| Tag |
Content |
| dbPAF ID |
dbPAF-0001249 |
| Uniprot Accession |
O35548; MMP16_RAT; O35541;
|
| Genbank Protein ID |
NP_542954.1;
|
| Genbank Nucleotide ID |
NM_080776.1;
|
| Protein Name |
Matrix metalloproteinase-16 |
| Protein Synonyms/Alias |
|
| Gene Name |
Mmp16 |
| Gene Synonyms/Alias |
|
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. The short isoform efficiently converts progelatinase A to the intermediate form but not to the mature one. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.Functional Description
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. The short isoform efficiently converts progelatinase A to the intermediate form but not to the mature one. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 80 | LAAMQQFYGINMTGK | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MILLAFSSGR RLDFVHRSGV FFFQTLLWIL CATVCGTEQY FNVEVWLQKY GYLPPTDPRM 60
SVLRSAETMQ SALAAMQQFY GINMTGKVDR NTIDWMKKPR CGVPDQTRGS SKFNIRRKRY 120
ALTGQKWQHK HITYSIKNVT PKVGDPETRR AIRRAFDVWQ NVTPLTFEEV PYSELENGKR 180
DVDITIIFAS GFHGDRSPFD GEGGFLAHAY FPGPGIGGDT HFDSDEPWTL GNPNHDGNDL 240
FLVAVHELGH ALGLEHSNDP TAIMAPFYQY METDNFKLPN DDLQGIQKIY GPPDKIPPPT 300
RPLPTVPPHR SVPPADPRKN DRPKPPRPPT GRPSYPGAKP NICDGNFNTL AILRREMFVF 360
KDQWFWRVRN NRVMDGYPMQ ITYFWRGLPP SIDAVYENSD GNFVFFKGNK YWVFKDTTLQ 420
PGYPHDLITL GNGIPPHGID SAIWWEDVGK TYFFKGDRYW RYSEEMKTMD PGYPKPITIW 480
KGIPESPQGA FVHKENGFTY FYKGKEYWKF NNQILKVEPG YPRSILKDFM GCDGPTDRDK 540
EGLSPPDDVD IVIKLDNTAS TVKAIAIVIP CILALCLLVL VYTVFQFKRK GTPRHILYCK 600
RSMQEWV
608Fasta Sequence
>O35548|Mmp16|Rattus norvegicus(Rat)
MILLAFSSGRRLDFVHRSGVFFFQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFNIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRRAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDRSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSVPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGNGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITIWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRDKEGLSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV
|
| Keyword |
KW-0025--Alternative splicing
KW-0106--Calcium
KW-1003--Cell membrane
KW-0165--Cleavage on pair of basic residues
KW-0177--Collagen degradation
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0272--Extracellular matrix
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0865--Zymogen
|
| Interpro |
IPR000585--Hemopexin-like_dom
IPR018487--Hemopexin-like_repeat
IPR018486--Hemopexin_CS
IPR024079--MetalloPept_cat_dom
IPR028697--MMP16
IPR001818--Pept_M10_metallopeptidase
IPR021190--Pept_M10A
IPR021805--Pept_M10A_metallopeptidase_C
IPR016293--Pept_M10A_stromelysin-type
IPR021158--Pept_M10A_Zn_BS
IPR006026--Peptidase_Metallo
IPR002477--Peptidoglycan-bd-like
|
| PROSITE |
PS00546--CYSTEINE_SWITCH
PS00024--HEMOPEXIN
PS51642--HEMOPEXIN_2
PS00142--ZINC_PROTEASE
|
| Pfam |
PF11857--DUF3377
PF00045--Hemopexin
PF00413--Peptidase_M10
PF01471--PG_binding_1
|
| Gene Ontology |
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0005578--C:proteinaceous extracellular matrix
GO:0005509--F:calcium ion binding
GO:0004222--F:metalloendopeptidase activity
GO:0008270--F:zinc ion binding
GO:0030574--P:collagen catabolic process
|
