dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001221
Uniprot Accession O35430; APBA1_RAT;
Genbank Protein ID NP_113967.1;
Genbank Nucleotide ID NM_031779.2;
Protein Name Amyloid beta A4 precursor protein-binding family A member 1
Protein Synonyms/Alias Adapter protein X11alpha;Neuron-specific X11 protein;Neuronal Munc18-1-interacting protein 1;Mint-1;
Gene Name Apba1
Gene Synonyms/Alias Mint1;X11;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-AAP.
Phosphorylation Sites
dbPAF PTMs: 13
PositionPeptidesSourceReferences ( PMIDs )
81ECLARSASTESGFHNcurated25532521
243LHHYDERSDGESDSPPhosphoSitePlus;UniProt22135298; 22673903
247DERSDGESDSPEKEAPhosphoSitePlus;UniProt22135298; 22673903
249RSDGESDSPEKEAEFPhosphoSitePlus;UniProt22135298; 22673903
264APYPRMDSYEQEEDIPhosphoSitePlus;UniProt;curated22135298; 22673903; 25532521
286KQSMSSQSLDKAAEDPhosphoSitePlus22135298
306QDLERAPTPGGGHPDPhosphoSitePlus;curated22135298; 25532521
314PGGGHPDSPGLPAPAPhosphoSitePlus;UniProt22135298; 22673903
330QQQRVVGTPGGSEVGdbPTM 3.0;PhosphoSitePlus19054758; 16381945; 23193290; 22135298
372RTIRSPYTPDEPKEPPhosphoSitePlus22135298
388WVMRQDISPTRDCDDPhosphoSitePlus22135298
570RRMPRSNSQENVEASPhosphoSitePlus;UniProt;curated22135298; 22673903; 23984901
629GINPEDLSQKEYSDLPhosphoSitePlus22135298
Sequence
(Fasta)
MNHLEGSAEV EVADEAPGGE VNESVEADLE HPEVEEEQQP SPPPPAGHAP EDHRAHPAPP 60
PPPPPQEEEE ERGECLARSA STESGFHNHT DTAEGDVLAA ARDGYEAERA QDADDESAYA 120
VQYRPEAEEY TEQAEAEHAE AAQRRALPNH LHFHSLEHEE AMNAAYSGYV YTHRLFHRAE 180
DEPYAEPYAD YGGLQEHVYE EIGDAPELEA RDGLRLYERE RDEAAAYRQE ALGARLHHYD 240
ERSDGESDSP EKEAEFAPYP RMDSYEQEED IDQIVAEVKQ SMSSQSLDKA AEDMPEAEQD 300
LERAPTPGGG HPDSPGLPAP AGQQQRVVGT PGGSEVGQRY SKEKRDAISL AIKDIKEAIE 360
EVKTRTIRSP YTPDEPKEPI WVMRQDISPT RDCDDQRPVD GDSPSPGSSS PLGAESSITP 420
LHPGDPTEAS TNKESRKSLA SFPTYVEVPG PCDPEDLIDG IIFAANYLGS TQLLSDKTPS 480
KNVRMMQAQE AVSRIKTAQK LAKSRKKAPE GESQPMTEVD LFISTQRIKV LNADTQEPMM 540
DHPLRTISYI ADIGNIVVLM ARRRMPRSNS QENVEASHPS QDAKRQYKMI CHVFESEDAQ 600
LIAQSIGQAF SVAYQEFLRA NGINPEDLSQ KEYSDLLNTQ DMYNDDLIHF SKSENCKDVF 660
IEKQKGEILG VVIVESGWGS ILPTVIIANM MHGGPAEKSG KLNIGDQIMS INGTSLVGLP 720
LSTCQSIIKG LKNQSRVKLN IVRCPPVTTV LIRRPDLRYQ LGFSVQNGII CSLMRGGIAE 780
RGGVRVGHRI IEINGQSVVA TPHEKIVHIL SNAVGEIHMK TMPAAMYRLL TAQEQPVYI 840
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport

Interpro

IPR030530--Apba1
IPR001478--PDZ
IPR011993--PH/PTB_dom
IPR006020--PTB/PI_dom

PROSITE

PS50106--PDZ
PS01179--PID

Pfam

PF00595--PDZ
PF00640--PID

Gene Ontology

GO:0043197--C:dendritic spine
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0008021--C:synaptic vesicle
GO:0001540--F:beta-amyloid binding
GO:0030165--F:PDZ domain binding
GO:0005546--F:phosphatidylinositol-4,5-bisphosphate binding
GO:0032403--F:protein complex binding
GO:0006461--P:protein complex assembly
GO:0015031--P:protein transport
GO:0016079--P:synaptic vesicle exocytosis