dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001147
Uniprot Accession O35147; BAD_RAT; O70256; Q9JHX1;
Genbank Protein ID NP_073189.1; XP_006230958.1;
Genbank Nucleotide ID NM_022698.1; XM_006230896.2;
Protein Name Bcl2-associated agonist of cell death
Protein Synonyms/Alias
Gene Name Bad
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Phosphorylation Sites
dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
109AGTMETRSRHSSYPAcurated23984901
113ETRSRHSSYPAGTEEdbPTM 3.0;PhosphoSitePlus;UniProt;curated-; 16381945; 23193290; 11490019; 11493700; 11978789; 1201930
114TRSRHSSYPAGTEEDcurated25532521
118HSSYPAGTEEDEGMEdbPTM 3.0;PhosphoSitePlus;curated15234118; 16381945; 23193290; 22135298; 22817900
129EGMEEELSPFRGRSRdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated12049737; 16381945; 23193290; 22135298; 22817900
135LSPFRGRSRSAPPNLPhosphoSitePlus;UniProt;curated22135298; 22673903; 23984901
137PFRGRSRSAPPNLWAdbPTM 3.0;PhosphoSitePlus;curated-; 16381945; 23193290; 11027222; 11490019; 11493700; 1157178
156GRELRRMSDEFEGSFdbPTM 3.0;PhosphoSitePlus;UniProt;curated11978789; 12427737; 15036616; 16381945; 23193290; 22135298;
171KGLPRPKSAGTATQMcurated21630457
181TATQMRQSASWTRIIPhosphoSitePlus22135298
183TQMRQSASWTRIIQSPhosphoSitePlus22135298
Sequence
(Fasta)
MGTPKQPSLA PAHALGLRKS DPGIRSLGSD AGGRRWRPAA QSMFQIPEFE PSEQEDASTT 60
DRGLGPSLTE DQPGPYLAPG LLGSIVQQQP GQAANNSHHG GAGTMETRSR HSSYPAGTEE 120
DEGMEEELSP FRGRSRSAPP NLWAAQRYGR ELRRMSDEFE GSFKGLPRPK SAGTATQMRQ 180
SASWTRIIQS WWDRNLGKGG STPSQ 206
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0488--Methylation
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR018868--Bcl-2_BAD

PROSITE
Pfam

PF10514--Bcl-2_BAD

Gene Ontology

GO:0005829--C:cytosol
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0071889--F:14-3-3 protein binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008289--F:lipid binding
GO:0005543--F:phospholipid binding
GO:0043422--F:protein kinase B binding
GO:0030346--F:protein phosphatase 2B binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046031--P:ADP metabolic process
GO:0046034--P:ATP metabolic process
GO:0060154--P:cellular process regulating host cell cycle in response to virus
GO:0071247--P:cellular response to chromate
GO:0071456--P:cellular response to hypoxia
GO:0071396--P:cellular response to lipid
GO:0071260--P:cellular response to mechanical stimulus
GO:0071316--P:cellular response to nicotine
GO:0021987--P:cerebral cortex development
GO:0019221--P:cytokine-mediated signaling pathway
GO:0097192--P:extrinsic apoptotic signaling pathway in absence of ligand
GO:0008625--P:extrinsic apoptotic signaling pathway via death domain receptors
GO:0006007--P:glucose catabolic process
GO:0042593--P:glucose homeostasis
GO:0097193--P:intrinsic apoptotic signaling pathway
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0045918--P:negative regulation of cytolysis
GO:0046931--P:pore complex assembly
GO:0060139--P:positive regulation of apoptotic process by virus
GO:0045579--P:positive regulation of B cell differentiation
GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0033133--P:positive regulation of glucokinase activity
GO:0032024--P:positive regulation of insulin secretion
GO:0035774--P:positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0010918--P:positive regulation of mitochondrial membrane potential
GO:1901216--P:positive regulation of neuron death
GO:0090200--P:positive regulation of release of cytochrome c from mitochondria
GO:0045582--P:positive regulation of T cell differentiation
GO:2000078--P:positive regulation of type B pancreatic cell development
GO:0046902--P:regulation of mitochondrial membrane permeability
GO:0001836--P:release of cytochrome c from mitochondria
GO:0043200--P:response to amino acid
GO:0051592--P:response to calcium ion
GO:0042493--P:response to drug
GO:0032355--P:response to estradiol
GO:0045471--P:response to ethanol
GO:0051384--P:response to glucocorticoid
GO:0009749--P:response to glucose
GO:0009725--P:response to hormone
GO:0042542--P:response to hydrogen peroxide
GO:0001666--P:response to hypoxia
GO:0034201--P:response to oleic acid
GO:0014070--P:response to organic cyclic compound
GO:0010033--P:response to organic substance
GO:0032570--P:response to progesterone
GO:0033574--P:response to testosterone
GO:0007283--P:spermatogenesis
GO:0019050--P:suppression by virus of host apoptotic process
GO:0044342--P:type B pancreatic cell proliferation