| Tag |
Content |
| dbPAF ID |
dbPAF-0001236 |
| Uniprot Accession |
O35485; VEGFB_RAT; O54881; Q6DGF3;
|
| Genbank Protein ID |
NP_446001.1; XP_006230972.1; XP_006230973.1;
|
| Genbank Nucleotide ID |
NM_053549.1; XM_006230910.2; XM_006230911.2;
|
| Protein Name |
Vascular endothelial growth factor B |
| Protein Synonyms/Alias |
|
| Gene Name |
Vegfb |
| Gene Synonyms/Alias |
Vrf; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis (By similarity).Functional Description
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 24 | ACTQAPVSQFDGPSH | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MSPLLRRLLL VALLQLACTQ APVSQFDGPS HQKKVVSWID VYARATCQPR EVVVPLSMEL 60
MGNVVKQLVP SCVTVQRCGG CCPDDGLECV PIGQHQVRMQ ILMIQYPSSQ LGEMSLEEHS 120
QCECRPKRKE SAVKPDRVAI PHHRPQPRSV LSWDSAPGAS SPADIIHPTP APGPSAHAAP 180
SAVSALIPGP AVAAADAAAS SIAKGGA
208Fasta Sequence
>O35485|Vegfb|Rattus norvegicus(Rat)
MSPLLRRLLLVALLQLACTQAPVSQFDGPSHQKKVVSWIDVYARATCQPREVVVPLSMELMGNVVKQLVPSCVTVQRCGGCCPDDGLECVPIGQHQVRMQILMIQYPSSQLGEMSLEEHSQCECRPKRKESAVKPDRVAIPHHRPQPRSVLSWDSAPGASSPADIIHPTPAPGPSAHAAPSAVSALIPGPAVAAADAAASSIAKGGA
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0339--Growth factor
KW-0358--Heparin-binding
KW-0497--Mitogen
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR029034--Cystine-knot_cytokine
IPR023581--PD_growth_factor_CS
IPR000072--PDGF/VEGF_dom
|
| PROSITE |
PS00249--PDGF_1
PS50278--PDGF_2
|
| Pfam |
PF00341--PDGF
|
| Gene Ontology |
GO:0005615--C:extracellular space
GO:0005622--C:intracellular
GO:0016020--C:membrane
GO:0042056--F:chemoattractant activity
GO:0008201--F:heparin binding
GO:0001525--P:angiogenesis
GO:0060048--P:cardiac muscle contraction
GO:0060976--P:coronary vasculature development
GO:0050930--P:induction of positive chemotaxis
GO:0010629--P:negative regulation of gene expression
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0051781--P:positive regulation of cell division
GO:0001938--P:positive regulation of endothelial cell proliferation
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0060754--P:positive regulation of mast cell chemotaxis
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0030949--P:positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035470--P:positive regulation of vascular wound healing
GO:0006493--P:protein O-linked glycosylation
GO:0042493--P:response to drug
|
