| Tag |
Content |
| dbPAF ID |
dbPAF-0001175 |
| Uniprot Accession |
O35260; NACC1_RAT;
|
| Genbank Protein ID |
NP_599240.1; XP_008770568.1;
|
| Genbank Nucleotide ID |
NM_134413.2; XM_008772346.1;
|
| Protein Name |
Nucleus accumbens-associated protein 1 |
| Protein Synonyms/Alias |
|
| Gene Name |
Nacc1 |
| Gene Synonyms/Alias |
Btbd14b;Nac1; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Functions as a transcriptional repressor. Isoform 1 is a stronger transcriptional repressor than isoform 2. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.Functional Description
Functions as a transcriptional repressor. Isoform 1 is a stronger transcriptional repressor than isoform 2. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MAQTLQMEIP NFGNSILECL NEQRLQGLYC DVSVVVKGHA FKAHRAVLAA SSSYFRDLFN 60
SSRSAVVELP AAVQPQSFQQ ILTFCYTGRL SMNMGDQFLL IYTAGFLQIQ EIMEKGTEFF 120
LKVSSPSCDS QGLHPEEAPS SEPQSPVAQI LGWPACSTPL PLVSRVKTEQ ELDSVQCTPM 180
AKRLWDSSQK EAGGSGGNNG SRKMAKFSTP DLAPNRMPQP VSVATATAAV AVVAVGGCVS 240
GPSMSERTSP GTSSAYTSDS PSSYHNEEDE EEDAGEEGTD EQYRQICNMY TMYSMLNVGQ 300
TVEKVEALPE QVVLESHSRI RVRQDLASLP AELINQIGNR CHPKLYDEGD PSEKLELVTG 360
TNVYITRAQL MNCHVSAGTR HKVLLRRLLA SFFDRNTLAN SCGTGIRSST NDPRRKPLDS 420
RVLHAVKYYC QNFAPNFKES EMNAIAADMC TNARRVVRKS WLPKTKPLHL VEGDNYSSFI 480
SDTGKIEPDM MSMEHSFETA SHDGEAGPSA EVLQ
515Fasta Sequence
>O35260|Nacc1|Rattus norvegicus(Rat)
MAQTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILTFCYTGRLSMNMGDQFLLIYTAGFLQIQEIMEKGTEFFLKVSSPSCDSQGLHPEEAPSSEPQSPVAQILGWPACSTPLPLVSRVKTEQELDSVQCTPMAKRLWDSSQKEAGGSGGNNGSRKMAKFSTPDLAPNRMPQPVSVATATAAVAVVAVGGCVSGPSMSERTSPGTSSAYTSDSPSSYHNEEDEEEDAGEEGTDEQYRQICNMYTMYSMLNVGQTVEKVEALPEQVVLESHSRIRVRQDLASLPAELINQIGNRCHPKLYDEGDPSEKLELVTGTNVYITRAQLMNCHVSAGTRHKVLLRRLLASFFDRNTLANSCGTGIRSSTNDPRRKPLDSRVLHAVKYYCQNFAPNFKESEMNAIAADMCTNARRVVRKSWLPKTKPLHLVEGDNYSSFISDTGKIEPDMMSMEHSFETASHDGEAGPSAEVLQ
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
|
| Interpro |
IPR018379--BEN_domain
IPR000210--BTB/POZ_dom
IPR011333--POZ_dom
|
| PROSITE |
PS51457--BEN
PS50097--BTB
|
| Pfam |
PF10523--BEN
PF00651--BTB
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0008284--P:positive regulation of cell proliferation
GO:0051260--P:protein homooligomerization
GO:0006351--P:transcription, DNA-templated
|
