dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001215
Uniprot Accession O35412; SI1L1_RAT;
Genbank Protein ID NP_647546.1;
Genbank Nucleotide ID NM_139330.1;
Protein Name Signal-induced proliferation-associated 1-like protein 1
Protein Synonyms/Alias
Gene Name Sipa1l1
Gene Synonyms/Alias Spa1;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis.
Phosphorylation Sites
 dbPAF PTMs: 32 (View all)
PositionPeptidesSourceReferences ( PMIDs )
114ESLSSKGSPVSQGSScurated21630457
117SSKGSPVSQGSSVSLcurated21630457
120GSPVSQGSSVSLNSNcurated21630457
162MPEAYPSSPRKALRRPhosphoSitePlus22135298
255ITGGGKGSGFSLDVIcurated23984901
286EKPLKRRSKSETGDSdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated16641100; 16381945; 23193290; 22135298; 19366988; 22817900
288PLKRRSKSETGDSSIcurated23984901
559LEDAIPSTAKHSTARcurated23712012
563IPSTAKHSTARGLPLcurated23712012
1153RAANIPRSISSDGRPcurated23984901
1155ANIPRSISSDGRPLEcurated23712012; 21630457
1156NIPRSISSDGRPLERcurated23712012; 21630457
1169ERRLSPGSDIYVTVScurated23984901
1193RNSPSNLSSSSETGSdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated16641100; 16381945; 23193290; 22135298; 19366988; 22817900
1196PSNLSSSSETGSGGGdbPTM 3.0;PhosphoSitePlus;SysPTM 2.0;curated16641100; 16381945; 23193290; 22135298; 19366988; 22817900
1220GFGVSRRSPASIDRQPhosphoSitePlus;curated22135298; 23712012; 21630457
1288QDPVVHLSPNKQGHSPhosphoSitePlus;UniProt22135298; 22673903
1344LQGTSADSGIDTASYdbPTM 3.0;PhosphoSitePlus18723513; 16381945; 23193290; 22135298
1348SADSGIDTASYGLSHdbPTM 3.0;PhosphoSitePlus18723513; 16381945; 23193290; 22135298
1367SLGASTSSPRSGPGKdbPTM 3.0;PhosphoSitePlus;curated18498738; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MTSLKRSQTE RPVTADRASV VSTDGTPKVH TDDFYMRRFR SQNGSLGSSV MAAVGPPRSE 60
GPHHITSTPG VPKMGVRARI ADWPPRKENV KESSRSSQEI ETSSCLESLS SKGSPVSQGS 120
SVSLNSNDSA MLKSIQNTLK NKTGPAESMD SRFLMPEAYP SSPRKALRRI RQRSNSDITI 180
SELDVDSFDE CISPTYKSGP SLHREYGSTS SIDKQGTSGE SFFGLLKGYK DDRADRGPTP 240
TKLSDFLITG GGKGSGFSLD VIDGPISQRE NLRLFKEREK PLKRRSKSET GDSSIFRKLR 300
NAKGEELGKS SDLEDNRSED SVRPWTCPKC FAHYDVQSIL FDLNEAIMNR HNVIKRRNTT 360
TGASAAAVAS LVSGPLSHST SFSSPMGSTE DFNSKGSLGM DQGDDKSNEL VMSCPYFRNE 420
IGGEGERKIS LSKSNSGSFS GCESTSFESA LSSHCTNAGV AVLEVPKESL MLHLDRVRRY 480
TVEHVDLGAY YYRKCFYQKE HWNYFGADEN LGPVAVSIRR EKPEDMKENG SPYNYRIIFR 540
TSELMTLRGS VLEDAIPSTA KHSTARGLPL KEVLEHVIPE LNVQCLRLAF NTPKVTEQLM 600
KLDEQGLNYQ QKVGIMYCKA GQSTEEEMYN TPKVTEQFMK LDEQGLNYQQ KVGIMYCKAG 660
