| Tag |
Content |
| dbPAF ID |
dbPAF-0001168 |
| Uniprot Accession |
O35240; ASIC3_RAT;
|
| Genbank Protein ID |
NP_775158.1;
|
| Genbank Nucleotide ID |
NM_173135.1;
|
| Protein Name |
Acid-sensing ion channel 3 |
| Protein Synonyms/Alias |
|
| Gene Name |
Asic3 |
| Gene Synonyms/Alias |
Accn3;Drasic; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.Functional Description
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MKPRSGLEEA QRRQASDIRV FASSCTMHGL GHIFGPGGLT LRRGLWATAV LLSLAAFLYQ 60
VAERVRYYGE FHHKTTLDER ESHQLTFPAV TLCNINPLRR SRLTPNDLHW AGTALLGLDP 120
AEHAAYLRAL GQPPAPPGFM PSPTFDMAQL YARAGHSLED MLLDCRYRGQ PCGPENFTVI 180
FTRMGQCYTF NSGAHGAELL TTPKGGAGNG LEIMLDVQQE EYLPIWKDME ETPFEVGIRV 240
QIHSQDEPPA IDQLGFGAAP GHQTFVSCQQ QQLSFLPPPW GDCNTASLDP DDFDPEPSDP 300
LGSPRPRPSP PYSLIGCRLA CESRYVARKC GCRMMHMPGN SPVCSPQQYK DCASPALDAM 360
LRKDTCVCPN PCATTRYAKE LSMVRIPSRA SARYLARKYN RSESYITENV LVLDIFFEAL 420
NYEAVEQKAA YEVSELLGDI GGQMGLFIGA SLLTILEILD YLCEVFQDRV LGYFWNRRSA 480
QKRSGNTLLQ EELNGHRTHV PHLSLGPRPP TTPCAVTKTL SASHRTCYLV TRL
534Fasta Sequence
>O35240|Asic3|Rattus norvegicus(Rat)
MKPRSGLEEAQRRQASDIRVFASSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQVAERVRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYLRALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQPCGPENFTVIFTRMGQCYTFNSGAHGAELLTTPKGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHSQDEPPAIDQLGFGAAPGHQTFVSCQQQQLSFLPPPWGDCNTASLDPDDFDPEPSDPLGSPRPRPSPPYSLIGCRLACESRYVARKCGCRMMHMPGNSPVCSPQQYKDCASPALDAMLRKDTCVCPNPCATTRYAKELSMVRIPSRASARYLARKYNRSESYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFIGASLLTILEILDYLCEVFQDRVLGYFWNRRSAQKRSGNTLLQEELNGHRTHVPHLSLGPRPPTTPCAVTKTLSASHRTCYLVTRL
|
| Keyword |
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0407--Ion channel
KW-0406--Ion transport
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0915--Sodium
KW-0894--Sodium channel
KW-0739--Sodium transport
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
|
| Interpro |
IPR004724--ENaC
IPR001873--Na+channel_ASC
IPR020903--Na+channel_ASC_CS
|
| PROSITE |
PS01206--ASC
|
| Pfam |
PF00858--ASC
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005887--C:integral component of plasma membrane
GO:0042931--F:enterobactin transporter activity
GO:0015280--F:ligand-gated sodium channel activity
GO:0030165--F:PDZ domain binding
GO:0050968--P:detection of chemical stimulus involved in sensory perception of pain
GO:0050966--P:detection of mechanical stimulus involved in sensory perception of pain
GO:0050965--P:detection of temperature stimulus involved in sensory perception of pain
GO:0010447--P:response to acidic pH
GO:0009408--P:response to heat
GO:0035725--P:sodium ion transmembrane transport
GO:0006814--P:sodium ion transport
|
