| Tag |
Content |
| dbPAF ID |
dbPAF-0001129 |
| Uniprot Accession |
O35085; ARX_MOUSE; A2A4G9; Q9QYT4;
|
| Genbank Protein ID |
NP_001292869.1; NP_031518.2;
|
| Genbank Nucleotide ID |
NM_001305940.1; NM_007492.4;
|
| Protein Name |
Homeobox protein ARX |
| Protein Synonyms/Alias |
Aristaless-related homeobox; |
| Gene Name |
Arx |
| Gene Synonyms/Alias |
|
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (By similarity).Functional Description
Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MSNQYQEEGC SERPECKSKS PTLLSSYCID SILGRRSPCK MRLLGAAQSL PAPLASRADQ 60
EKAMQGSPKS SSAPFEAELH LPPKLRRLYG PGGGRLLQGA AAAAAAAAAA AAAATATGTA 120
GPRGEVPPPP PPAARPGERQ DSAGAVAAAA AAAAWDTLKI SQAPQVSISR SKSYRENGAP 180
FVPPPPALDE LSGPGGVAHP EERLSAASGP GSAPAAGGGT GAEDDEEELL EDEEDEEEEE 240
ELLEDDDEEL LEDDARALLK EPRRCSVATT GTVAAAAAAA AAAVATEGGE LSPKEELLLH 300
PEDAEGKDGE DSVCLSAGSD SEEGLLKRKQ RRYRTTFTSY QLEELERAFQ KTHYPDVFTR 360
EELAMRLDLT EARVQVWFQN RRAKWRKREK AGAQTHPPGL PFPGPLSATH PLSPYLDASP 420
FPPHHPALDS AWTAAAAAAA AAFPSLPPPP GSASLPPSGA PLGLSTFLGA AVFRHPAFIS 480
PAFGRLFSTM APLTSASTAA ALLRQPTPAV EGAVASGALA DPATAAADRR ASSIAALRLK 540
AKEHAAQLTQ LNILPGTSTG KEVC
565Fasta Sequence
>O35085|Arx|Mus musculus(Mouse)
MSNQYQEEGCSERPECKSKSPTLLSSYCIDSILGRRSPCKMRLLGAAQSLPAPLASRADQEKAMQGSPKSSSAPFEAELHLPPKLRRLYGPGGGRLLQGAAAAAAAAAAAAAAATATGTAGPRGEVPPPPPPAARPGERQDSAGAVAAAAAAAAWDTLKISQAPQVSISRSKSYRENGAPFVPPPPALDELSGPGGVAHPEERLSAASGPGSAPAAGGGTGAEDDEEELLEDEEDEEEEEELLEDDDEELLEDDARALLKEPRRCSVATTGTVAAAAAAAAAAVATEGGELSPKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGAQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAFPSLPPPPGSASLPPSGAPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAPLTSASTAAALLRQPTPAVEGAVASGALADPATAAADRRASSIAALRLKAKEHAAQLTQLNILPGTSTGKEVC
|
| Keyword |
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR017970--Homeobox_CS
IPR001356--Homeobox_dom
IPR009057--Homeodomain-like
IPR003654--OAR_dom
|
| PROSITE |
PS00027--HOMEOBOX_1
PS50071--HOMEOBOX_2
PS50803--OAR
|
| Pfam |
PF00046--Homeobox
PF03826--OAR
|
| Gene Ontology |
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001206--F:transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0007411--P:axon guidance
GO:0021846--P:cell proliferation in forebrain
GO:0021853--P:cerebral cortex GABAergic interneuron migration
GO:0021800--P:cerebral cortex tangential migration
GO:0021831--P:embryonic olfactory bulb interneuron precursor migration
GO:0072148--P:epithelial cell fate commitment
GO:0030900--P:forebrain development
GO:0021759--P:globus pallidus development
GO:0044241--P:lipid digestion
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001764--P:neuron migration
GO:0021772--P:olfactory bulb development
GO:0010628--P:positive regulation of gene expression
GO:0046622--P:positive regulation of organ growth
GO:0042127--P:regulation of cell proliferation
GO:0006351--P:transcription, DNA-templated
|
