dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0001144 |
| Uniprot Accession | O35142; COPB2_RAT; |
| Genbank Protein ID | NP_068533.1; |
| Genbank Nucleotide ID | NM_021765.1; |
| Protein Name | Coatomer subunit beta' |
| Protein Synonyms/Alias | Beta'-coat protein;Beta'-COP;p102; |
| Gene Name | Copb2 |
| Gene Synonyms/Alias | |
| Organism | Rattus norvegicus(Rat) |
| NCBI Taxa ID | 10116 |
| Functional Description (View all) |
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MPLRLDIKRK LTAMSDRVKS VDLHPTEPWM LASLYNGSVC VWNHETQTLV KTFEVCDLPV 60 RAAKFVARKN WVVTGADDMQ IRVFNYNTLE RVHMFEAHSD YIRCIAVHPT QPFILTSSDD 120 MLIKLWDWDK KWSCSQVFEG HTHYVMQIVI NPKDNNQFAS ASLDRTIKVW QLGSSSPNFT 180 LEGHEKGVNC IDYYSGGDKP YLISGADDRL VKIWDYQNKT CVQTPEGHAQ NVSCATFHPE 240 LPIIITGSED GTVRIWHSST YRLESTLNYG MERVWCVASL RGSNNVALGY DEGSIIVKLG 300 REEPAMSMDA NGKIIWAKHS EVQQANLKAM GDTEIKDGER LPLAVKDMGS CEIYPQTIQH 360 NPNGRFVVVC GDGEYIIYTA MALRNKSFGS AQEFAWAHDS SEYAIRESNS VVKIFKNFKE 420 KKSFKPDFGA ESIYGGFLLG VRSVNGLAFY DWENTELIRR IEIQPKHIFW SDSGELVCIA 480 TEESFFILKY LSEKVLAAQE THEGVTEDGI EDAFEVLGEI QEIVKTGLWV GDCFIYTSSV 540 NRLNYYVGGE IVTIAHLDRT MYLLGYIPKD NRLYLGDKEL NIVSYSLLVS VLEYQTAVMR 600 RDFSMADKVL PTIPKEQRTR VAHFLEKQGF KQQALTVSTD PEHRFELALQ LGELKIAYQL 660 AVEAESEQKW KQLAELAISK CQFSLAQECL HHAQDYGGLL LLATASGNAS MVNKLAEGAE 720 RDGKNNVAFM SYFLQGKLDA CLELLIRTGR LPEAAFLART YLPSQVSRVV KLWRENLSKV 780 NQKAAESLAD PTEYENLFPG LKEAFVVEEW VKETHADLWP AKQYPLVTPN EERNVMEEAK 840 RFQPSRATAQ QEPDGKPASS PVIMASQTTH KEEKSFQELE DDLDTMELED IDTTDINLDE 900 DILDD 906 |
| Keyword | KW-0007--Acetylation |
| Interpro | IPR006692--Coatomer_WD-assoc_reg |
| PROSITE | |
| Pfam | |
| Gene Ontology | GO:0030126--C:COPI vesicle coat |