dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0001346 | ||||||||
| Uniprot Accession | O35923; BRCA2_RAT; | ||||||||
| Genbank Protein ID | |||||||||
| Genbank Nucleotide ID | |||||||||
| Protein Name | Breast cancer type 2 susceptibility protein homolog | ||||||||
| Protein Synonyms/Alias | Fanconi anemia group D1 protein homolog; | ||||||||
| Gene Name | Brca2 | ||||||||
| Gene Synonyms/Alias | Fancd1; | ||||||||
| Organism | Rattus norvegicus(Rat) | ||||||||
| NCBI Taxa ID | 10116 | ||||||||
| Functional Description (View all) |
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and DSS1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability, independently of its known role in homologous recombination (By similarity). | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
|
||||||||
| Sequence (Fasta) | MTVEYKRRPT FWEIFKARCS TADLGPISLN WFEELFSEAP PYNTEHPEES EYKPQGHEPQ 60 LFKTPQRNPS YHQFASTPIM FKEQSQTLPL DQSPFKELGN VVANSKRKHH SKKKARKDPV 120 VDVASLPLKA CPSESPCTPR CTQVAPQRRK PVVSGSLFYT PKLEETPKHI SESLGVEVDP 180 DMSWTSSLAT PPTLSSTVLI ARDEEAHRNA FPADSPASLK SYFSNHNESL KKNDRFIPSV 240 SDSENKSQQE AFSQGLEKML GDSSSKINRF RDCLRKPIPN VLEDGETAVD TSGEDSFSLC 300 FPKRRTRNLQ KTRMGKMKKK IFSETRTDGL SEEARGQADD KNSFALEIEP RDSEPLDPSV 360 TNQKPLYSQS GDISSEAGQC SDSIWSQPDP SGLNGTQTRK IPLLHISFHK QSILEDFIDM 420 KKEGTGSITF PHISSLPEPE KMFSEETLVD KEHEGQHLES LEDSISGKQM VSGTSQTACL 480 SPSIRKSIVK MREPLEETLD TVFSDSMTSS AFTEELDASA GGLEIHTACS QREDSLCPSS 540 VDTGSWPTTL TDTSATVKNA GLITTLKNKR RKFIYSVSDD ASHQGKKLQT QRQSELTNLS 600 APFEASAFEV PFPFTNVDSG IPDSSIKRSN LPNDPEEPSL SLTNSFVTAA SKEISYIHAL 660 ISQDLNDKEA ILSEEKPQPY TALEADFLSC LPERSCENDQ KSPKVSDRKE KVLVSACRPS 720 GRLAAAVQLS SISFDSQENP LGSHNVTSTL KLTPSPKTPL SKPVVVSRGK MCKMPEKLQC 780 KSCKDNIELS KNIPLGVNEM CVLSENSETP ELLPPLEYIT EVSSSVKSQF NQNTKIAVVQ 840 KDQKDSTFIS EVTVHMNSEE LFPEKENNFA FQVTNESNKP NIGSTVEFQE EDLSHAKGHS 900 LKNSPMTVDR DLDDEQAGQV LITEDSDSLA VVHDCTKKSR NTIEQHQKGT ADKDFKSNSS 960 LYLKSDGNND YLDKWSEFLD PLMNHKLGGS FRTASNKEIK LSEDNVKKSK MFFKDIEEQY 1020 PTSLDCIDTV STLQLANKKR LSEPHTFDLK SGTTVSTQCH SQSSVSHEDT HTAPQMLSSK 1080 QDFHSSHNLT PSQKAEITEL STILEESGSQ FEFTQFKNPS HIAQNNTSAV LGNQMAVVRT 1140 ASEEWKDVDL HLPLNPSSVG QIDHNKKFEC LVGVKQSSSH LLEDTCNQNT SCFLPIKEME 1200 FGGFCSALGT KLSVSNEALR KAMKLFSDIE NISEEPSTKV GPRGFSSCAH HDSVASVFKI 1260 KKQNTDKSFD EKSSKCQVTV QNNKEMTTCI LVDENPENYV KNIKQDNNYT GSQRNAYKLE 1320 NSDVSKSSTS GTVYINKGDS DLPFAAEKGN KYPESCTQYV REENAQIKES VSDLTCLEVM 1380 KAEETCHMKS SDKEQLPSDK MEQNMKEFNI SFQTASGKNI RVSKESLNKS