| Tag |
Content |
| dbPAF ID |
dbPAF-0001253 |
| Uniprot Accession |
O35567; PUR9_RAT; Q6IN16;
|
| Genbank Protein ID |
NP_112276.2;
|
| Genbank Nucleotide ID |
NM_031014.2;
|
| Protein Name |
Bifunctional purine biosynthesis protein PURH |
| Protein Synonyms/Alias |
|
| Gene Name |
Atic |
| Gene Synonyms/Alias |
Purh; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.Functional Description
Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MASSQLALFS VSDKTGLVEF ARNLASLGLS LVASGGTAKA IRDAGLAVRD VSELTGFPEM 60
LGGRVKTLHP AVHAGILARN IPEDAADMAR LDFNLIRVVV CNLYPFVKTV ASPDVTVEAA 120
VEQIDIGGVT LLRAAAKNHA RVTVVCEPED YGAVAAEMQG SGNKDTSLET RRHLALKAFT 180
HTAQYDEAIS DYFRRQYSKG ISQMPLRYGM NPHQTPAQLY TLKPKLPITV LNGAPGFINL 240
CDALNAWQLV TELRGAVDIP AAASFKHVSP AGAAVGVPLS EDEARVCMVY DLYPTLTPLA 300
IAYARARGAD RMSSFGDFVA LSDVCDVPTA KIISREVSDG IVAPGYEEEA LKILSKKKNG 360
SYCVLQMDQS YKPDENEVRT LFGLRLSQKR NNGVVDKSLF SNIVTKNKDL PESALRDLIV 420
ATIAVKYTQS NSVCYAKDGQ VIGIGAGQQS RIHCTRLAGD KANSWWLRHH PRVLSMKFKA 480
GVKRAEVSNA IDQYVTGTIG EGEDLVKWKA LFEEVPELLT EAEKKEWVDK LSGVSVSSDA 540
FFPFRDNVDR AKRSGVAYIV APSGSTADKV VIEACDELGI VLAHTDLRLF HH
593Fasta Sequence
>O35567|Atic|Rattus norvegicus(Rat)
MASSQLALFSVSDKTGLVEFARNLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDAADMARLDFNLIRVVVCNLYPFVKTVASPDVTVEAAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYGAVAAEMQGSGNKDTSLETRRHLALKAFTHTAQYDEAISDYFRRQYSKGISQMPLRYGMNPHQTPAQLYTLKPKLPITVLNGAPGFINLCDALNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDLYPTLTPLAIAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNGSYCVLQMDQSYKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAGVKRAEVSNAIDQYVTGTIGEGEDLVKWKALFEEVPELLTEAEKKEWVDKLSGVSVSSDAFFPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH
|
| Keyword |
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0511--Multifunctional enzyme
KW-0658--Purine biosynthesis
KW-1185--Reference proteome
KW-0808--Transferase
|
| Interpro |
IPR024051--AICAR_Tfase_dom
IPR024050--AICAR_Tfase_insert_dom
IPR002695--AICARFT_IMPCHas
IPR016193--Cytidine_deaminase-like
IPR011607--MGS-like_dom
|
| PROSITE |
|
| Pfam |
PF01808--AICARFT_IMPCHas
PF02142--MGS
|
| Gene Ontology |
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0003937--F:IMP cyclohydrolase activity
GO:0004643--F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0042803--F:protein homodimerization activity
GO:0006189--P:'de novo' IMP biosynthetic process
GO:0003360--P:brainstem development
GO:0021549--P:cerebellum development
GO:0021987--P:cerebral cortex development
GO:0009235--P:cobalamin metabolic process
GO:0046452--P:dihydrofolate metabolic process
GO:0009116--P:nucleoside metabolic process
GO:0031100--P:organ regeneration
GO:0010035--P:response to inorganic substance
GO:0009259--P:ribonucleotide metabolic process
GO:0046654--P:tetrahydrofolate biosynthetic process
|
