| Tag |
Content |
| dbPAF ID |
dbPAF-0001325 |
| Uniprot Accession |
O35828; CORO7_RAT; D3ZUE2;
|
| Genbank Protein ID |
NP_001178568.1;
|
| Genbank Nucleotide ID |
NM_001191639.1;
|
| Protein Name |
Coronin-7 |
| Protein Synonyms/Alias |
|
| Gene Name |
Coro7 |
| Gene Synonyms/Alias |
|
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity).Functional Description
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 7 |
Sequence
(Fasta) | MNRFKASKFR HMEARPSRRE AWISDIRAGT TATCGNHIKS SCSLIAFNSD RPGVLGIISL 60
EGHEENKRHV TYLGCHSDLV TDLDFSPFDD FLLASGSADR TIKLWRLSST GEALPSVPGV 120
VLGPEELPVD VLQFHPTADG VLVSTAGRTV KVWDVAKQQH LTELEAHKDL VQSAVWSRDG 180
ATVGTACKDK QLRIFDPRAR AQASQSTQAH ENNRDIRLAW TGIQEYLVST GFNQMREREA 240
KLWDTRVFSS ALASITLDTS PGSLIPLLDP DSGLLVLAGK GENQLYCYEV TPQQPALSPV 300
TQCILENALR GAALVPRQAL AVMNCEVLQV LQLSDTAIIP ISHRVPRKAV EFHEDLFPDT 360
AGSVPASDAH TWWAGDNQQV QKVSLNPAHR PHPRFTSSLL PTLEPSPNME QPAELPRADT 420
ELSEGFSSPS SLVSPSTPSS LGLSLSSTSG IGTSPSQRSL QSLLGPSSKF RHAEGTILHR 480
DSHITNLKGL NLTTPGESDG FCANRLRVAV PLLSSGGQVA VLELQKPGRL PDTALPTLQN 540
GAAVMDLVWD PFDPHRLAVA GEDARIRLWR VPPGGLKNVL TTPETVLTGH TEKIYSLRFH 600
PLAADVLASS SYDLTIRIWD LQAGTEQLRL QGHQDQIFSL AWSPDGKQLA TVCKDGRVRV 660
YDPRSSPLPL QDGPGPEGGR GARIVWVCNG GCLLVSGFDS RSERQLQLYM ADALAEGPSA 720
LLGLDVAPST LLPSYDPDTG LVLLTGKGDT RVFLYEVIPE APFFLECNSF TSPDPHKGFI 780
LLPKTECDIQ DVEFARCLRL RQTSLEPVAF RLPRVRKEFF QDDVFPDTAV TWASALDAKA 840
WFKGANGQPR LLSLQPPGMT PVSQAPREVP ARRTPSSAQY LEEKSDQQKK EELLNAMVAK 900
LGNREDPLPQ DSFEGVDEDE WD
923Fasta Sequence
>O35828|Coro7|Rattus norvegicus(Rat)
MNRFKASKFRHMEARPSRREAWISDIRAGTTATCGNHIKSSCSLIAFNSDRPGVLGIISLEGHEENKRHVTYLGCHSDLVTDLDFSPFDDFLLASGSADRTIKLWRLSSTGEALPSVPGVVLGPEELPVDVLQFHPTADGVLVSTAGRTVKVWDVAKQQHLTELEAHKDLVQSAVWSRDGATVGTACKDKQLRIFDPRARAQASQSTQAHENNRDIRLAWTGIQEYLVSTGFNQMREREAKLWDTRVFSSALASITLDTSPGSLIPLLDPDSGLLVLAGKGENQLYCYEVTPQQPALSPVTQCILENALRGAALVPRQALAVMNCEVLQVLQLSDTAIIPISHRVPRKAVEFHEDLFPDTAGSVPASDAHTWWAGDNQQVQKVSLNPAHRPHPRFTSSLLPTLEPSPNMEQPAELPRADTELSEGFSSPSSLVSPSTPSSLGLSLSSTSGIGTSPSQRSLQSLLGPSSKFRHAEGTILHRDSHITNLKGLNLTTPGESDGFCANRLRVAVPLLSSGGQVAVLELQKPGRLPDTALPTLQNGAAVMDLVWDPFDPHRLAVAGEDARIRLWRVPPGGLKNVLTTPETVLTGHTEKIYSLRFHPLAADVLASSSYDLTIRIWDLQAGTEQLRLQGHQDQIFSLAWSPDGKQLATVCKDGRVRVYDPRSSPLPLQDGPGPEGGRGARIVWVCNGGCLLVSGFDSRSERQLQLYMADALAEGPSALLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYEVIPEAPFFLECNSFTSPDPHKGFILLPKTECDIQDVEFARCLRLRQTSLEPVAFRLPRVRKEFFQDDVFPDTAVTWASALDAKAWFKGANGQPRLLSLQPPGMTPVSQAPREVPARRTPSSAQYLEEKSDQQKKEELLNAMVAKLGNREDPLPQDSFEGVDEDEWD
|
| Keyword |
KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0333--Golgi apparatus
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0853--WD repeat
|
| Interpro |
IPR015505--Coronin
IPR015048--DUF1899
IPR020472--G-protein_beta_WD-40_rep
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
|
| PROSITE |
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
|
| Pfam |
PF08953--DUF1899
PF00400--WD40
|
| Gene Ontology |
GO:0016023--C:cytoplasmic membrane-bounded vesicle
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0005802--C:trans-Golgi network
GO:0003779--F:actin binding
GO:0030041--P:actin filament polymerization
GO:0006895--P:Golgi to endosome transport
GO:0015031--P:protein transport
|
