dbPAF Protein Information
| Tag | Content | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0001343 | ||||||||||||||||
| Uniprot Accession | O35913; SO1A4_RAT; O55224; | ||||||||||||||||
| Genbank Protein ID | NP_571981.1; XP_008761573.1; | ||||||||||||||||
| Genbank Nucleotide ID | NM_131906.1; XM_008763351.1; | ||||||||||||||||
| Protein Name | Solute carrier organic anion transporter family member 1A4 | ||||||||||||||||
| Protein Synonyms/Alias | Brain digoxin carrier protein;Brain-specific organic anion transporter;OATP-B1;Sodium-independent organic anion-transporting polypeptide 2;Solute carrier family 21 member 5; | ||||||||||||||||
| Gene Name | Slco1a4 | ||||||||||||||||
| Gene Synonyms/Alias | Oatp1a4;Oatp2;Slc21a5; | ||||||||||||||||
| Organism | Rattus norvegicus(Rat) | ||||||||||||||||
| NCBI Taxa ID | 10116 | ||||||||||||||||
| Functional Description (View all) |
Mediates the Na(+)-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, estrone-3-sulfate, the cardiac glycosides ouabain and digoxin and thyroid hormones. May play an especially important role in the brain accumulation and toxicity of digoxin and in the hepatobiliary and renal excretion of cardiac glycosides. | ||||||||||||||||
| Phosphorylation Sites |
dbPAF PTMs: 3
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| Sequence (Fasta) | MGKSEKRVAT HGVRCFAKIK MFLLALTCAY VSKSLSGTYM NSMLTQIERQ FGIPTSIVGL 60 INGSFEIGNL LLIIFVSYFG TKLHRPIMIG VGCAVMGLGC FLISLPHFLM GQYEYETILP 120 TSNVSSNSFF CVENRSQTLN PTQDPSECVK EMKSLMWIYV LVGNIIRGIG ETPIMPLGIS 180 YIEDFAKSEN SPLYIGILET GMTIGPLIGL LLASSCANIY VDIESVNTDD LTITPTDTRW 240 VGAWWIGFLV CAGVNILTSF PFFFFPKTLP KEGLQENVDG TENAKEKKHR KKAKEEKRGI 300 TKDFFVFMKS LSCNPIYMLF ILISVLQFNA FINSFTFMPK YLEQQYGKST AEVVFLMGLY 360 MLPPICLGYL IGGLIMKKFK VTVKKAAHLA FWLCLSEYLL SFLSYVMTCD NFPVAGLTTS 420 YEGVQHQLYV ENKVLADCNT RCNCSTNTWD PVCGDNGLAY MSACLAGCEK SVGTGTNMVF 480 QNCSCIQSSG NSSAVLGLCN KGPDCANKLQ YFLIIAIFGC FIYSLAGIPG YMVLLRCIKS 540 EEKSLGVGLH AFCIRILAGI PAPIYFGALI DRTCLHWGTL KCGEPGACRM YDINSFRRLY 600 LGLPAALRGA SFVPAFFILR LTRTFQFPGD IESSKTDHAE MKLTLKESEC TEVLRSKVTE 660 D 662 |
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| Keyword | KW-1003--Cell membrane |
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| Interpro | IPR002350--Kazal_dom |
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| PROSITE | |||||||||||||||||
| Pfam | |||||||||||||||||
| Gene Ontology | GO:0005887--C:integral component of plasma membrane |