| Tag |
Content |
| dbPAF ID |
dbPAF-0001157 |
| Uniprot Accession |
O35186; CATK_RAT;
|
| Genbank Protein ID |
NP_113748.1;
|
| Genbank Nucleotide ID |
NM_031560.2;
|
| Protein Name |
Cathepsin K |
| Protein Synonyms/Alias |
|
| Gene Name |
Ctsk |
| Gene Synonyms/Alias |
|
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity).Functional Description
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MWVFKFLLLP VVSFALSPEE TLDTQWELWK KTHGKQYNSK VDEISRRLIW EKNLKKISVH 60
NLEASLGAHT YELAMNHLGD MTSEEVVQKM TGLRVPPSRS FSNDTLYTPE WEGRVPDSID 120
YRKKGYVTPV KNQGQCGSCW AFSSAGALEG QLKKKTGKLL ALSPQNLVDC VSENYGCGGG 180
YMTTAFQYVQ QNGGIDSEDA YPYVGQDESC MYNATAKAAK CRGYREIPVG NEKALKRAVA 240
RVGPVSVSID ASLTSFQFYS RGVYYDENCD RDNVNHAVLV VGYGTQKGNK YWIIKNSWGE 300
SWGNKGYVLL ARNKNNACGI TNLASFPKM
Fasta Sequence
>O35186|Ctsk|Rattus norvegicus(Rat)
MWVFKFLLLPVVSFALSPEETLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVHNLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFPKM
|
| Keyword |
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0378--Hydrolase
KW-0458--Lysosome
KW-0645--Protease
KW-1185--Reference proteome
KW-0732--Signal
KW-0788--Thiol protease
KW-0865--Zymogen
|
| Interpro |
IPR025661--Pept_asp_AS
IPR000169--Pept_cys_AS
IPR025660--Pept_his_AS
IPR013128--Peptidase_C1A
IPR000668--Peptidase_C1A_C
IPR015644--Peptidase_C1A_cathepsin-K
IPR013201--Prot_inhib_I29
|
| PROSITE |
PS00640--THIOL_PROTEASE_ASN
PS00139--THIOL_PROTEASE_CYS
PS00639--THIOL_PROTEASE_HIS
|
| Pfam |
PF08246--Inhibitor_I29
PF00112--Peptidase_C1
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005615--C:extracellular space
GO:0005764--C:lysosome
GO:0004197--F:cysteine-type endopeptidase activity
GO:0008234--F:cysteine-type peptidase activity
GO:0045453--P:bone resorption
GO:0030574--P:collagen catabolic process
GO:0001957--P:intramembranous ossification
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0006508--P:proteolysis
GO:0051603--P:proteolysis involved in cellular protein catabolic process
GO:1903146--P:regulation of mitophagy
|
