dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001316
Uniprot Accession O35793; GREM1_RAT;
Genbank Protein ID NP_062155.1;
Genbank Nucleotide ID NM_019282.3;
Protein Name Gremlin-1
Protein Synonyms/Alias Cysteine knot superfamily 1, BMP antagonist 1;Down-regulated in Mos-transformed cells protein;
Gene Name Grem1
Gene Synonyms/Alias Cktsf1b1;Drm;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
77GEEVLESSQEALHVTcurated25532521
Sequence
(Fasta)		MNRTAYTVGA LLLLLGTLLP AAEGKKKGSQ GAIPPPDKAQ HNDSEQTQSP PQPGSRTRGR 60
GQGRGTAMPG EEVLESSQEA LHVTERKYLK RDWCKTQPLK QTIHEEGCNS RTIINRFCYG 120
QCNSFYIPRH IRKEEGSFQS CSFCKPKKFT TMMVTLNCPE LQPPTKKKRV TRVKQCRCIS 180
IDLD 185
Keyword

KW-0181--Complete proteome
KW-0202--Cytokine
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
Interpro

IPR006207--Cys_knot_C
IPR004133--DAN
IPR017159--Gremlin-1/2
PROSITE
Pfam

PF03045--DAN
Gene Ontology

GO:0009986--C:cell surface
GO:0005615--C:extracellular space
GO:0030297--F:transmembrane receptor protein tyrosine kinase activator activity
GO:0006915--P:apoptotic process
GO:0001658--P:branching involved in ureteric bud morphogenesis
GO:0002042--P:cell migration involved in sprouting angiogenesis
GO:0007267--P:cell-cell signaling
GO:0030199--P:collagen fibril organization
GO:0048263--P:determination of dorsal identity
GO:0030326--P:embryonic limb morphogenesis
GO:0003337--P:mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0043066--P:negative regulation of apoptotic process
GO:0030514--P:negative regulation of BMP signaling pathway
GO:1900158--P:negative regulation of bone mineralization involved in bone maturation
GO:0046851--P:negative regulation of bone remodeling
GO:1900155--P:negative regulation of bone trabecula formation
GO:0090191--P:negative regulation of branching involved in ureteric bud morphogenesis
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0030308--P:negative regulation of cell growth
GO:0032331--P:negative regulation of chondrocyte differentiation
GO:0002689--P:negative regulation of leukocyte chemotaxis
GO:0090027--P:negative regulation of monocyte chemotaxis
GO:0033689--P:negative regulation of osteoblast proliferation
GO:0090291--P:negative regulation of osteoclast proliferation
GO:0060394--P:negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0090190--P:positive regulation of branching involved in ureteric bud morphogenesis
GO:2000727--P:positive regulation of cardiac muscle cell differentiation
GO:0008284--P:positive regulation of cell proliferation
GO:0042346--P:positive regulation of NF-kappaB import into nucleus
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1900086--P:positive regulation of peptidyl-tyrosine autophosphorylation
GO:0002092--P:positive regulation of receptor internalization
GO:0051973--P:positive regulation of telomerase activity
GO:0003257--P:positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0009954--P:proximal/distal pattern formation
GO:0010717--P:regulation of epithelial to mesenchymal transition
GO:0051893--P:regulation of focal adhesion assembly
GO:0060676--P:ureteric bud formation