dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001222
Uniprot Accession O35431; APBA2_RAT;
Genbank Protein ID NP_113968.1;
Genbank Nucleotide ID NM_031780.1;
Protein Name Amyloid beta A4 precursor protein-binding family A member 2
Protein Synonyms/Alias Adapter protein X11beta;Neuron-specific X11L protein;Neuronal Munc18-1-interacting protein 2;Mint-2;
Gene Name Apba2
Gene Synonyms/Alias Mint2;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP.
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
540GINPEDLSQKEYSDIPhosphoSitePlus22135298
Sequence
(Fasta)		MAHRKRQSTA SSMLDHRARP GPIPHDQEPE NEDTELPLES YVPTGLELGT LRPDSPTPEE 60
QECHNHSPDG DSSSDYVNNT SEEEDYDEGL PEEEEGVTYY IRYCPEDDSY LEGMDCNGEE 120
YLAHGAHPVD TDECQEAVED WTDSVGPHTH SHGAENSQEY PDSHLPIPED DPTVLEVHDQ 180
EEDGHYCPSK ESYQDYYPPE TNGNTGGASP YRMRRGDGDL EEQEEDIDQI VAEIKMSLSM 240
TSITSASEAS PEHMPELDPG DSTEACSPSD TGRGPSRQEA RPKSLNLPPE VKHSGDPQRG 300
LKTKTRTPEE RPKWPQEQVC NGLEQPRKQQ RSDLNGPTDN NNIPETKKVA SFPSFVAVPG 360
PCEPEDLIDG IIFAANYLGS TQLLSERNPS KNIRMMQAQE AVSRVKRMQK AAKIKKKANS 420
EGDAQTLTEV DLFISTQRIK VLNADTQETM MDHALRTISY IADIGNIVVL MARRRMPRSA 480
SQDCIETTPG AQEGKKQYKM ICHVFESEDA QLIAQSIGQA FSVAYQEFLR ANGINPEDLS 540
QKEYSDIINT QEMYNDDLIH FSNSENCKEL QLEKHKGEIL GVVVVESGWG SILPTVILAN 600
MMNGGPAARS GKLSIGDQIM SINGTSLVGL PLATCQGIIK GLKNQTQVKL NIVSCPPVTT 660
VLIKRPDLKY QLGFSVQNGI ICSLMRGGIA ERGGVRVGHR IIEINGQSVV ATAHEKIVQA 720
LSNSVGEIHM KTMPAAMFRL LTGQETPLYI 751
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
Interpro

IPR030529--Apba2
IPR001478--PDZ
IPR011993--PH/PTB_dom
IPR006020--PTB/PI_dom
PROSITE

PS50106--PDZ
PS01179--PID
Pfam

PF00595--PDZ
PF00640--PID
Gene Ontology

GO:0005886--C:plasma membrane
GO:0008021--C:synaptic vesicle
GO:0001540--F:beta-amyloid binding
GO:0005546--F:phosphatidylinositol-4,5-bisphosphate binding
GO:0001701--P:in utero embryonic development
GO:0007626--P:locomotory behavior
GO:0035264--P:multicellular organism growth
GO:0015031--P:protein transport
GO:0010468--P:regulation of gene expression
GO:0016079--P:synaptic vesicle exocytosis