| Tag |
Content |
| dbPAF ID |
dbPAF-0001310 |
| Uniprot Accession |
O35779; BHE41_RAT;
|
| Genbank Protein ID |
|
| Genbank Nucleotide ID |
|
| Protein Name |
Class E basic helix-loop-helix protein 41 |
| Protein Synonyms/Alias |
|
| Gene Name |
Bhlhb3 |
| Gene Synonyms/Alias |
Sharp1; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity (By similarity).Functional Description
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 122 | NGERSLKSPVQADLD | curated | 25532521 |
|
Sequence
(Fasta) | MDEGIPHLQE RQLLEHRDFI GLDYSSLYMC KPKRSLKRDD TKDTYKLPHR LIEKKRRDRI 60
NECIAQLKDL LPEHLKLTTL GHLEKAVVLE LTLKHLKALT ALTEQQHQKI IALQNGERSL 120
KSPVQADLDA FHSGFQTCAK EVLQYLARFE SWTPREPRCA QLVSHLHAVA TQLLTPQVTP 180
GRGPGRAPCS AGAAAASGSE RVARCVPVIQ RTQPGTEPEH DTDTDSGYGG EAEQGRAAVK 240
QEPPGDPSAA PKRLKLEARG ALLGPEPALL GSLVALGGGA PFAQPAAAPF CLPFYLLSPS 300
AAAYVQPWLD KSGLDKYLYP AAAAPFPLLY PGIPAAAAAA AAAAFPCLSS VLSPPPEKAG 360
SAAGAPFLAH EVAPPGSLRP QHAHSRTHLP HAVNPESSQE DATQPAKDAP
411Fasta Sequence
>O35779|Bhlhb3|Rattus norvegicus(Rat)
MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSLKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPVQADLDAFHSGFQTCAKEVLQYLARFESWTPREPRCAQLVSHLHAVATQLLTPQVTPGRGPGRAPCSAGAAAASGSERVARCVPVIQRTQPGTEPEHDTDTDSGYGGEAEQGRAAVKQEPPGDPSAAPKRLKLEARGALLGPEPALLGSLVALGGGAPFAQPAAAPFCLPFYLLSPSAAAYVQPWLDKSGLDKYLYPAAAAPFPLLYPGIPAAAAAAAAAAFPCLSSVLSPPPEKAGSAAGAPFLAHEVAPPGSLRPQHAHSRTHLPHAVNPESSQEDATQPAKDAP
|
| Keyword |
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR011598--bHLH_dom
IPR003650--Orange_dom
|
| PROSITE |
PS50888--BHLH
PS51054--ORANGE
|
| Pfam |
PF07527--Hairy_orange
PF00010--HLH
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0003714--F:transcription corepressor activity
GO:0007623--P:circadian rhythm
GO:0009649--P:entrainment of circadian clock
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0007399--P:nervous system development
GO:0048168--P:regulation of neuronal synaptic plasticity
GO:0006351--P:transcription, DNA-templated
|
