dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001312
Uniprot Accession O35783; CALU_RAT;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Calumenin
Protein Synonyms/Alias CBP-50;Crocalbin;
Gene Name Calu
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).
Phosphorylation Sites
dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
35VHHEPQLSDKVHNDAcurated23712012; 21630457
47NDAQNFDYDHDAFLGPhosphoSitePlus;curated22135298; 23712012; 21630457
261TKDWILPSDYDHAEAcurated23712012
277ARHLVYESDQDKDGKcurated23984901
Sequence
(Fasta)
MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQNFDYDHD AFLGAEEAKS 60
FGQLTPEESK EKLGMIVDKI DTDKDGFVTE GELKSRIKHA QKKYIYDNVE NQWQEFDMNQ 120
DGLISWDEYR NVTYGTYLDD PDPDDGFNYK PIMVRDERRF KMADQDGDLI ATKEEFTAFL 180
HPEEYDYMKD IVLQETMEDI DQNADGFIDL EEYIGDMYSH DGNADEPQWV KTEREQFVEF 240
RDKNRDGKMD KEETKDWILP SDYDHAEAEA RHLVYESDQD KDGKLTKEEI VDKYDLFVGS 300
QATDFGEALV RHDEF 316
Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0703--Sarcoplasmic reticulum
KW-0964--Secreted
KW-0732--Signal

Interpro

IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom

PROSITE

PS00018--EF_HAND_1
PS50222--EF_HAND_2

Pfam

PF13202--EF-hand_5
PF13499--EF-hand_7

Gene Ontology

GO:0005788--C:endoplasmic reticulum lumen
GO:0005576--C:extracellular region
GO:0043231--C:intracellular membrane-bounded organelle
GO:0042470--C:melanosome
GO:0033018--C:sarcoplasmic reticulum lumen
GO:0005509--F:calcium ion binding
GO:0019899--F:enzyme binding
GO:0004857--F:enzyme inhibitor activity
GO:0043086--P:negative regulation of catalytic activity
GO:0014012--P:peripheral nervous system axon regeneration
GO:0014070--P:response to organic cyclic compound