dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001128
Uniprot Accession O35084; CP27B_MOUSE;
Genbank Protein ID NP_034139.2;
Genbank Nucleotide ID NM_010009.2;
Protein Name 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Protein Synonyms/Alias 25-OHD-1 alpha-hydroxylase;25-hydroxyvitamin D(3) 1-alpha-hydroxylase;VD3 1A hydroxylase;Calcidiol 1-monooxygenase;Cytochrome P450 subfamily XXVIIB polypeptide 1;Cytochrome P450C1 alpha;Cytochrome P450VD1-alpha;Cytochrome p450 27B1;
Gene Name Cyp27b1
Gene Synonyms/Alias Cyp27b;Cyp40;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.
Phosphorylation Sites
dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
294MPSGHHLTHFLFREKPhosphoSitePlus22135298
Sequence
(Fasta)
MTQAVKLASR VFHRIHLPLQ LDASLGSRGS ESVLRSLSDI PGPSTLSFLA ELFCKGGLSR 60
LHELQVHGAA RYGPIWSGSF GTLRTVYVAD PTLVEQLLRQ ESHCPERCSF SSWAEHRRRH 120
QRACGLLTAD GEEWQRLRSL LAPLLLRPQA AAGYAGTLDN VVRDLVRRLR RQRGRGSGLP 180
GLVLDVAGEF YKFGLESIGA VLLGSRLGCL EAEVPPDTET FIHAVGSVFV STLLTMAMPN 240
WLHHLIPGPW ARLCRDWDQM FAFAQRHVEL REGEAAMRNQ GKPEEDMPSG HHLTHFLFRE 300
KVSVQSIVGN VTELLLAGVD TVSNTLSWTL YELSRHPDVQ TALHSEITAG TRGSCAHPHG 360
TALSQLPLLK AVIKEVLRLY PVVPGNSRVP DRDIRVGNYV IPQDTLVSLC HYATSRDPTQ 420
FPDPNSFNPA RWLGEGPTPH PFASLPFGFG KRSCIGRRLA ELELQMALSQ ILTHFEVLPE 480
PGALPIKPMT RTVLVPERSI NLQFVDR 508
Keyword

KW-0181--Complete proteome
KW-0349--Heme
KW-0408--Iron
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0503--Monooxygenase
KW-0521--NADP
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0809--Transit peptide

Interpro

IPR001128--Cyt_P450
IPR017972--Cyt_P450_CS
IPR002401--Cyt_P450_E_grp-I

PROSITE

PS00086--CYTOCHROME_P450

Pfam

PF00067--p450

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031966--C:mitochondrial membrane
GO:0005739--C:mitochondrion
GO:0004498--F:calcidiol 1-monooxygenase activity
GO:0020037--F:heme binding
GO:0005506--F:iron ion binding
GO:0030282--P:bone mineralization
GO:0036378--P:calcitriol biosynthetic process from calciol
GO:0055074--P:calcium ion homeostasis
GO:0006816--P:calcium ion transport
GO:0046697--P:decidualization
GO:0070314--P:G1 to G0 transition
GO:0010956--P:negative regulation of calcidiol 1-monooxygenase activity
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0045618--P:positive regulation of keratinocyte differentiation
GO:0010980--P:positive regulation of vitamin D 24-hydroxylase activity
GO:0070564--P:positive regulation of vitamin D receptor signaling pathway
GO:0030500--P:regulation of bone mineralization
GO:0043627--P:response to estrogen
GO:0034341--P:response to interferon-gamma
GO:0032496--P:response to lipopolysaccharide
GO:0033280--P:response to vitamin D
GO:0042369--P:vitamin D catabolic process
GO:0042359--P:vitamin D metabolic process