dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001121
Uniprot Accession O35054; CLD4_MOUSE;
Genbank Protein ID NP_034033.1;
Genbank Nucleotide ID NM_009903.2;
Protein Name Claudin-4
Protein Synonyms/Alias Clostridium perfringens enterotoxin receptor;CPE-R;CPE-receptor;
Gene Name Cldn4
Gene Synonyms/Alias Cper;Cpetr1;
Organism Mus musculus(Mouse)
NCBI Taxa ID 10090
Functional Description
(View all)
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Phosphorylation Sites
dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
195RSNDKPYSAKYSAARdbPTM 3.0;PhosphoSitePlus;curated18786529; 16381945; 23193290; 22135298; 22817900
199KPYSAKYSAARSVPAPhosphoSitePlus22135298
209RSVPASNYV------PhosphoSitePlus22135298
Sequence
(Fasta)
MASMGLQVLG ISLAVLGWLG IILSCALPMW RVTAFIGSNI VTAQTSWEGL WMNCVVQSTG 60
QMQCKMYDSM LALPQDLQAA RALMVISIIV GALGMLLSVV GGKCTNCMED ETVKAKIMIT 120
AGAVFIVASM LIMVPVSWTA HNVIRDFYNP MVASGQKREM GASLYVGWAA SGLLLLGGGL 180
LCCSCPPRSN DKPYSAKYSA ARSVPASNYV 211
Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0796--Tight junction
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR006187--Claudin
IPR003550--Claudin4
IPR017974--Claudin_CS
IPR004031--PMP22/EMP/MP20/Claudin

PROSITE

PS01346--CLAUDIN

Pfam

PF00822--PMP22_Claudin

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0016327--C:apicolateral plasma membrane
GO:0009925--C:basal plasma membrane
GO:0005923--C:bicellular tight junction
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0016328--C:lateral plasma membrane
GO:0005886--C:plasma membrane
GO:0042802--F:identical protein binding
GO:0005198--F:structural molecule activity
GO:0016338--P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
GO:0007623--P:circadian rhythm
GO:0061436--P:establishment of skin barrier
GO:0007565--P:female pregnancy
GO:0032570--P:response to progesterone