| Tag |
Content |
| dbPAF ID |
dbPAF-0001231 |
| Uniprot Accession |
O35460; ANGP1_RAT; Q8K4Q4;
|
| Genbank Protein ID |
NP_445998.1;
|
| Genbank Nucleotide ID |
NM_053546.1;
|
| Protein Name |
Angiopoietin-1 |
| Protein Synonyms/Alias |
|
| Gene Name |
Angpt1 |
| Gene Synonyms/Alias |
|
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.Functional Description
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MTVFLSFAFF AAILTHIGCS NQRRSPENGG RRYNRIQHGQ CAYTFILPEH DGNCRESATE 60
QYNTNALQRD APHVETDFSS QKLQHLEHVM ENYTQWLQKL ENYIVENMKS EMAQIQQNAV 120
QNHTATMLEI GTSLLSQTAE QTRKLTDVET QVLNQTSRLE IQLLENSLST YELEKQLLQQ 180
TNEILKIQEK NSLLEHKILE MEGKHKEELD TLKEEKENLQ GLVTRQTFII QELEKQLSRA 240
TSNNSVLQKQ QLELMDTVHN LVSLCTKEVL LKGGKREEEK PFRDCADVYQ AGFNKSGIYT 300
IYFNNMPEPK KVFCNMDVNE GGWTVIQHRE DGSLDFQRGW KEYKMGFGNP SGEYWLGNEF 360
IFAITSQRQY MLRIELMDWE GNRAYSQYDR FHIGNQKQNY RLYLKGHTGT AGKQSSLILH 420
GADFSTKDAD NDNCMCKCAL MLTGGWWFDA CGPSNLNGMF YTAGQNHGKL NGIKWHYFKG 480
PSYSLRSTTM MIRPLDF
498Fasta Sequence
>O35460|Angpt1|Rattus norvegicus(Rat)
MTVFLSFAFFAAILTHIGCSNQRRSPENGGRRYNRIQHGQCAYTFILPEHDGNCRESATEQYNTNALQRDAPHVETDFSSQKLQHLEHVMENYTQWLQKLENYIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYELEKQLLQQTNEILKIQEKNSLLEHKILEMEGKHKEELDTLKEEKENLQGLVTRQTFIIQELEKQLSRATSNNSVLQKQQLELMDTVHNLVSLCTKEVLLKGGKREEEKPFRDCADVYQAGFNKSGIYTIYFNNMPEPKKVFCNMDVNEGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNQKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF
|
| Keyword |
KW-0037--Angiogenesis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR028843--Ang-1
IPR014716--Fibrinogen_a/b/g_C_1
IPR014715--Fibrinogen_a/b/g_C_2
IPR002181--Fibrinogen_a/b/g_C_dom
IPR020837--Fibrinogen_CS
|
| PROSITE |
PS00514--FIBRINOGEN_C_1
PS51406--FIBRINOGEN_C_2
|
| Pfam |
PF00147--Fibrinogen_C
|
| Gene Ontology |
GO:0005615--C:extracellular space
GO:0001525--P:angiogenesis
GO:0030154--P:cell differentiation
GO:0072012--P:glomerulus vasculature development
GO:0043066--P:negative regulation of apoptotic process
GO:0031100--P:organ regeneration
GO:0001541--P:ovarian follicle development
GO:0051260--P:protein homooligomerization
GO:0043627--P:response to estrogen
GO:0001666--P:response to hypoxia
GO:0033552--P:response to vitamin B3
GO:0048014--P:Tie signaling pathway
|
