| Tag |
Content |
| dbPAF ID |
dbPAF-0001185 |
| Uniprot Accession |
O35303; DNM1L_RAT; O35318; O35319; O35320; O35321; O35322; O35323; Q5U2W1; Q792T7; Q9R234; Q9R277;
|
| Genbank Protein ID |
NP_446107.2; XP_006248778.1; XP_006248780.1; XP_006248785.1; XP_008767063.1; XP_008767064.1; XP_008767065.1;
|
| Genbank Nucleotide ID |
NM_053655.3; XM_006248716.2; XM_006248718.2; XM_006248723.2; XM_008768841.1; XM_008768842.1; XM_008768843.1;
|
| Protein Name |
Dynamin-1-like protein |
| Protein Synonyms/Alias |
Dynamin-like protein; |
| Gene Name |
Dnm1l |
| Gene Synonyms/Alias |
Dlp1; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.Functional Description
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution. |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGVVTR 60
RPLILQLVHV SPEDKRKTTG EENDPATWKN SRHLSKGVEA EEWGKFLHTK NKLYTDFDEI 120
RQEIENETER ISGNNKGVSP EPIHLKVFSP NVVNLTLVDL PGMTKVPVGD QPKDIELQIR 180
ELILRFISNP NSIILAVTAA NTDMATSEAL KISREVDPDG RRTLAVITKL DLMDAGTDAM 240
DVLMGRVIPV KLGIIGVVNR SQLDINNKKS VTDSIRDEYA FLQKKYPSLA NRNGTKYLAR 300
TLNRLLMHHI RDCLPELKTR INVLAAQYQS LLNSYGEPVD DKSATLLQLI TKFATEYCNT 360
IEGTAKYIET SELCGGARIC YIFHETFGRT LESVDPLGGL NTIDILTAIR NATGPRPALF 420
VPEVSFELLV KRQIKRLEEP SLRCVELVHE EMQRIIQHCS NYSTQELLRF PKLHDAIVEV 480
VTCLLRKRLP VTNEMVHNLV AIELAYINTK HPDFADACGL MNNNIEEQRR NRLARELPSA 540
VSRDKSSKVP SALAPASQEP SPAASAEADG KLIQDNRRET KNVASAGGGI GDGGRIGDGG 600
QEPTTGNWRG MLKTSKAEEL LAEEKSKPIP IMPASPQKGH AVNLLDVPVP VARKLSAREQ 660
RDCEVIERLI KSYFLIVRKN IQDSVPKAVM HFLVNHVKDT LQSELVGQLY KSSLLDDLLT 720
ESEDMAQRRK EAADMLKALQ GASQIIAEIR ETHLW
756Fasta Sequence
>O35303|Dnm1l|Rattus norvegicus(Rat)
MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENDPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDNRRETKNVASAGGGIGDGGRIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW
|
| Keyword |
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0168--Coated pit
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0254--Endocytosis
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0342--GTP-binding
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-1210--Necrosis
KW-0547--Nucleotide-binding
KW-0576--Peroxisome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0702--S-nitrosylation
KW-0770--Synapse
KW-0832--Ubl conjugation
|
| Interpro |
IPR030556--DNM1L
IPR000375--Dynamin_central
IPR001401--Dynamin_GTPase
IPR019762--Dynamin_GTPase_CS
IPR022812--Dynamin_SF
IPR030381--G_DYNAMIN_dom
IPR003130--GED
IPR020850--GED_dom
IPR027417--P-loop_NTPase
|
| PROSITE |
PS00410--G_DYNAMIN_1
PS51718--G_DYNAMIN_2
PS51388--GED
|
| Pfam |
PF01031--Dynamin_M
PF00350--Dynamin_N
PF02212--GED
|
| Gene Ontology |
GO:0005903--C:brush border
GO:0030054--C:cell junction
GO:0005905--C:coated pit
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005874--C:microtubule
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0048471--C:perinuclear region of cytoplasm
GO:0005777--C:peroxisome
GO:0030672--C:synaptic vesicle membrane
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0008289--F:lipid binding
GO:0042803--F:protein homodimerization activity
GO:0003374--P:dynamin polymerization involved in mitochondrial fission
GO:0006897--P:endocytosis
GO:0060047--P:heart contraction
GO:0061025--P:membrane fusion
GO:0000266--P:mitochondrial fission
GO:0043653--P:mitochondrial fragmentation involved in apoptotic process
GO:0090149--P:mitochondrial membrane fission
GO:0070584--P:mitochondrion morphogenesis
GO:0070266--P:necroptotic process
GO:0016559--P:peroxisome fission
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0090141--P:positive regulation of mitochondrial fission
GO:0050714--P:positive regulation of protein secretion
GO:0090200--P:positive regulation of release of cytochrome c from mitochondria
GO:0051289--P:protein homotetramerization
GO:0070585--P:protein localization to mitochondrion
GO:1903578--P:regulation of ATP metabolic process
GO:1903146--P:regulation of mitophagy
GO:1900063--P:regulation of peroxisome organization
GO:0032459--P:regulation of protein oligomerization
GO:0001836--P:release of cytochrome c from mitochondria
|
