dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001252
Uniprot Accession O35552; F263_RAT; O35096; O35553; O35554; O35555; O35556; O35557; Q9QWQ5; Q9QWQ6;
Genbank Protein ID NP_476476.1; XP_006254254.1; XP_006254255.1; XP_006254257.1; XP_006254258.1; XP_006254259.1; XP_006254260.1; XP_008770072.1;
Genbank Nucleotide ID NM_057135.1; XM_006254192.2; XM_006254193.2; XM_006254195.2; XM_006254196.2; XM_006254197.2; XM_006254198.2; XM_008771850.1;
Protein Name 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Protein Synonyms/Alias
Gene Name Pfkfb3
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Synthesis and degradation of fructose 2,6-bisphosphate.
Phosphorylation Sites
 dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
490NPLMRRNSVTPLASPPhosphoSitePlus;curated22135298; 25532521; 22276854
492LMRRNSVTPLASPEPcurated25532521
496NSVTPLASPEPTKKPcurated22276854
Sequence
(Fasta)		MPLELTQSRV QKIWVPVDHR PSLPRSCGPK LTNSPTVIVM VGLPARGKTY ISKKLTRYLN 60
WIGVPTKVFN VGEYRREAVK QYSSYNFFRP DNEEAMRVRK QCALAALRDV KSYLTKEGGQ 120
IAVFDATNTT RERRHMILHF AKENDFKAFF IESVCDDPTV VASNIMEVKI SSPDYKDCNS 180
AEAMDDFMKR INCYEASYQP LDPDKCDRDL SFIKVIDVGR RFLVNRVQDH IQSRIVYYLM 240
NIHVQPRTIY LCRHGENEYN VQGKIGGDSG LSSRGKKFAN ALSKFVEEQN LKDLRVWTSQ 300
LKSTIQTAEA LRLPYEQWKA LNEIDAGVCE ELTYEEIRDT YPEEYALREQ DKYYYRYPTG 360
ESYQDLVQRL EPVIMELERQ ENVLVICHQA VLRCLLAYFL DKSAEEMPYL KCPLHTVLKL 420
TPVAYGCRVE SIYLNVESVS THRERSEAVK IQHFASVVRP SSYTELDFLS VESAKQDAKK 480
GPNPLMRRNS VTPLASPEPT KKPRINSFEE HVASTSAALP SCLPPEVPTQ LPGQPLLGKA 540
CLRTVCHIFS KFSPY 556
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0418--Kinase
KW-0511--Multifunctional enzyme
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR003094--6Pfruct_kin
IPR013079--6Phosfructo_kin
IPR013078--His_Pase_superF_clade-1
IPR029033--His_PPase_superfam
IPR027417--P-loop_NTPase
IPR001345--PG/BPGM_mutase_AS
PROSITE

PS00175--PG_MUTASE
Pfam

PF01591--6PF2K
PF00300--His_Phos_1
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0003873--F:6-phosphofructo-2-kinase activity
GO:0005524--F:ATP binding
GO:0004331--F:fructose-2,6-bisphosphate 2-phosphatase activity
GO:0007420--P:brain development
GO:0016311--P:dephosphorylation
GO:0006003--P:fructose 2,6-bisphosphate metabolic process
GO:0006000--P:fructose metabolic process
GO:0006110--P:regulation of glycolytic process