| Tag |
Content |
| dbPAF ID |
dbPAF-0001324 |
| Uniprot Accession |
O35826; GLCNE_RAT;
|
| Genbank Protein ID |
NP_446217.1; XP_006238070.1; XP_006238071.1;
|
| Genbank Nucleotide ID |
NM_053765.2; XM_006238008.1; XM_006238009.2;
|
| Protein Name |
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase |
| Protein Synonyms/Alias |
UDP-GlcNAc-2-epimerase/ManAc kinase; |
| Gene Name |
Gne |
| Gene Synonyms/Alias |
Glcne; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. Plays an essential role in early development (By similarity).Functional Description
Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. Plays an essential role in early development (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 197 | LSAKNKDYMSIIRMW | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MEKNGNNRKL RVCVATCNRA DYSKLAPIMF GIKTEPAFFE LDVVVLGSHL IDDYGNTYRM 60
IEQDDFDINT RLHTIVRGED EAAMVESVGL ALVKLPDVLN RLKPDIMIVH GDRFDALALA 120
TSAALMNIRI LHIEGGEVSG TIDDSIRHAI TKLAHYHVCC TRSAEQHLIS MCEDHDRILL 180
AGCPSYDKLL SAKNKDYMSI IRMWLGDDVK CKDYIVALQH PVTTDIKHSI KMFELTLDAL 240
ISFNKRTLVL FPNIDAGSKE MVRVMRKKGI EHHPNFRAVK HVPFDQFIQL VAHAGCMIGN 300
SSCGVREVGA FGTPVINLGT RQIGRETGEN VLHVRDADTQ DKILQALHLQ FGKQYPCSKI 360
YGDGNAVPRI LKFLKSIDLQ EPLQKKFCFP PVKENISQDI DHILETLSAL AVDLGGTNLR 420
VAIVSMKGEI VKKYTQFNPK TYEERISLIL QMCVEAAAEA VKLNCRILGV GISTGGRVNP 480
QEGVVLHSTK LIQEWNSVDL RTPLSDTLHL PVWVDNDGNC AAMAERKFGQ GKGQENFVTL 540
ITGTGIGGGI IHQHELIHGS SFCAAELGHL VVSLDGPDCS CGSHGCIEAY ASGMALQREA 600
KKLHDEDLLL VEGMSVPKDE AVGALHLIQA AKLGNVKAQS ILRTAGTALG LGVVNILHTM 660
NPSLVILSGV LASHYIHIVR DVIRQQALSS VQDVDVVVSD LVDPALLGAA SMVLDYTTRR 720
IH
723Fasta Sequence
>O35826|Gne|Rattus norvegicus(Rat)
MEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPAFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKCKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERISLILQMCVEAAAEAVKLNCRILGVGISTGGRVNPQEGVVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAAMAERKFGQGKGQENFVTLITGTGIGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGNVKAQSILRTAGTALGLGVVNILHTMNPSLVILSGVLASHYIHIVRDVIRQQALSSVQDVDVVVSDLVDPALLGAASMVLDYTTRRIH
|
| Keyword |
KW-0021--Allosteric enzyme
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0418--Kinase
KW-0479--Metal-binding
KW-0511--Multifunctional enzyme
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0862--Zinc
|
| Interpro |
IPR000600--ROK
IPR020004--UDP-GlcNAc_Epase
IPR003331--UDP_GlcNAc_Epimerase_2
|
| PROSITE |
|
| Pfam |
PF02350--Epimerase_2
PF00480--ROK
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0004553--F:hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0046872--F:metal ion binding
GO:0009384--F:N-acylmannosamine kinase activity
GO:0008761--F:UDP-N-acetylglucosamine 2-epimerase activity
GO:0046835--P:carbohydrate phosphorylation
GO:0006045--P:N-acetylglucosamine biosynthetic process
GO:0046380--P:N-acetylneuraminate biosynthetic process
GO:0006047--P:UDP-N-acetylglucosamine metabolic process
|
