dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0001250 |
| Uniprot Accession | O35550; RABE1_RAT; P70609; |
| Genbank Protein ID | NP_061997.1; |
| Genbank Nucleotide ID | NM_019124.1; |
| Protein Name | Rab GTPase-binding effector protein 1 |
| Protein Synonyms/Alias | Rabaptin-5;Rabaptin-5alpha; |
| Gene Name | Rabep1 |
| Gene Synonyms/Alias | Rabpt5;Rabpt5a; |
| Organism | Rattus norvegicus(Rat) |
| NCBI Taxa ID | 10116 |
| Functional Description (View all) |
Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MAQPGPAPQP DVSLQQRVAE LEKINAEFLR AQQQLEQEFN QKRAKFKELY LAKEEDLKRQ 60 NAVLQAAQDD LGHLRTQLWE AQAEMENIKA IATVSENTKQ EAIDEVKRQW REEVASLQAV 120 MKETVRDYEH QFHLRLEQER AQWAQYRESA DREIADLRRR LSEGQEEENL ENEMKKAQED 180 AEKLRSVVMP MEKEIAALKD KLTEAEDKIK ELEASKVKEL NHYLEAEKSC RTDLEMYVAV 240 LNTQKSVLQE DAEKLRKELH EVCHLLEQER QQHNQLKHTW QKANDQFLES QRLLMRDMQR 300 MEIVLTSEQL RQVEELKKKD QEEDEQQRIN KGKDNKKIDT EEEVKIPVVC ALTQEESSTP 360 LSNEEEHLDS THGSVHSLDA DLLLPSGDPF SKSDNDMFKE GLRRAQSTDS LGTSSSLQSK 420 ALGYNYKAKS AGNLDESDFG PLVGADSVSE NFDTVSLGSL QMPSGFMLTK DQERAIKAMT 480 PEQEETASLL SSVTQGMESA YVSPSGYRLV SETEWNLLQK EVHNAGNKLG RRCDMCSNYE 540 KQLQGIQIQE AETRDQVKKL QLMLRQANDQ LEKTMKEKQE LEDFLRQSAE DSSHQISALV 600 LRAQASEVLL EELQQSFSQA KRDVQEQMAV LMQSREQVSE ELVRLQKDND SLQGKHSLHV 660 SLQLAEDFIL PDTVQVLREL VLKYRENIVH VRTAADHMEE KLKAEILFLK EQIQAEQCLK 720 ENLEETLQLE IENCKEEIAS ISSLKAELER IKVEKGQLES TLREKSQQLE SLQEIKVNLE 780 EQLKKETAAK ATVEQLMFEE KNKAQRLQTE LDVSEQVQRD FVKLSQTLQV QLERIRQADS 840 LERIRAILND TKLTDINQLP ET 863 |
| Keyword | KW-0007--Acetylation |
| Interpro | IPR003914--Rabaptin |
| PROSITE | |
| Pfam | |
| Gene Ontology | GO:0005769--C:early endosome |