| Tag |
Content |
| dbPAF ID |
dbPAF-0001124 |
| Uniprot Accession |
O35074; PTGIS_MOUSE;
|
| Genbank Protein ID |
NP_032994.1;
|
| Genbank Nucleotide ID |
NM_008968.3;
|
| Protein Name |
Prostacyclin synthase |
| Protein Synonyms/Alias |
Prostaglandin I2 synthase; |
| Gene Name |
Ptgis |
| Gene Synonyms/Alias |
Cyp8; |
| Organism |
Mus musculus(Mouse) |
| NCBI Taxa ID |
10090 |
Functional Description
(View all) |
Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).Functional Description
Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MSWAALLGLL AVLLLLLLLL SRRRARRPGE PPLDLGSIPW LGHALEFGRD AASFLTRMKE 60
KHGDIFTVLV GGRYVTVLLD PHSYDTVVWE LRTRLDFHPY AIFLMERIFD LQLPNFNPSE 120
EKARMKPTLM HRDLQALTEA MYTNLRTVLL GDSTEAGSGW QETGLLEFSY NALLSAGYLT 180
LYGVEASPRT HESQAQDRVH SADVFHTFRQ LDLLLPKLAR GSLSAGDKDH ACSVKNRLWK 240
LLSPARLASR ADRSSWLESY LRHLEEMGVS EEMQARALVL QLWATQGNMG PTAFWLLLFL 300
LKNPEALAAV RAELKHTVWQ AEQPVSQMTT LPQKILDSMP VLDSVLNETL RLTAAPFITR 360
EVMADLALPM ADGREFSLRR GDRLLLFPFL SPQKDPEIYT EPEVFKYNRF LNPDGSEKKD 420
FYKDGKRLKN YNMPWGAGHN QCLGKSYAIN SIKQFVVLLL THFDLELGSE DTEVPEFDLS 480
RYGFGLMQPE EDVPIRYRAR L
502Fasta Sequence
>O35074|Ptgis|Mus musculus(Mouse)
MSWAALLGLLAVLLLLLLLLSRRRARRPGEPPLDLGSIPWLGHALEFGRDAASFLTRMKEKHGDIFTVLVGGRYVTVLLDPHSYDTVVWELRTRLDFHPYAIFLMERIFDLQLPNFNPSEEKARMKPTLMHRDLQALTEAMYTNLRTVLLGDSTEAGSGWQETGLLEFSYNALLSAGYLTLYGVEASPRTHESQAQDRVHSADVFHTFRQLDLLLPKLARGSLSAGDKDHACSVKNRLWKLLSPARLASRADRSSWLESYLRHLEEMGVSEEMQARALVLQLWATQGNMGPTAFWLLLFLLKNPEALAAVRAELKHTVWQAEQPVSQMTTLPQKILDSMPVLDSVLNETLRLTAAPFITREVMADLALPMADGREFSLRRGDRLLLFPFLSPQKDPEIYTEPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNQCLGKSYAINSIKQFVVLLLTHFDLELGSEDTEVPEFDLSRYGFGLMQPEEDVPIRYRARL
|
| Keyword |
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0349--Heme
KW-0408--Iron
KW-0413--Isomerase
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0479--Metal-binding
KW-0643--Prostaglandin biosynthesis
KW-0644--Prostaglandin metabolism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR001128--Cyt_P450
IPR024204--Cyt_P450_CYP7A1-type
IPR002403--Cyt_P450_E_grp-IV
IPR027286--PTGIS
|
| PROSITE |
|
| Pfam |
PF00067--p450
|
| Gene Ontology |
GO:0005901--C:caveola
GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0005615--C:extracellular space
GO:0016021--C:integral component of membrane
GO:0005634--C:nucleus
GO:0020037--F:heme binding
GO:0005506--F:iron ion binding
GO:0004497--F:monooxygenase activity
GO:0016705--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0008116--F:prostaglandin-I synthase activity
GO:0097190--P:apoptotic signaling pathway
GO:0071456--P:cellular response to hypoxia
GO:0071347--P:cellular response to interleukin-1
GO:0071354--P:cellular response to interleukin-6
GO:0046697--P:decidualization
GO:0007566--P:embryo implantation
GO:0050728--P:negative regulation of inflammatory response
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045019--P:negative regulation of nitric oxide biosynthetic process
GO:0045766--P:positive regulation of angiogenesis
GO:1900119--P:positive regulation of execution phase of apoptosis
GO:0035360--P:positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0001516--P:prostaglandin biosynthetic process
GO:0042981--P:regulation of apoptotic process
|
