dbPAF Protein Information
| Tag | Content | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dbPAF ID | dbPAF-0001118 | ||||||||
| Uniprot Accession | O35048; 3BHS7_RAT; | ||||||||
| Genbank Protein ID | NP_647545.1; | ||||||||
| Genbank Nucleotide ID | NM_139329.1; | ||||||||
| Protein Name | 3 beta-hydroxysteroid dehydrogenase type 7 | ||||||||
| Protein Synonyms/Alias | 3 beta-hydroxysteroid dehydrogenase type VII;3-beta-HSD VII;3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase;C(27) 3-beta-HSD; | ||||||||
| Gene Name | Hsd3b7 | ||||||||
| Gene Synonyms/Alias | Cca2; | ||||||||
| Organism | Rattus norvegicus(Rat) | ||||||||
| NCBI Taxa ID | 10116 | ||||||||
| Functional Description (View all) |
The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (By similarity). | ||||||||
| Phosphorylation Sites |
dbPAF PTMs: 1
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| Sequence (Fasta) | MADSAQVPAL VYLVTGGCGF LGEHIVRMLL EWEPRLRELR VFDLHLSSWL EELKTGPVQV 60 TAIQGDVTQA HEVAAAMAGS HVVIHTAGLV DVFGKASPET IHKVNVQGTQ NVIDACVQTG 120 TRLLVYTSSM EVVGPNVKGH PFYRGNEDTP YEAIHRHPYP CSKALAEQLV LEANGRKGLR 180 FGGRLFRAIP ASVEHGRVYV GNVAWMHILV ARELEQRAAL MGGQVYFCYD KSPYKSYEDF 240 NMEFLSPCGL RLIGTHPLLP YWLLVLLTAL NALLQWLLRP LVLYTPLLNP YTLAVANTTF 300 TVSTNKAQRH FGYKPLFSWE ESRARTIHWV QAMEGSAW 339 |
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| Keyword | KW-0181--Complete proteome |
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| Interpro | IPR002225--3Beta_OHSteriod_DH/Estase |
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| PROSITE | |||||||||
| Pfam | PF01073--3Beta_HSD |
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| Gene Ontology | GO:0005789--C:endoplasmic reticulum membrane |