QSTEEEMYNN ESAGPAFEEF LQLLGERVRL KGFEKYRAQL DTKTDSTGTH SLYTTYKDYE 720
IMFHVSTMLP YTPNNKQQLL RKRHIGNDIV TIVFQEPGAQ PFSPKNIRSH FQHVFVIVRA 780
HNPCTESVCY SVAVTRSRDV PSFGPPIPKG VTFPKSNVFR DFLLAKVINA ENAAHKSEKF 840
RAMATRTRQE YLKDLAEKNV TNTPIDPSGK FPFISLASKK KEKSKPYPGA ELSSMGAIVW 900
AVRAKDYNKA MEFDCLLGIS NEFIVLIEQE TKSVVFNCSC RDVIGWTSSD SSLKIFYERG 960
ECISVESFMS SEDIKEIVKR LQFVSKGCES VEMTLRRNGL GQLGFHVNYE GIVADVEPYG 1020
YAWQAGLKQG SRLVEICKVA VATLSHEQMI DLLRTSVTVK VVIIPPHDDC TPRRSCSETY 1080
RMPVMEYKMN EGVSYEYKFP FRSNNKWQRN AGKGAHSPQV PLQLQSPMIS RVNAGKGDGK 1140
MPLPERAANI PRSISSDGRP LERRLSPGSD IYVTVSSMAL ARSQCRNSPS NLSSSSETGS 1200
GGGTYRQKSM PEGFGVSRRS PASIDRQNTQ SDIGGSGKST PSWQRSEDSL ADQMEPTCHL 1260
PAVSKVLPAF RESPSGRLMR QDPVVHLSPN KQGHSDSHYS SHSSSNTLSS NASSAHSDEK 1320
WYDGDRTESD LNSYNYLQGT SADSGIDTAS YGLSHGSTAS LGASTSSPRS GPGKEKVAPL 1380
WHSSSEVLSL ADRTLETEGH GMDRKTESSL SLDIHSKSQG GSSPLTRENS TFSINDATSH 1440
TSTMSSRHSA SPVVFSSARS SPKEELHPTT SSQLAPSFSS SSSSSSGPRT FYPRQGATSK 1500
YLIGWKKPEG TINSVGFMDT RKRHQSDGNE IAHTRLRAST RDLRASPKPT SKSTIEEDLK 1560
KLIDLESPTP ESQKNFKFHG LSSPQSPFPS TPTSRRALHR TLSDESIYSS QREHFFTSRA 1620
SLLDQALPND VFFSSTYPSL PKSLPLRRPS YTLGMKSLHG EFFASDSSLT DIQETRRQPI 1680
PDPGLMPLPD TASDLDWSNL VDAAKAYEVQ RASFFAASDE NHRPLSAASN SDQLEEQALV 1740
QMKSYSSSKD SSPTLASKVD QLEGMLKMLR EDLKKEKEDK AHLQAEVEHL REDNLRLQEE 1800
SQNASDKLKK FTEWVFNTID MS 1823
Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0343--GTPase activation
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0770--Synapse
KW-0771--Synaptosome
KW-0832--Ubl conjugation
Interpro

IPR001478--PDZ
IPR000331--Rap_GAP_dom
IPR021818--SIPA1L_C
PROSITE

PS50106--PDZ
PS50085--RAPGAP
Pfam

PF02145--Rap_GAP
PF11881--SPAR_C
Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0043197--C:dendritic spine
GO:0043025--C:neuronal cell body
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0043234--C:protein complex
GO:0051015--F:actin filament binding
GO:0005096--F:GTPase activator activity
GO:0032403--F:protein complex binding
GO:0019901--F:protein kinase binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0031532--P:actin cytoskeleton reorganization
GO:0090630--P:activation of GTPase activity
GO:0048013--P:ephrin receptor signaling pathway
GO:0050770--P:regulation of axonogenesis
GO:0048814--P:regulation of dendrite morphogenesis
GO:0061001--P:regulation of dendritic spine morphogenesis
GO:0043087--P:regulation of GTPase activity
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0048167--P:regulation of synaptic plasticity