| Tag |
Content |
| dbPAF ID |
dbPAF-0001143 |
| Uniprot Accession |
O35141; RASF5_RAT;
|
| Genbank Protein ID |
NP_062238.1;
|
| Genbank Nucleotide ID |
NM_019365.3;
|
| Protein Name |
Ras association domain-containing protein 5 |
| Protein Synonyms/Alias |
Maxp1;New ras effector 1; |
| Gene Name |
Rassf5 |
| Gene Synonyms/Alias |
Nore1; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis (By similarity).Functional Description
Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 177 | GPALDRQSPESTLTP | PhosphoSitePlus;UniProt;curated | 22135298; 22673903; 23984901 |
|
Sequence
(Fasta) | MASPAIGQRP YPLLLDPEPP RYLQSLGGTE PPPPARPRRC IPTALISASG ASEGRGSRRN 60
ARGDPEPTPR DCRHARPVRP GLQQRLRRRP GSHRPRDVRS IFEQPQDPRV LAERGEGHRF 120
AELALRGGPG WCDLCGREVL RQALRCANCK FTCHPECRSL IQLDCRQKEG PALDRQSPES 180
TLTPTFNKNV CKAVEETQHP PTIQEIKQKI DSYNSREKHC LGMKLSEDGT YTGFIKVHLK 240
LRRPVTVPAG IRPQSIYDAI KEVNPAATTD KRTSFYLPLD AIKQLHISSS TTVSEVIQGL 300
LKKFMVVDNP QKFALFKRIH KDGQVLFQKL SIADCPLYLR LLAGPDTDVL SFVLKENETG 360
DVEWDAFSIP ELQNFLTILE KEEQDKIHQL QKKYNKFRQK LEEALRESQG KPG
414Fasta Sequence
>O35141|Rassf5|Rattus norvegicus(Rat)
MASPAIGQRPYPLLLDPEPPRYLQSLGGTEPPPPARPRRCIPTALISASGASEGRGSRRNARGDPEPTPRDCRHARPVRPGLQQRLRRRPGSHRPRDVRSIFEQPQDPRVLAERGEGHRFAELALRGGPGWCDLCGREVLRQALRCANCKFTCHPECRSLIQLDCRQKEGPALDRQSPESTLTPTFNKNVCKAVEETQHPPTIQEIKQKIDSYNSREKHCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNPAATTDKRTSFYLPLDAIKQLHISSSTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADCPLYLRLLAGPDTDVLSFVLKENETGDVEWDAFSIPELQNFLTILEKEEQDKIHQLQKKYNKFRQKLEEALRESQGKPG
|
| Keyword |
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0479--Metal-binding
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0043--Tumor suppressor
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR002219--PE/DAG-bd
IPR000159--RA_dom
IPR011524--SARAH_dom
IPR029071--Ubiquitin-rel_dom
|
| PROSITE |
PS50200--RA
PS50951--SARAH
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
|
| Pfam |
PF00130--C1_1
PF16517--Nore1-SARAH
PF00788--RA
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0006915--P:apoptotic process
GO:0035556--P:intracellular signal transduction
GO:0008285--P:negative regulation of cell proliferation
GO:0031398--P:positive regulation of protein ubiquitination
GO:1900180--P:regulation of protein localization to nucleus
|
