dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001130
Uniprot Accession O35094; TIM44_RAT;
Genbank Protein ID NP_058963.1;
Genbank Nucleotide ID NM_017267.1;
Protein Name Mitochondrial import inner membrane translocase subunit TIM44
Protein Synonyms/Alias
Gene Name Timm44
Gene Synonyms/Alias Mimt44;Tim44;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
51GELTLTKSYSSGSRKdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
52ELTLTKSYSSGSRKGdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
53LTLTKSYSSGSRKGFdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
54TLTKSYSSGSRKGFLdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
56TKSYSSGSRKGFLSGdbPTM 3.0;PhosphoSitePlus;curated16641100; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MAAAALRGGW CRCPRRCLGS GIQFLSSHNL PRGGSSYQIS RPGGELTLTK SYSSGSRKGF 60
LSGLLDNIKQ ELAQNKEMKE SIKKFRDEAK KLEESDALQE ARRKYKTIES ETVRTSEAIK 120
KKLGELTGTV KESLDEVSKS DLGRKIKEGV EEAARTAKQS AESVSKGGEK LGKTAAFKAI 180
SQGVESVKKE IDESVLGHTG TYRRPERLRK RTEFAGAKFK ESKVFEANEE ALGVVLHKDS 240
KWYQQWKDFK DNNVVFNRFF EMKMKYDESD NVLIRASRAL TDKVTDLLGG LFSKTEMSEV 300
LTEILRVDPT FDKDRFLHQC ETDIIPNILE AMISGELDIL KDWCYEATYN QLAHSIQQAK 360
ALGLQFHSRI LDISNVDLAM GKMMEQGPVL IVTFQAQLVM VIKNPKGEVF DGDPDKVLRM 420
LYVWALCRDQ EELNPYAAWR LLDISASSTE QIL 454
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0999--Mitochondrion inner membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0811--Translocation
KW-0813--Transport
Interpro

IPR017303--Tim44
IPR007379--Tim44-like_dom
PROSITE
Pfam

PF04280--Tim44
Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005524--F:ATP binding
GO:0051087--F:chaperone binding
GO:0015450--F:P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO:0006886--P:intracellular protein transport
GO:0030150--P:protein import into mitochondrial matrix