| Tag |
Content |
| dbPAF ID |
dbPAF-0001232 |
| Uniprot Accession |
O35462; ANGP2_RAT; B1WBY0; Q548N5;
|
| Genbank Protein ID |
NP_604449.1;
|
| Genbank Nucleotide ID |
NM_134454.1;
|
| Protein Name |
Angiopoietin-2 |
| Protein Synonyms/Alias |
|
| Gene Name |
Angpt2 |
| Gene Synonyms/Alias |
Agpt2; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).Functional Description
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 189 | NKLQDKNSFLEKKVL | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MWQIVFLTFG CDLVLASAYN NFRKSVDSTG RRQYQVQNGP CSYTFLLPET DSCRSSSSPY 60
MSNAVQRDAP LDYDDSVQRL QVLENILENN TQWLMKLENY IQDNMKKEMV EIQQNVVQNQ 120
TAVMIEIGTS LLNQTAAQTR KLTDVEAQVL NQTTRLELQL LQHSISTNKL EKQILDQTSE 180
INKLQDKNSF LEKKVLDMED KHSVQLQSMK EQKDQLQVLV SKQSSVIDEL EKKLVTATVN 240
NSVLQKQQHD LMETVNSLLT MMSSPDYKSS VAVPKEEKTT FRDCAEIFKS GLTTSGIYTL 300
TFPNSTEEVK AYCDMDMGGG GWTVIQHRED GSVDFQRTWK EYKEGFGSPL GEYWLGNEFV 360
SQLTSGHRYV LKIQLKDWEG SEAHSLYEHF YLSGEESNYR IHLTGLTGTA GKISSISQPG 420
SDFSTKDSDN DKCICKCSQM LTGGWWFDAC GPSNLNGQYY PQKQNTNKFN GIKWYYWKGS 480
GYSLKATTMM IRPADF
497Fasta Sequence
>O35462|Angpt2|Rattus norvegicus(Rat)
MWQIVFLTFGCDLVLASAYNNFRKSVDSTGRRQYQVQNGPCSYTFLLPETDSCRSSSSPYMSNAVQRDAPLDYDDSVQRLQVLENILENNTQWLMKLENYIQDNMKKEMVEIQQNVVQNQTAVMIEIGTSLLNQTAAQTRKLTDVEAQVLNQTTRLELQLLQHSISTNKLEKQILDQTSEINKLQDKNSFLEKKVLDMEDKHSVQLQSMKEQKDQLQVLVSKQSSVIDELEKKLVTATVNNSVLQKQQHDLMETVNSLLTMMSSPDYKSSVAVPKEEKTTFRDCAEIFKSGLTTSGIYTLTFPNSTEEVKAYCDMDMGGGGWTVIQHREDGSVDFQRTWKEYKEGFGSPLGEYWLGNEFVSQLTSGHRYVLKIQLKDWEGSEAHSLYEHFYLSGEESNYRIHLTGLTGTAGKISSISQPGSDFSTKDSDNDKCICKCSQMLTGGWWFDACGPSNLNGQYYPQKQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF
|
| Keyword |
KW-0037--Angiogenesis
KW-0106--Calcium
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR028844--Ang-2
IPR014716--Fibrinogen_a/b/g_C_1
IPR014715--Fibrinogen_a/b/g_C_2
IPR002181--Fibrinogen_a/b/g_C_dom
IPR020837--Fibrinogen_CS
|
| PROSITE |
PS00514--FIBRINOGEN_C_1
PS51406--FIBRINOGEN_C_2
|
| Pfam |
PF00147--Fibrinogen_C
|
| Gene Ontology |
GO:0042995--C:cell projection
GO:0005615--C:extracellular space
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0001525--P:angiogenesis
GO:0071363--P:cellular response to growth factor stimulus
GO:0007281--P:germ cell development
GO:0072012--P:glomerulus vasculature development
GO:0060135--P:maternal process involved in female pregnancy
GO:0016525--P:negative regulation of angiogenesis
GO:0043537--P:negative regulation of blood vessel endothelial cell migration
GO:0010812--P:negative regulation of cell-substrate adhesion
GO:0050928--P:negative regulation of positive chemotaxis
GO:0031100--P:organ regeneration
GO:0045766--P:positive regulation of angiogenesis
GO:0014823--P:response to activity
GO:0009749--P:response to glucose
GO:0001666--P:response to hypoxia
GO:0009612--P:response to mechanical stimulus
GO:0014070--P:response to organic cyclic compound
GO:0009314--P:response to radiation
GO:0048014--P:Tie signaling pathway
|
