| Tag |
Content |
| dbPAF ID |
dbPAF-0001170 |
| Uniprot Accession |
O35244; PRDX6_RAT;
|
| Genbank Protein ID |
NP_446028.1;
|
| Genbank Nucleotide ID |
NM_053576.2;
|
| Protein Name |
Peroxiredoxin-6 |
| Protein Synonyms/Alias |
1-Cys peroxiredoxin;1-Cys PRX;Acidic calcium-independent phospholipase A2;aiPLA2; |
| Gene Name |
Prdx6 |
| Gene Synonyms/Alias |
Aipla2;Aop2;Tsa; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.Functional Description
Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MPGGLLLGDE APNFEANTTI GHIRFHDFLG DSWGILFSHP RDFTPVCTTE LGRAAKLAPE 60
FAKRNVKLIA LSIDSVEDHF AWSKDINAYN GAAPTEKLPF PIIDDKDRDL AILLGMLDPA 120
EKDEKGMPVT ARVVFIFGPD KKLKLSILYP ATTGRNFDEI LRVVDSLQLT ASNPVATPVD 180
WKKGESVMVL PTLPEEEAKQ LFPKGVFTKE LPSGKKYLRY TPQP
225Fasta Sequence
>O35244|Prdx6|Rattus norvegicus(Rat)
MPGGLLLGDEAPNFEANTTIGHIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHFAWSKDINAYNGAAPTEKLPFPIIDDKDRDLAILLGMLDPAEKDEKGMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEILRVVDSLQLTASNPVATPVDWKKGESVMVLPTLPEEEAKQLFPKGVFTKELPSGKKYLRYTPQP
|
| Keyword |
KW-0007--Acetylation
KW-0049--Antioxidant
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-0458--Lysosome
KW-0511--Multifunctional enzyme
KW-0560--Oxidoreductase
KW-0575--Peroxidase
KW-0597--Phosphoprotein
KW-0676--Redox-active center
KW-1185--Reference proteome
|
| Interpro |
IPR000866--AhpC/TSA
IPR024706--Peroxiredoxin_AhpC-typ
IPR019479--Peroxiredoxin_C
IPR012336--Thioredoxin-like_fold
|
| PROSITE |
PS51352--THIOREDOXIN_2
|
| Pfam |
PF10417--1-cysPrx_C
PF00578--AhpC-TSA
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0016023--C:cytoplasmic membrane-bounded vesicle
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0005764--C:lysosome
GO:0016020--C:membrane
GO:0004602--F:glutathione peroxidase activity
GO:0051920--F:peroxiredoxin activity
GO:0004623--F:phospholipase A2 activity
GO:0042744--P:hydrogen peroxide catabolic process
GO:0009395--P:phospholipid catabolic process
GO:0006979--P:response to oxidative stress
|
