| Tag |
Content |
| dbPAF ID |
dbPAF-0001136 |
| Uniprot Accession |
O35115; FHL2_RAT;
|
| Genbank Protein ID |
NP_113865.1; XP_006244911.1;
|
| Genbank Nucleotide ID |
NM_031677.1; XM_006244849.2;
|
| Protein Name |
Four and a half LIM domains protein 2 |
| Protein Synonyms/Alias |
|
| Gene Name |
Fhl2 |
| Gene Synonyms/Alias |
Dral;Slim3; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity).Functional Description
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MTERFDCHHC NESLYGKKYI LKEENPHCVA CFEELYANTC EECGTPIGCD CKDLSYKDRH 60
WHEGCFHCSR CGSSLVDKPF AAKEEQLLCT DCYSNEYSSK CQECKKTIMP GTRKMEYKGS 120
SWHETCFTCQ RCQQPIGTKS FIPKENQNFC VPCYEKQYAL QCVQCKKPIT TGGVTYRDQP 180
WHRECFVCTA CKKQLSGQRF TARDEFPYCL TCFCDLYAKK CAGCTNPISG LGGTKYISFE 240
ERQWHNDCFN CKKCSLSLVG RGFLTERDDI LCPDCGKDI
Fasta Sequence
>O35115|Fhl2|Rattus norvegicus(Rat)
MTERFDCHHCNESLYGKKYILKEENPHCVACFEELYANTCEECGTPIGCDCKDLSYKDRHWHEGCFHCSRCGSSLVDKPFAAKEEQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFTCQRCQQPIGTKSFIPKENQNFCVPCYEKQYALQCVQCKKPITTGGVTYRDQPWHRECFVCTACKKQLSGQRFTARDEFPYCLTCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI
|
| Keyword |
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0440--LIM domain
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR001781--Znf_LIM
|
| PROSITE |
PS00478--LIM_DOMAIN_1
PS50023--LIM_DOMAIN_2
|
| Pfam |
PF00412--LIM
|
| Gene Ontology |
GO:0015629--C:actin cytoskeleton
GO:0005925--C:focal adhesion
GO:0031430--C:M band
GO:0005654--C:nucleoplasm
GO:0030018--C:Z disc
GO:0008134--F:transcription factor binding
GO:0008270--F:zinc ion binding
GO:0055014--P:atrial cardiac muscle cell development
GO:0060347--P:heart trabecula formation
GO:0043066--P:negative regulation of apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001649--P:osteoblast differentiation
GO:0009725--P:response to hormone
GO:0006351--P:transcription, DNA-templated
GO:0055015--P:ventricular cardiac muscle cell development
|