VNILDQETED 1440 LTVTSDSLNS KILCGINKDK MHISCHKKSI NIKKVFEEHF PIGTVSQLPA LQQYPEYEIE 1500 SIKEPTLLSF HTASGKKVKI MQESLDKVKN LFDETQYVRK TTNFGHQESK PLKDREDYKE 1560 RLTLAYEKIE VTASKCEEMQ NFVSKQTEML PQQNDHMYRQ TENLTSNGSS PKVHGNIENK 1620 IEKNPRICCI CQSSYFVTED SALACYTGDS RKTCVGESSL SKGKKWLREQ SDKLGTRNTI 1680 EIQCVKEHTE DFAGNALYEH SLVIIRTEID TSHVSENQAS TLFSDPNVCH SYLSHSSFCH 1740 HDDMHNDSGY FLKDKIDSDV QPDMKNTEGN AIFPKISATK EIKLHPQTVN EECVQKLETN 1800 ASPYANKNIA IDSAMLDLRN CKVGSPVFIT THSQETVRMK EIFTDNCSKI VEQNRESKPD 1860 TCQTSCHKAL DNSEDFICPS SSGDVCINSP MAIFYPQSEQ ILQHNQSVSG LKKAATPPVS 1920 LETWDTCKSI RGSPQEVHPS RTYGFFSTAS GKAVQVSDAS LEKARQVFSE IDGDAKQLAS 1980 MVSLEGNEKS HHSVKRESSV VHNTHGVLSL RKTLPGNVSS FVFSGFSTAG GKLVTVSESA 2040 LHKVKGMLEE FDLIRTEHTL QHSPTPEDVS KIPPQPCLES RTPEYSVSSK LQKTYNDKSR 2100 SPSNYKESGS SGNTQSLEVS PQLSQMERKQ ETQSVLGTKV SQRKTNILEK KQNLPQNIKI 2160 ESNKMETFSD VSMKTNVGEY YSKEPENYFE TEAVEIAKAF MEDDELTDSE QTHAKCSLFA 2220 CPQNEALLNS RTRKRGGMAG VAVGQPPIKR SLLNEFDRII ESKGKSLTPS KSTPDGTIKD 2280 RRLFTHHMSL EPVTCGPFCS SKERQETQSP HVTSPAQGLQ SKEHPSRHSA VGKSSSNPTV 2340 SALRSERTRH SVSDKSTKVF VPPFKVKSRF HRDEHFDSKN VNLEGKNQKS ADGVSEDGND 2400 SDFPQFNKDL MSSLQNARDL QDIRIKNKER HHLCPQPGSL YLTKSSTLPR ISLQAAVGDS 2460 VPSACSPKQL YMYGVSKACI SVNSKNAEYF QFAIEDHFGK EALCAGKGFR LADGGWLIPS 2520 DDGKAGKEEF YRALCDTPGV DPKLISSVWV SNHYRWIVWK LAAMEFAFPK EFANRCLNPE 2580 RVLLQLKYRY DVEIDNSSRS ALKKILERDD TAAKTLVLCV SDIISLSTNV SETSGSKASS 2640 EDSNKVDTIE LTDGWYAVKA QLDPPLLALV KSGRLTVGQK IITQGAELVG SPDACAPLEA 2700 PDSLRLKISA NSTRPARWHS KLGFFHDPRP FPLPLSSLFS DGGNVGCVDV IVQRVYPLQW 2760 VEKTVSGSYI FRNEREEEKE ALRFAEAQQK KLEALFTKVH TELKEHEEDI AQRRVLSRAL 2820 TRQQVHALQD GAELYAAVQD ASDPEHLETC FSEEQLRALN NYRQMLSDKK QARIQSEFRK 2880 ALEAAEKEEG LSRDVSTVWK LRVTSYKKRE KSALLSIWRP SSDLPSLLTE GQRYRIYHLS 2940 VSKSKNKFEW PSIQLTATKR TQYQQLPVSS ETLLQLYQPR ELLPFSKLSD PAFQPPCSEV 3000 DVVGVVVSVV KPIGLAPLVY LSDECLHLLV VKFGIDLNED IKPRVLIAAS NLQWRPESTS 3060 RVPTLFAGNF SVFSASPKEA HFQERVTNMK HAIENIDTFY KEAEKKLIQV LKGDSPKWST 3120 PNKDPTREPY PASTCSASDL ASGGQLPRSS PTDQQSYRSP LSCCTPTGKS TPLAHSAWMA 3180 AKSCSGENEI EDPKTCRKKR ALDLLSRLPL PPPLSPVCTF VSPAAQKAFQ PPRSCGTKYP 3240 TPLKKEGPSS PWSRAPFQKA SGVSLLDCDS VADEELALLS TQALVPHSVG GSEQVFPSDS 3300 TRTEGPSAST EARPANRSKR ESLRDCRDDS DGKLAAETVP DYS 3344 |
||||||||
| Keyword | KW-0002--3D-structure |
||||||||
| Interpro | IPR015525--BRCA2 |
||||||||
| PROSITE | PS50138--BRCA2_REPEAT |
||||||||
| Pfam | PF09169--BRCA-2_helical |
||||||||
| Gene Ontology | GO:0005813--C:centrosome |