dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001345
Uniprot Accession O35921; EAA4_RAT; P97683;
Genbank Protein ID NP_114454.1;
Genbank Nucleotide ID NM_032065.1;
Protein Name Excitatory amino acid transporter 4
Protein Synonyms/Alias High-affinity neuronal glutamate transporter;Sodium-dependent glutamate/aspartate transporter;Solute carrier family 1 member 6;
Gene Name Slc1a6
Gene Synonyms/Alias Eaat4;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium (By similarity).
Phosphorylation Sites
dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
2------MSSHGNSLFPhosphoSitePlus;UniProt22135298; 22673903
40RTRLRLQTMTREHVRdbPTM 3.0;PhosphoSitePlus;curated17442044; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)
MSSHGNSLFL RESGAGGGCL QGLQDSLQQR ALRTRLRLQT MTREHVRRFL RRNAFILLTV 60
SAVIIGVSLA FALRPYQLTY RQIKYFSFPG ELLMRMLQML VLPLIVSSRV TGMASLDNKA 120
TGRMGMRAAV YYMVTTVIAV FIGILMVTII HPGKGSKEGL HREGRIETVP TADAFMDLVR 180
NMFPPNLVEA CFKQFKTQYS TRVVTRTIVR TDNGSELGAS ISPPSSAENE TSILENVTRA 240
LGTLQEVISF EETVPVPGSA NGINALGLVV FSVAFGLVIG GMKHKGRVLR DFFDSLNEAI 300
MRLVGIIIWY APVGILFLIA GKILEMEDMA VLGGQLGMYT LTVIVGLFLH AGGVLPLIYF 360
LVTHRNPFPF IGGILQALIT AMGTSSSSAT LPITFRCLEE GLGVDRRITR FVLPVGATVN 420
MDGTALYEAL AAIFIAQVNN YELNLGQITT ISITATAASV GAAGIPQAGL VTMVIVLTSV 480
GLPTEDITLI IAVDWFLDRL RTMTNVLGDS IGAAVIEHLS QRELELQEAE LTLPSLGKPY 540
KSLMAQAKGA SRGRGGNESV M 562
Keyword

KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0769--Symport
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport

Interpro

IPR001991--Na-dicarboxylate_symporter
IPR018107--Na-dicarboxylate_symporter_CS

PROSITE

PS00713--NA_DICARBOXYL_SYMP_1
PS00714--NA_DICARBOXYL_SYMP_2

Pfam

PF00375--SDF

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0008509--F:anion transmembrane transporter activity
GO:0005313--F:L-glutamate transmembrane transporter activity
GO:0017153--F:sodium:dicarboxylate symporter activity
GO:0098656--P:anion transmembrane transport
GO:0089711--P:L-glutamate transmembrane transport