dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001135
Uniprot Accession O35112; CD166_RAT; O55172;
Genbank Protein ID NP_113941.1;
Genbank Nucleotide ID NM_031753.1;
Protein Name CD166 antigen
Protein Synonyms/Alias Activated leukocyte cell adhesion molecule;HB2;KG-CAM;Protein MEMD;SB-10 antigen;
Gene Name Alcam
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system. May be involved in osteogenesis. May play an important role in the development of a variety of mesenchymal tissues (By similarity).
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
38VNSAYGDTIVMPCRLcurated23800682
Sequence
(Fasta)
MASKGSPSCR LVFCLLISAA VLRPGLGWYT VNSAYGDTIV MPCRLDVPQN LMFGKWKYEK 60
PDGSPVFIAF RSSTKKSVQY DDVPEYKDRL SLSENYTLSI NNAKISDEKR FVCMLVTEDN 120
VFEAPTLVKV FKQPSKPEIV NRAAFLETEQ LKKLGDCISR DSYPDGNITW YRNGKVLQPV 180
DGEVSILFKK EIDPGTQLYT MTSSLEYKTT KSDIQMPFTC SVTYYGPSGQ KTIYSEQAIF 240
DIYYPTEQVT IQVLPPKNAI KEGDNITLQC LGNGNPPPEE FMFYLPGQAE GIRSSNTYTL 300
TDVRRNATGD YKCSLIDQRN MAASTTITVH YLDLSLNPSG EVTKQIGDTL PVSCTISASR 360
NATVVWMKDN IRLRSSPSFS SLHYQDAGNY VCETALQEVE GLKKRESLTL IVEGKPQIKM 420
TKKTDPSGLS KTIICHVEGF PKPAIQWTIT GSGSVINQTE ESPYINGRYY SKIIISPEEN 480
VTLTCTAENQ LERTVNSLNV SAISIPEHDE ADDISDENRE KVNDQAKLIV GIVVGLLLAA 540
LVAGVVYWLY MKKSKTASKH VNKDLGNMEE NKKLEENNHK TEA 584
Keyword

KW-0130--Cell adhesion
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0393--Immunoglobulin domain
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR013162--CD80_C2-set
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR003599--Ig_sub

PROSITE

PS50835--IG_LIKE

Pfam

PF08205--C2-set_2

Gene Ontology

GO:0030424--C:axon
GO:0009897--C:external side of plasma membrane
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0016021--C:integral component of membrane
GO:0043025--C:neuronal cell body
GO:0007155--P:cell adhesion
GO:0008045--P:motor neuron axon guidance