Tag |
Content |
dbPAF ID |
dbPAF-0001128 |
Uniprot Accession |
O35084; CP27B_MOUSE;
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Genbank Protein ID |
NP_034139.2;
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Genbank Nucleotide ID |
NM_010009.2;
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Protein Name |
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
Protein Synonyms/Alias |
25-OHD-1 alpha-hydroxylase;25-hydroxyvitamin D(3) 1-alpha-hydroxylase;VD3 1A hydroxylase;Calcidiol 1-monooxygenase;Cytochrome P450 subfamily XXVIIB polypeptide 1;Cytochrome P450C1 alpha;Cytochrome P450VD1-alpha;Cytochrome p450 27B1; |
Gene Name |
Cyp27b1 |
Gene Synonyms/Alias |
Cyp27b;Cyp40; |
Organism |
Mus musculus(Mouse) |
NCBI Taxa ID |
10090 |
Functional Description (View all) |
Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.Functional Description
Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.
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Phosphorylation Sites
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dbPAF PTMs: 1 Position | Peptides | Source | References ( PMIDs ) |
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294 | MPSGHHLTHFLFREK | PhosphoSitePlus | 22135298 |
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Sequence (Fasta) | MTQAVKLASR VFHRIHLPLQ LDASLGSRGS ESVLRSLSDI PGPSTLSFLA ELFCKGGLSR 60 LHELQVHGAA RYGPIWSGSF GTLRTVYVAD PTLVEQLLRQ ESHCPERCSF SSWAEHRRRH 120 QRACGLLTAD GEEWQRLRSL LAPLLLRPQA AAGYAGTLDN VVRDLVRRLR RQRGRGSGLP 180 GLVLDVAGEF YKFGLESIGA VLLGSRLGCL EAEVPPDTET FIHAVGSVFV STLLTMAMPN 240 WLHHLIPGPW ARLCRDWDQM FAFAQRHVEL REGEAAMRNQ GKPEEDMPSG HHLTHFLFRE 300 KVSVQSIVGN VTELLLAGVD TVSNTLSWTL YELSRHPDVQ TALHSEITAG TRGSCAHPHG 360 TALSQLPLLK AVIKEVLRLY PVVPGNSRVP DRDIRVGNYV IPQDTLVSLC HYATSRDPTQ 420 FPDPNSFNPA RWLGEGPTPH PFASLPFGFG KRSCIGRRLA ELELQMALSQ ILTHFEVLPE 480 PGALPIKPMT RTVLVPERSI NLQFVDR
508Fasta Sequence
>O35084|Cyp27b1|Mus musculus(Mouse) MTQAVKLASRVFHRIHLPLQLDASLGSRGSESVLRSLSDIPGPSTLSFLAELFCKGGLSRLHELQVHGAARYGPIWSGSFGTLRTVYVADPTLVEQLLRQESHCPERCSFSSWAEHRRRHQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDNVVRDLVRRLRRQRGRGSGLPGLVLDVAGEFYKFGLESIGAVLLGSRLGCLEAEVPPDTETFIHAVGSVFVSTLLTMAMPNWLHHLIPGPWARLCRDWDQMFAFAQRHVELREGEAAMRNQGKPEEDMPSGHHLTHFLFREKVSVQSIVGNVTELLLAGVDTVSNTLSWTLYELSRHPDVQTALHSEITAGTRGSCAHPHGTALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLCHYATSRDPTQFPDPNSFNPARWLGEGPTPHPFASLPFGFGKRSCIGRRLAELELQMALSQILTHFEVLPEPGALPIKPMTRTVLVPERSINLQFVDR
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Keyword |
KW-0181--Complete proteome KW-0349--Heme KW-0408--Iron KW-0472--Membrane KW-0479--Metal-binding KW-0496--Mitochondrion KW-0503--Monooxygenase KW-0521--NADP KW-0560--Oxidoreductase KW-1185--Reference proteome KW-0809--Transit peptide
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Interpro |
IPR001128--Cyt_P450 IPR017972--Cyt_P450_CS IPR002401--Cyt_P450_E_grp-I
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PROSITE |
PS00086--CYTOCHROME_P450
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Pfam |
PF00067--p450
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Gene Ontology |
GO:0005737--C:cytoplasm GO:0031966--C:mitochondrial membrane GO:0005739--C:mitochondrion GO:0004498--F:calcidiol 1-monooxygenase activity GO:0020037--F:heme binding GO:0005506--F:iron ion binding GO:0030282--P:bone mineralization GO:0036378--P:calcitriol biosynthetic process from calciol GO:0055074--P:calcium ion homeostasis GO:0006816--P:calcium ion transport GO:0046697--P:decidualization GO:0070314--P:G1 to G0 transition GO:0010956--P:negative regulation of calcidiol 1-monooxygenase activity GO:0030308--P:negative regulation of cell growth GO:0008285--P:negative regulation of cell proliferation GO:0045618--P:positive regulation of keratinocyte differentiation GO:0010980--P:positive regulation of vitamin D 24-hydroxylase activity GO:0070564--P:positive regulation of vitamin D receptor signaling pathway GO:0030500--P:regulation of bone mineralization GO:0043627--P:response to estrogen GO:0034341--P:response to interferon-gamma GO:0032496--P:response to lipopolysaccharide GO:0033280--P:response to vitamin D GO:0042369--P:vitamin D catabolic process GO:0042359--P:vitamin D metabolic process
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