dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001365
Uniprot Accession O35987; NSF1C_RAT;
Genbank Protein ID NP_114187.1;
Genbank Nucleotide ID NM_031981.2;
Protein Name NSFL1 cofactor p47
Protein Synonyms/Alias XY body-associated protein XY40;p97 cofactor p47;
Gene Name Nsfl1c
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER).
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
73APSDNRVTSFRDLIHcurated23984901
114VGPPRKKSPNELVDDdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16396499; 16641100; 16381945; 23193290; 22135298; 19366988;
140AVERVTKSPGETSKPdbPTM 3.0;PhosphoSitePlus;curated-; 16381945; 23193290; 22135298; 25532521
167APEEESAYVAGERRRPhosphoSitePlus;curated22135298; 22276854
176AGERRRHSGQDVHVVdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16641100; 16381945; 23193290; 22135298; 19366988; 22673903;
192KLWKTGFSLDNGDLRPhosphoSitePlus22135298
271APQVLNTSSPAQQAEcurated23984901
272PQVLNTSSPAQQAENcurated21630457; 23589303
Sequence
(Fasta)		MAEERQDALR EFVAVTGAEE DRARFFLESA GWDLQIALAS FYEDGGDEDI VTISQATPSS 60
VSRGTAPSDN RVTSFRDLIH DQDEEEEEEE GQRFYAGGSE RSGQQIVGPP RKKSPNELVD 120
DLFKGAKEHG AVAVERVTKS PGETSKPRPF AGGGYRLGAA PEEESAYVAG ERRRHSGQDV 180
HVVLKLWKTG FSLDNGDLRS YQDPSNAQFL ESIRRGEVPA ELRRLAHGGQ VNLDMEDHRD 240
EDFVKPKGAF KAFTGEGQKL GSTAPQVLNT SSPAQQAENE AKASSSILIN EAEPTTNIQI 300
RLADGGRLVQ KFNHSHRISD IRLFIVDARP AMAATSFVLM TTFPNKELAD ENQTLKEANL 360
LNAVIVQRLT 371
Keyword

KW-0002--3D-structure
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0333--Golgi apparatus
KW-0446--Lipid-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR012989--SEP_domain
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom
PROSITE

PS51399--SEP
PS50033--UBX
Pfam

PF08059--SEP
PF00789--UBX
Gene Ontology

GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0005795--C:Golgi stack
GO:0045111--C:intermediate filament cytoskeleton
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:1990730--C:VCP-NSFL1C complex
GO:0051117--F:ATPase binding
GO:0008289--F:lipid binding
GO:0008599--F:protein phosphatase type 1 regulator activity
GO:0043130--F:ubiquitin binding
GO:0000045--P:autophagosome assembly
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0031468--P:nuclear envelope reassembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0050790--P:regulation of catalytic activity