| Tag |
Content |
| dbPAF ID |
dbPAF-0001210 |
| Uniprot Accession |
O35397; CASP6_RAT;
|
| Genbank Protein ID |
|
| Genbank Nucleotide ID |
|
| Protein Name |
Caspase-6 |
| Protein Synonyms/Alias |
|
| Gene Name |
Casp6 |
| Gene Synonyms/Alias |
Mch2; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death (By similarity).Functional Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 62 | DNPTRRFSELGFEVK | curated | 23984901 |
|
Sequence
(Fasta) | MTETDGFYRS REVLDPAEQY KMDHKRRGTA LIFNHERFFW HLALPERRGT NADRDNPTRR 60
FSELGFEVKC FNDLRAEELL LKIHEVSTSS HVDADCFLCV FLSHGEGNHI YAYDAKIEIQ 120
TLTGLFKGDK CQSLVGKPKI FIIQACRGSQ HDVPLVPLDV VDHQTDKLDD NVTQVDAASV 180
YTLPAGADFL MCYSVAEGYY SHRETVNGSW YIQDLSEMLA RHGSSLEFTE LLTLVNRKVS 240
QRRVDFCKDP GAIGKKQVPC FASMLTKKLH FCPKPSK
278Fasta Sequence
>O35397|Casp6|Rattus norvegicus(Rat)
MTETDGFYRSREVLDPAEQYKMDHKRRGTALIFNHERFFWHLALPERRGTNADRDNPTRRFSELGFEVKCFNDLRAEELLLKIHEVSTSSHVDADCFLCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRGSQHDVPLVPLDVVDHQTDKLDDNVTQVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLSEMLARHGSSLEFTELLTLVNRKVSQRRVDFCKDPGAIGKKQVPCFASMLTKKLHFCPKPSK
|
| Keyword |
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0865--Zymogen
|
| Interpro |
IPR029030--Caspase-like_dom
IPR011600--Pept_C14_caspase
IPR001309--Pept_C14_ICE_p20
IPR016129--Pept_C14_ICE_p20_AS
IPR002138--Pept_C14_p10
IPR015917--Pept_C14A_p45_core
|
| PROSITE |
PS01122--CASPASE_CYS
PS01121--CASPASE_HIS
PS50207--CASPASE_P10
PS50208--CASPASE_P20
|
| Pfam |
PF00656--Peptidase_C14
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0097200--F:cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0004175--F:endopeptidase activity
GO:0002525--P:acute inflammatory response to non-antigenic stimulus
GO:0006915--P:apoptotic process
GO:0097194--P:execution phase of apoptosis
GO:0002088--P:lens development in camera-type eye
GO:0043065--P:positive regulation of apoptotic process
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0046670--P:positive regulation of retinal cell programmed cell death
GO:0034097--P:response to cytokine
GO:0032355--P:response to estradiol
GO:0010332--P:response to gamma radiation
GO:0009749--P:response to glucose
GO:0009408--P:response to heat
GO:0042542--P:response to hydrogen peroxide
GO:0010039--P:response to iron ion
GO:0010038--P:response to metal ion
GO:0010033--P:response to organic substance
GO:0010243--P:response to organonitrogen compound
GO:0033574--P:response to testosterone
|
