dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001333
Uniprot Accession O35867; NEB1_RAT;
Genbank Protein ID NP_445925.1;
Genbank Nucleotide ID NM_053473.2;
Protein Name Neurabin-1
Protein Synonyms/Alias Neurabin-I;Neural tissue-specific F-actin-binding protein I;PP1bp175;Protein phosphatase 1 regulatory subunit 9A;p180;
Gene Name Ppp1r9a
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction.
Phosphorylation Sites
 dbPAF PTMs: 23 (View all)
PositionPeptidesSourceReferences ( PMIDs )
160SGQNNRHSPKKEKAGPhosphoSitePlus22135298
187SNRGSSDSLDSLSPRcurated23712012; 21630457
192SDSLDSLSPRTEAVSPhosphoSitePlus;UniProt;curated22135298; 22673903; 23712012; 21630457
195LDSLSPRTEAVSPTVcurated23712012; 21630457
199SPRTEAVSPTVSQLScurated23712012
201RTEAVSPTVSQLSAVcurated23712012; 21630457
212LSAVFENSESPGAITcurated23712012; 21630457
300PSEERQLSTEAEDVTcurated23712012; 21630457
301SEERQLSTEAEDVTAcurated23712012; 21630457
312DVTAQPDTPDSTDKDPhosphoSitePlus;UniProt22135298; 22673903
372TGGGDLTSPDASASSPhosphoSitePlus;UniProt;curated22135298; 22673903; 23712012; 21630457; 23984901
461ANRKIKFSCAPIKVFdbPTM 3.0;PhosphoSitePlus;curated10504266; 16381945; 23193290; 12052877; 22135298; 22817900
841NIFERRPSPGEVSKGPhosphoSitePlus;curated22135298; 23712012; 21630457
866TSCQDGLSQDLNEAVPhosphoSitePlus22135298
916SSTDGEDSLERKNFTPhosphoSitePlus;UniProt22135298; 22673903
929FTFNDDFSPSSTSSAPhosphoSitePlus;UniProt22135298; 22673903
947GLGAEPKTPGLSQSLdbPTM 3.0;PhosphoSitePlus16641100; 16381945; 23193290; 22135298
951EPKTPGLSQSLALSSdbPTM 3.0;PhosphoSitePlus16641100; 16381945; 23193290; 22135298
953KTPGLSQSLALSSDEdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
957LSQSLALSSDESLDMPhosphoSitePlus;UniProt22135298; 22673903
Sequence
(Fasta)		MLKAESSGER TTLRSASPHR NAYRTEFQAL KSTFDKPKPD GEQKTKEGEG SQQSRGRKYG 60
SNVNRIKNLF MQMGMEPNEN AAIIAKTRGK GRPSSPQKRM KPKEFVEKTD GSVVKLESSV 120
SERISRFDTM HDGPSYAKFT ETRKMFERSG HESGQNNRHS PKKEKAGEAE PQDEWGGSKS 180
NRGSSDSLDS LSPRTEAVSP TVSQLSAVFE NSESPGAITP GKAENSNYSV TGHYPLNLPS 240
VTVTNLDTFG RLKDSNSRPS SNKQATDTEE PEKSEAVPVP EVAQKGTSLA SLPSEERQLS 300
TEAEDVTAQP DTPDSTDKDS PGEPSAESQA MPKSNTLSRP KEPLEDAEAN VVGSEAEQPQ 360
RRDLTGGGDL TSPDASASSC GKEVPEDSNS FEGSHVYMHS DYNVYRVRSR YNSDWGETGT 420
EQDEGDDSDE NNYYQPDMEY SEIVGLPQEE EIPANRKIKF SCAPIKVFNT YSNEDYDRRN 480
DDVDPVAASA EYELEKRVEK LELFPVELEK DEDGLGISII GMGVGADAGL EKLGIFVKTV 540
TEGGAAQRDG RIQVNDQIVE VDGISLVGVT QNFAATVLRN TKGNVRFVIG REKPGQVSEV 600
AQLISQTLEQ ERRQRELLER HYAQYDADDD ETGEYATDEE EDEVGPILPG GDMAIEVFEL 660
PENEDMFSPS DLDTSKLSHK FKELQIKHAV TEAEIQKLKT KLQAAENEKV RWELEKNQLQ 720
QNIEENKERM VKLESYWIEA QTLCHTVNEH LKETQSQYQA LEKKYNKAKK LIKDFQQKEL 780
DFIRRQEVER KKLEEVEKAH LVEVQGLQVR IRDLEAEVFR LLKQNGTQVN NNNNIFERRP 840
SPGEVSKGDT MENVEVKQTS CQDGLSQDLN EAVPETERLD SKALKTRAQL SVKNRRQRPT 900
RTRLYDSVSS TDGEDSLERK NFTFNDDFSP SSTSSADLSG LGAEPKTPGL SQSLALSSDE 960
SLDMIDDEIL DDGQSPKHTQ SQSRAVHEWS VQQVSHWLVG LSLDQYVSEF SAQNISGEQL 1020
LQLDGNKLKA LGMTSSQDRA LVKKKLKEMK MSLEKARKAQ EKMEKQREKL RRKEQEQMQR 1080
KSKKSEKMTS TTEQP 1096
Keyword

KW-0002--3D-structure
KW-0009--Actin-binding
KW-0965--Cell junction
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0903--Direct protein sequencing
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0770--Synapse
KW-0771--Synaptosome
Interpro

IPR029994--Neurabin-1
IPR001478--PDZ
IPR001660--SAM
IPR013761--SAM/pointed
PROSITE

PS50106--PDZ
PS50105--SAM_DOMAIN
Pfam

PF00595--PDZ
PF07647--SAM_2
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0030054--C:cell junction
GO:0030864--C:cortical actin cytoskeleton
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0043197--C:dendritic spine
GO:0044326--C:dendritic spine neck
GO:0030175--C:filopodium
GO:0030426--C:growth cone
GO:1990761--C:growth cone lamellipodium
GO:0030027--C:lamellipodium
GO:0031594--C:neuromuscular junction
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0014069--C:postsynaptic density
GO:0045202--C:synapse
GO:0051015--F:actin filament binding
GO:0051020--F:GTPase binding
GO:0044325--F:ion channel binding
GO:0008022--F:protein C-terminus binding
GO:0032403--F:protein complex binding
GO:0019904--F:protein domain specific binding
GO:0042803--F:protein homodimerization activity
GO:0019901--F:protein kinase binding
GO:0008157--F:protein phosphatase 1 binding
GO:0007015--P:actin filament organization
GO:0007568--P:aging
GO:0019722--P:calcium-mediated signaling
GO:0097237--P:cellular response to toxic substance
GO:0060079--P:excitatory postsynaptic potential
GO:1900272--P:negative regulation of long-term synaptic potentiation
GO:1904049--P:negative regulation of spontaneous neurotransmitter secretion
GO:0051497--P:negative regulation of stress fiber assembly
GO:0048666--P:neuron development
GO:0031175--P:neuron projection development
GO:0060999--P:positive regulation of dendritic spine development
GO:1900454--P:positive regulation of long term synaptic depression
GO:0010976--P:positive regulation of neuron projection development
GO:0045860--P:positive regulation of protein kinase activity
GO:0030833--P:regulation of actin filament polymerization
GO:0061001--P:regulation of dendritic spine morphogenesis
GO:0051489--P:regulation of filopodium assembly
GO:0051963--P:regulation of synapse assembly
GO:0051823--P:regulation of synapse structural plasticity