dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001318
Uniprot Accession O35806; LTBP2_RAT;
Genbank Protein ID NP_067597.2;
Genbank Nucleotide ID NM_021586.2;
Protein Name Latent-transforming growth factor beta-binding protein 2
Protein Synonyms/Alias
Gene Name Ltbp2
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
May play an integral structural role in elastic-fiber architectural organization and/or assembly. May be involved in the assembly, secretion and targeting of TGF- beta to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGF-beta. May have a structural role in the extra cellular matrix (ECM) (By similarity).
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
493DPVPEDNSVETRASHPhosphoSitePlus;UniProt;curated22135298; 22673903; 25458152
Sequence
(Fasta)
MRAPTTVRCS GRIQRARWRG FLPLVLALLM GTSHAQRDSV GRYEPASRDA NRLWRPVGNH 60
PAAAAAKVYS LFREPDAPVP GLSPSEWNQP GQGIPGRLAE AEARRPSRAQ QLRRVQSPVQ 120
TRRSNPRGQQ PPAARTAHSV VRLATPQRPA AARRGRLTGR NVCGGQCCPG WTTSNSTNHC 180
IKPVCQPPCQ NRGSCSRPQL CICRSGFRGA RCEEVIPEEE FDPQNARPVP RRSVEGAPGP 240
HRSSEARGSL VTRIQPLLPP LPPPPSRTLS QTRPLQQHAG LSRTVRRYPA TGTNGQLMSN 300
ALPSGPGPEL RDSSQQAAHM NHLSHPWGLN LTEKIKKIKV VFTPTICKQT CARGRCANTC 360
EKGDTTTLYS QGGHGHDPKS GFRIYFCQIP CLNGGRCIGR DECWCPANST GKFCHLPVPQ 420
PDREPPGRGS QHRALLEGPL KQSTFTLPLS NQLASVNPSL VKVQMQHPPE ASVQIHQVAR 480
VRGEVDPVPE DNSVETRASH RPHGSSGHSH WASNSIPARA GEAPRPPPVP SRHYGLLGQC 540
YLSTVNGQCA NPLGELTSQE DCCGSVGTSW GVTSCAPCPP RPAFPVIENG QLECPQGYKR 600
LNLSHCQDIN ECLTLGLCKD SECVNTRGSY LCTCRPGLML DPSRSRCVSD KAVSMKQGLC 660
YRSMVSGTCT LPLVQRITKQ ICCCSRVGKA WGSKCEHCPL PGTEAFREIC PAGHGYAYSS 720
SDIRLSMRKA EEEELASPVR EQRQQSSGPP PGAAERQPLR AATATWIEAE TLPDKGDSRA 780
IQITTSAPHL PARVPGDATG RPTPSLPGQG IPEGPAEEQV IPSSDVLVTH GPPGFDPCFA 840
GASNICGPGT CVKLPNGYRC VCSPGYQLHP SQDYCTDDNE CLRNPCEGRG RCVNSVGSYS 900
CLCYPGYTLA TLGDTQECQD VDECEQPGVC SGGRCSNTEG SYHCECDQGY VMVRRGHCQD 960
INECRHPGTC PDGRCVNSPG SYTCLACEEG YIGQSGNCVD MNECLTPGIC AHGRCINMEG 1020
SFRCSCEPGY ELTPDKKGCR DVDECASRAS CPTGLCLNTE GSFTCSACQS GYWVNEDGTA 1080
CEDLDECAFP GVCPTGVCTN TVGSFSCKDC DRGFRPSPLG NSCEDVDECE GPQNSCLGGE 1140
CKNTDGSYQC LCPQGFQLAN GTVCEDVDEC VGEEHCAPHG ECLNSPGSFF CLCAPGFASA 1200
EGGTRCQDVD ECATTEPCLG GHCVNTEGSF NCLCETGFQP APDSGECVDI DECANDTVCG 1260
NHGFCDNTDG SFRCLCDQGF ETSPSGWECV DVNECELMLA VCGDALCENV EGSFLCLCAS 1320
DLEEYDAEEG HCRPRVAGAQ RIPEVPTEEQ AAGLTGMECY AEHNGGPPCS QILGQNSTQA 1380
ECCSTQGARW GETCDPCPSE DSVEFSELCP SGQGYIPVEG AWTFGQAMYT DADECILFGP 1440
ALCQNGRCLN TVPGYICLCN PGYHYDAVSR KCQDHNECQD LACENGECVN TEGSFHCFCS 1500
PPLILDLSGQ RCVNSTSSSE DFPDHDIHMD ICWKKVTNDV CSQPLRGHHT TYTECCCQDG 1560
EAWSQQCALC PPRSSEVYAQ LCNVARIEAE REAGIHFRPG YEYGPGPDDL PETLYGPDGA 1620
PFYNYLGPED TVPEPPFSNT ASHLGDNTPI LEPPLQPSEL QPPAIQNPLA SFEGLQAEEC 1680
GILNGCENGR CVRVREGYTC DCFEGFQLDT ALMACVDVNE CEDLNGAARL CAHGHCENTE 1740
GSYRCHCSPG YVAEPGPPHC AAKE 1765
Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0325--Glycoprotein
KW-0340--Growth factor binding
KW-0358--Heparin-binding
KW-0379--Hydroxylation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal

Interpro

IPR001881--EGF-like_Ca-bd_dom
IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR000152--EGF-type_Asp/Asn_hydroxyl_site
IPR018097--EGF_Ca-bd_CS
IPR009030--Growth_fac_rcpt_N_dom
IPR017878--TB_dom

PROSITE

PS00070--ALDEHYDE_DEHYDR_CYS
PS00010--ASX_HYDROXYL
PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
PS01187--EGF_CA
PS51364--TB

Pfam

PF00008--EGF
PF07645--EGF_CA
PF00683--TB

Gene Ontology

GO:0005576--C:extracellular region
GO:0005509--F:calcium ion binding
GO:0008201--F:heparin binding
GO:0007179--P:transforming growth factor beta receptor signaling pathway