Tag |
Content |
dbPAF ID |
dbPAF-0001147 |
Uniprot Accession |
O35147; BAD_RAT; O70256; Q9JHX1; |
Genbank Protein ID |
NP_073189.1; XP_006230958.1; |
Genbank Nucleotide ID |
NM_022698.1; XM_006230896.2; |
Protein Name |
Bcl2-associated agonist of cell death |
Protein Synonyms/Alias |
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Gene Name |
Bad |
Gene Synonyms/Alias |
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Organism |
Rattus norvegicus(Rat) |
NCBI Taxa ID |
10116 |
Functional Description (View all) |
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.Functional Description
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
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Phosphorylation Sites
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dbPAF PTMs: 11 |
Sequence (Fasta) | MGTPKQPSLA PAHALGLRKS DPGIRSLGSD AGGRRWRPAA QSMFQIPEFE PSEQEDASTT 60 DRGLGPSLTE DQPGPYLAPG LLGSIVQQQP GQAANNSHHG GAGTMETRSR HSSYPAGTEE 120 DEGMEEELSP FRGRSRSAPP NLWAAQRYGR ELRRMSDEFE GSFKGLPRPK SAGTATQMRQ 180 SASWTRIIQS WWDRNLGKGG STPSQ
206Fasta Sequence
>O35147|Bad|Rattus norvegicus(Rat) MGTPKQPSLAPAHALGLRKSDPGIRSLGSDAGGRRWRPAAQSMFQIPEFEPSEQEDASTTDRGLGPSLTEDQPGPYLAPGLLGSIVQQQPGQAANNSHHGGAGTMETRSRHSSYPAGTEEDEGMEEELSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFEGSFKGLPRPKSAGTATQMRQSASWTRIIQSWWDRNLGKGGSTPSQ
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Keyword |
KW-0025--Alternative splicing KW-0053--Apoptosis KW-0181--Complete proteome KW-0963--Cytoplasm KW-0472--Membrane KW-0488--Methylation KW-0496--Mitochondrion KW-1000--Mitochondrion outer membrane KW-0597--Phosphoprotein KW-1185--Reference proteome
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Interpro |
IPR018868--Bcl-2_BAD
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PROSITE |
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Pfam |
PF10514--Bcl-2_BAD
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Gene Ontology |
GO:0005829--C:cytosol GO:0005741--C:mitochondrial outer membrane GO:0005739--C:mitochondrion GO:0071889--F:14-3-3 protein binding GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008289--F:lipid binding GO:0005543--F:phospholipid binding GO:0043422--F:protein kinase B binding GO:0030346--F:protein phosphatase 2B binding GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0046031--P:ADP metabolic process GO:0046034--P:ATP metabolic process GO:0060154--P:cellular process regulating host cell cycle in response to virus GO:0071247--P:cellular response to chromate GO:0071456--P:cellular response to hypoxia GO:0071396--P:cellular response to lipid GO:0071260--P:cellular response to mechanical stimulus GO:0071316--P:cellular response to nicotine GO:0021987--P:cerebral cortex development GO:0019221--P:cytokine-mediated signaling pathway GO:0097192--P:extrinsic apoptotic signaling pathway in absence of ligand GO:0008625--P:extrinsic apoptotic signaling pathway via death domain receptors GO:0006007--P:glucose catabolic process GO:0042593--P:glucose homeostasis GO:0097193--P:intrinsic apoptotic signaling pathway GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage GO:0045918--P:negative regulation of cytolysis GO:0046931--P:pore complex assembly GO:0060139--P:positive regulation of apoptotic process by virus GO:0045579--P:positive regulation of B cell differentiation GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0050679--P:positive regulation of epithelial cell proliferation GO:0033133--P:positive regulation of glucokinase activity GO:0032024--P:positive regulation of insulin secretion GO:0035774--P:positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0010918--P:positive regulation of mitochondrial membrane potential GO:1901216--P:positive regulation of neuron death GO:0090200--P:positive regulation of release of cytochrome c from mitochondria GO:0045582--P:positive regulation of T cell differentiation GO:2000078--P:positive regulation of type B pancreatic cell development GO:0046902--P:regulation of mitochondrial membrane permeability GO:0001836--P:release of cytochrome c from mitochondria GO:0043200--P:response to amino acid GO:0051592--P:response to calcium ion GO:0042493--P:response to drug GO:0032355--P:response to estradiol GO:0045471--P:response to ethanol GO:0051384--P:response to glucocorticoid GO:0009749--P:response to glucose GO:0009725--P:response to hormone GO:0042542--P:response to hydrogen peroxide GO:0001666--P:response to hypoxia GO:0034201--P:response to oleic acid GO:0014070--P:response to organic cyclic compound GO:0010033--P:response to organic substance GO:0032570--P:response to progesterone GO:0033574--P:response to testosterone GO:0007283--P:spermatogenesis GO:0019050--P:suppression by virus of host apoptotic process GO:0044342--P:type B pancreatic cell proliferation
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