dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001119
Uniprot Accession O35049; NSMA2_RAT;
Genbank Protein ID NP_446057.1;
Genbank Nucleotide ID NM_053605.1;
Protein Name Sphingomyelin phosphodiesterase 3
Protein Synonyms/Alias Confluent 3Y1 cell-associated protein 1;Neutral sphingomyelinase 2;nSMase-2;nSMase2;Neutral sphingomyelinase II;
Gene Name Smpd3
Gene Synonyms/Alias Cca1;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. Overexpression enhances cell death, suggesting that it may be involved in apoptosis control. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions.
Phosphorylation Sites
 dbPAF PTMs: 21 (View all)
PositionPeptidesSourceReferences ( PMIDs )
170ARPQIKIYIDSPTNTcurated23712012; 21630457
173QIKIYIDSPTNTSIScurated23712012; 21630457
175KIYIDSPTNTSISAAcurated23712012; 21630457
177YIDSPTNTSISAASFcurated23712012; 21630457
178IDSPTNTSISAASFScurated23712012; 21630457
180SPTNTSISAASFSSLcurated23712012; 21630457
183NTSISAASFSSLVSPcurated23712012
202GARAVPGSIKRTASVPhosphoSitePlus;curated22135298; 23712012; 21630457
206VPGSIKRTASVEYKGcurated21630457
208GSIKRTASVEYKGDGPhosphoSitePlus;curated22135298; 23712012; 21630457
211KRTASVEYKGDGGRHcurated23712012; 21630457
220GDGGRHPSDEAANGPcurated23712012; 21630457
229EAANGPASGEQADGScurated23712012; 21630457
236SGEQADGSLEDSCIVPhosphoSitePlus;curated22135298; 23712012; 21630457
287HNQRDGDSGSLGSPScurated23712012; 21630457
289QRDGDSGSLGSPSASPhosphoSitePlus;UniProt;curated22135298; 22673903; 23712012; 21630457
292GDSGSLGSPSASRESPhosphoSitePlus;curated22135298; 23712012; 21630457
294SGSLGSPSASRESLVPhosphoSitePlus;curated22135298; 23712012; 21630457
296SLGSPSASRESLVKAcurated23712012; 21630457
299SPSASRESLVKARAGcurated23712012; 21630457
Sequence
(Fasta)		MVLYTTPFPN SCLSALHAVS WALIFPCYWL VDRLVASFIP TTYEKRQRAD DPCYLQLFCT 60
VLFTPVYLAL LVAALPFAFL GFIFWSPLQS ARRPYSYSRL EDKSPAGGAA LLSEWKGTGA 120
GKSFCFATAN VCLLPDSLAR LNNVFNTQAR AKEIGQRIRN GAARPQIKIY IDSPTNTSIS 180
AASFSSLVSP QGSDGARAVP GSIKRTASVE YKGDGGRHPS DEAANGPASG EQADGSLEDS 240
CIVRIGGEEG GRAQEADDPA PGSQARNGAG GTPKGQTPNH NQRDGDSGSL GSPSASRESL 300
VKARAGQDSG GSGEPGSNSK LLYKTSVVKK AAARRRRHPD EAFDHEVSAF FPANLDFLCL 360
QEVFDKRAAA KLKEQLHGYF EYILYDVGVY GCHGCCNFKC LNSGLFFASR YPVMDVAYHC 420
YPNGCSFDAL ASKGALFLKV QVGSTPQDQR IVGYIACTHL HAPPEDSAIR CEQLDLLQDW 480
LADFRKSTSS TSTANPEELV VFDVICGDLN FDNCSSDDKL EQQHSLFTRY KDPCRLGPGE 540
EKPWAIGTLL DINGLYDEDV CTPDNLQKVL ESEEGRREYL AFPTSKSPGA GQKGRKDLLK 600
GNGRRIDYML HAEEGLCPDW KAEVEEFSFI TQLSGLTDHL PVAMRLMVSA GEEEA 656
Keyword

KW-0131--Cell cycle
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0443--Lipid metabolism
KW-0449--Lipoprotein
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0746--Sphingolipid metabolism
Interpro

IPR005135--Endo/exonuclease/phosphatase
PROSITE
Pfam

PF03372--Exo_endo_phos
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000139--C:Golgi membrane
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0004767--F:sphingomyelin phosphodiesterase activity
GO:0007568--P:aging
GO:0014824--P:artery smooth muscle contraction
GO:0007049--P:cell cycle
GO:0071347--P:cellular response to interleukin-1
GO:0090494--P:dopamine uptake
GO:0007275--P:multicellular organismal development
GO:0051481--P:negative regulation of cytosolic calcium ion concentration
GO:2000304--P:positive regulation of ceramide biosynthetic process
GO:1903543--P:positive regulation of exosomal secretion
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045429--P:positive regulation of nitric oxide biosynthetic process
GO:0006665--P:sphingolipid metabolic process