPLTSISQA 600
STFQGDNRSP STVIPHTQTE VPSANDTSKQ LASLHDMRKS QSPICARSAT SAGLPRFEYH 660
TSLSKSLEHS STPASLQATK TPSPSFVLEP GIPQEYKKHF DNLSEERRQC LTPSTPTYEY 720
YNEHNPNYDD DLLFTMTDMT LEPHDVSAIR LGSPKSDD
759Fasta Sequence
>O36019|atg13|Schizosaccharomyces pombe (strain 972 / ATCC 24843)(Fission yeast)
MPRLNTQLPRMYSAPPGHSKAVSTELNKDLSSVGGRSAKLGQVIHHCFYKTGLIILESRLNVFGTSRPRESSKNNKWFNLEIVETELYAEQFKIWKNIELSPSRKIPPMVLHTYLDISDLSKNQTLSVSDGTHSHAINFNNMSTMKIVLERWIVNLDGEALSTPLELAVLYKKLVVLFRSLYTYTHLMPLWKLKSKIHKLRAHGTSLKVGCALSTDDVLSNDFLPISAPISSSLGSSIATFSFSPVGTPAGDFRISVQYRKNCHFEVHDSDALLSNQLLSADKHQLAASNNSQDFEDGKQYDQPPPSFATRLAKQSDPNSLLQSEIQHLASIESITAQAAPLVTIHPFKSPSLSASPGSNFDNMSISPKVAVNRYIHRGPSATSLNKFSMISDAASKSRAKLPPLTSGSLKLNTLDISNTPNLRRFSSSFGPRERKESFSSRNRLPLVNHPIRSIFKHNVSENPITDHSEHAVYDSEFASKDDLSGFIQLLDSHAHHLNASEGSKSSGSFPGKVQTLTSGISPVAHPHNSLGSSNEIFDIDTYNHSIDNSGSRFTEAVKHNLGNSSHSIMRHHTLGTLRSRPSFSEKSTFPAPLTSISQASTFQGDNRSPSTVIPHTQTEVPSANDTSKQLASLHDMRKSQSPICARSATSAGLPRFEYHTSLSKSLEHSSTPASLQATKTPSPSFVLEPGIPQEYKKHFDNLSEERRQCLTPSTPTYEYYNEHNPNYDDDLLFTMTDMTLEPHDVSAIRLGSPKSDD
|
| Keyword |
KW-0002--3D-structure
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0469--Meiosis
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0749--Sporulation
KW-0813--Transport
|
| Interpro |
IPR018731--Autophagy-rel_p13
|
| PROSITE |
|
| Pfam |
PF10033--ATG13
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0019898--C:extrinsic component of membrane
GO:0000407--C:pre-autophagosomal structure
GO:0034045--C:pre-autophagosomal structure membrane
GO:0019887--F:protein kinase regulator activity
GO:0032147--P:activation of protein kinase activity
GO:0006914--P:autophagy
GO:0006995--P:cellular response to nitrogen starvation
GO:0000747--P:conjugation with cellular fusion
GO:0032258--P:CVT pathway
GO:0016236--P:macroautophagy
GO:0051321--P:meiotic cell cycle
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0034497--P:protein localization to pre-autophagosomal structure
GO:0030435--P:sporulation resulting in formation of a cellular spore
|
