dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001322
Uniprot Accession O35821; MBB1A_RAT;
Genbank Protein ID NP_113856.1; XP_006246864.1;
Genbank Nucleotide ID NM_031668.1; XM_006246802.1;
Protein Name Myb-binding protein 1A
Protein Synonyms/Alias PAR-interacting protein;PIP;
Gene Name Mybbp1a
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter.
Phosphorylation Sites
 dbPAF PTMs: 27 (View all)
PositionPeptidesSourceReferences ( PMIDs )
6--MAEMKSPTKAEPAcurated23984901
8MAEMKSPTKAEPASPPhosphoSitePlus;curated22135298; 23712012; 21630457
14PTKAEPASPAEAPQGPhosphoSitePlus;UniProt;curated22135298; 22673903; 25532521; 22817900; 21630457; 22276854
77YALKRLITGLGVGREcurated23984901
456WIIHRLVSLVDHLHLcurated23984901
981VYSASLESLLTKRNScurated23984901
1020VVQHVAGSSRPRHQAcurated23984901
1065VLGKTTQTLQTLGEAcurated23984901
1131QGNHSSGSSRLYDLYcurated23984901
1164VKDIPSDSQSPISTKcurated25532521; 23712012; 21630457
1166DIPSDSQSPISTKRKPhosphoSitePlus;UniProt;curated22135298; 22673903; 25532521; 23712012; 21630457; 23589303;
1170DSQSPISTKRKKKGFcurated23712012; 21630457
1234RKRVKANTPSQVNGVcurated23984901
1253SPAPNNPTLSPSTPPcurated23712012; 21630457
1255APNNPTLSPSTPPAKdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16641100; 16381945; 23193290; 22135298; 19366988; 22673903;
1257NNPTLSPSTPPAKTPcurated22817900; 21630457
1258NPTLSPSTPPAKTPKdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated16641100; 16381945; 23193290; 22135298; 19366988; 22817900;
1274QKKKEKLSQVNGSTPcurated23712012; 21630457
1279KLSQVNGSTPVSPVEcurated23712012; 21630457
1280LSQVNGSTPVSPVEPcurated23712012; 21630457
Sequence
(Fasta)		MAEMKSPTKA EPASPAEAPQ GDRRSLLEHS REFLDFFWDI AKPDQETRLR ATEKLLEYLR 60
TRPSDSEMKY ALKRLITGLG VGREAARPCY SLALAQLLQS FEDIQLCDIL GQIQEKYNLQ 120
AMNKAMMRPT LFANLFGVLA LFQSGRLVKD KEALMKCVRL LKILSHHYNH LQGQPVKALV 180
DILSEVPESM FQEILPKVLK GDMKVILSSP KYLELFLLAR QRVPAELESL VGSVDLFSED 240
NIPSLVNILK VAANSVKKEQ KLPDVALNLL RLALQENKFE RFWKEVLEEG LLKKPSYTSS 300
YMCFRLLGAS LPLLSDEQLQ LVMRGDLIRH FGEHMVVSKS QNPLRFIPEI SAYVGTFLEG 360
CQDDPKRQFT VMVAFTAITN QGLPVMPTFW RVTRFLNTEA LQNYVTWLRD MFLQPDLDSL 420
VDFSTANQKR VQVASLNVPE RTVFRLRKWI IHRLVSLVDH LHLEKDEAVV EQIARFCLFH 480
AFFKTKKATP QIPETKQHFS FPLEDGNRGV IVSAFFSLLQ TLSVKFRQTP DLAENGKPWT 540
YRLVQLADML LKHNRNVANV TPLTAQQRQA WDQMMSTLKE LEAQSSETRA IAFQHLLLLV 600
GLHLFKSPAE SCDVLGDIQT CIKKSMEQNL RRSRSRAKAS QEPVWVEVMV EILLSLLAQP 660
SNLMRQVVRS VFGHVCSHLT PRGLQLILAV LNPETNEDEE DNVVVTDTDE KQLKHGEDAD 720
SDSEDSKNSE SDVDSEDGEE SEEEDRDKDV DPGFRQQLME VLQAGNALGG EEEEEEELGD 780
EAMMALDQNL ASLFAEQKMR IQARHEEKNK LQKEKQLRRD FQIRALDLIE VLVTKQPEHP 840
LILELLEPLL NIIQRSMRSR GSTKQEQDLL HKTARIFMHH LCRARHYCHE VEPGAEALHA 900
QVERLVQQAG NQADASVALY YFNASLYLLR VLKGNTTKRY QDGQKLEGAD IKSEPKDSEV 960
QTTSCLDLDF VTRVYSASLE SLLTKRNSPL TIPMFLDLFS RYPVICKNLL PIVVQHVAGS 1020
SRPRHQAQAC LLLQKALSAR ELRVCFEDPE WEQLISQVLG KTTQTLQTLG EAQSKGEHQR 1080
ELSILELLNT VFRIVNHEKL SVDLTAFLGM LQGKQQKLQQ NLQQGNHSSG SSRLYDLYWQ 1140
AMNLLGVQRP KSEKKNVKDI PSDSQSPIST KRKKKGFLPE TKKRKKLKSE GTTSEKKAAS 1200
QQDAVTEGAM PAATGKDQPP STGKKRRKRV KANTPSQVNG VTVAKSPAPN NPTLSPSTPP 1260
AKTPKVQKKK EKLSQVNGST PVSPVEPESK KHQKALSTKE VKRRSSQSAL PKKRARLSLV 1320
SRSPSLLQSG IRKRRVARRR VQTP 1345
Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0090--Biological rhythms
KW-0164--Citrullination
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR016024--ARM-type_fold
IPR007015--DNA_pol_V
PROSITE
Pfam

PF04931--DNA_pol_phi
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0042564--C:NLS-dependent protein nuclear import complex
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0001047--F:core promoter binding
GO:0003887--F:DNA-directed DNA polymerase activity
GO:0044822--F:poly(A) RNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0042149--P:cellular response to glucose starvation
GO:0032922--P:circadian regulation of gene expression
GO:0072332--P:intrinsic apoptotic signaling pathway by p53 class mediator
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006913--P:nucleocytoplasmic transport
GO:0001649--P:osteoblast differentiation
GO:2000210--P:positive regulation of anoikis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0022904--P:respiratory electron transport chain
GO:0006351--P:transcription, DNA-templated