Tag |
Content |
dbPAF ID |
dbPAF-0001175 |
Uniprot Accession |
O35260; NACC1_RAT; |
Genbank Protein ID |
NP_599240.1; XP_008770568.1; |
Genbank Nucleotide ID |
NM_134413.2; XM_008772346.1; |
Protein Name |
Nucleus accumbens-associated protein 1 |
Protein Synonyms/Alias |
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Gene Name |
Nacc1 |
Gene Synonyms/Alias |
Btbd14b;Nac1; |
Organism |
Rattus norvegicus(Rat) |
NCBI Taxa ID |
10116 |
Functional Description (View all) |
Functions as a transcriptional repressor. Isoform 1 is a stronger transcriptional repressor than isoform 2. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.Functional Description
Functions as a transcriptional repressor. Isoform 1 is a stronger transcriptional repressor than isoform 2. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
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Phosphorylation Sites
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dbPAF PTMs: 1 |
Sequence (Fasta) | MAQTLQMEIP NFGNSILECL NEQRLQGLYC DVSVVVKGHA FKAHRAVLAA SSSYFRDLFN 60 SSRSAVVELP AAVQPQSFQQ ILTFCYTGRL SMNMGDQFLL IYTAGFLQIQ EIMEKGTEFF 120 LKVSSPSCDS QGLHPEEAPS SEPQSPVAQI LGWPACSTPL PLVSRVKTEQ ELDSVQCTPM 180 AKRLWDSSQK EAGGSGGNNG SRKMAKFSTP DLAPNRMPQP VSVATATAAV AVVAVGGCVS 240 GPSMSERTSP GTSSAYTSDS PSSYHNEEDE EEDAGEEGTD EQYRQICNMY TMYSMLNVGQ 300 TVEKVEALPE QVVLESHSRI RVRQDLASLP AELINQIGNR CHPKLYDEGD PSEKLELVTG 360 TNVYITRAQL MNCHVSAGTR HKVLLRRLLA SFFDRNTLAN SCGTGIRSST NDPRRKPLDS 420 RVLHAVKYYC QNFAPNFKES EMNAIAADMC TNARRVVRKS WLPKTKPLHL VEGDNYSSFI 480 SDTGKIEPDM MSMEHSFETA SHDGEAGPSA EVLQ
515Fasta Sequence
>O35260|Nacc1|Rattus norvegicus(Rat) MAQTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILTFCYTGRLSMNMGDQFLLIYTAGFLQIQEIMEKGTEFFLKVSSPSCDSQGLHPEEAPSSEPQSPVAQILGWPACSTPLPLVSRVKTEQELDSVQCTPMAKRLWDSSQKEAGGSGGNNGSRKMAKFSTPDLAPNRMPQPVSVATATAAVAVVAVGGCVSGPSMSERTSPGTSSAYTSDSPSSYHNEEDEEEDAGEEGTDEQYRQICNMYTMYSMLNVGQTVEKVEALPEQVVLESHSRIRVRQDLASLPAELINQIGNRCHPKLYDEGDPSEKLELVTGTNVYITRAQLMNCHVSAGTRHKVLLRRLLASFFDRNTLANSCGTGIRSSTNDPRRKPLDSRVLHAVKYYCQNFAPNFKESEMNAIAADMCTNARRVVRKSWLPKTKPLHLVEGDNYSSFISDTGKIEPDMMSMEHSFETASHDGEAGPSAEVLQ
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Keyword |
KW-0025--Alternative splicing KW-0181--Complete proteome KW-0963--Cytoplasm KW-1017--Isopeptide bond KW-0539--Nucleus KW-0597--Phosphoprotein KW-1185--Reference proteome KW-0678--Repressor KW-0804--Transcription KW-0805--Transcription regulation KW-0832--Ubl conjugation
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Interpro |
IPR018379--BEN_domain IPR000210--BTB/POZ_dom IPR011333--POZ_dom
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PROSITE |
PS51457--BEN PS50097--BTB
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Pfam |
PF10523--BEN PF00651--BTB
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Gene Ontology |
GO:0005737--C:cytoplasm GO:0016604--C:nuclear body GO:0005634--C:nucleus GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter GO:0045892--P:negative regulation of transcription, DNA-templated GO:0008284--P:positive regulation of cell proliferation GO:0051260--P:protein homooligomerization GO:0006351--P:transcription, DNA-templated
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